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2013 1
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Page 1
Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis.
Rudman-Melnick V, Adam M, Stowers K, Potter A, Ma Q, Chokshi SM, Vanhoutte D, Valiente-Alandi I, Lindquist DM, Nieman ML, Kofron JM, Chung E, Park JS, Potter SS, Devarajan P. Rudman-Melnick V, et al. Sci Rep. 2024 Jan 3;14(1):439. doi: 10.1038/s41598-023-50195-0. Sci Rep. 2024. PMID: 38172172 Free PMC article.
Moreover, we identified that both models exhibited robust and previously unrecognized distal spatial pattern of TEC injury, outlined by persistent elevation of renal TEC injury markers including Krt8 and Vcam1, while the surviving proximal tubules (PTs) showed restored transcript …
Moreover, we identified that both models exhibited robust and previously unrecognized distal spatial pattern of TEC injury, outlined by pers …
Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis.
Rudman-Melnick V, Adam M, Stowers K, Potter A, Ma Q, Chokshi SM, Vanhoutte D, Valiente-Alandi I, Lindquist DM, Nieman ML, Kofron JM, Potter SS, Devarajan P. Rudman-Melnick V, et al. Res Sq [Preprint]. 2023 May 17:rs.3.rs-2880248. doi: 10.21203/rs.3.rs-2880248/v1. Res Sq. 2023. PMID: 37293022 Free PMC article. Updated. Preprint.
Moreover, we identified that both models exhibited robust and previously unrecognized distal spatial pattern of TEC injury, outlined by persistent elevation of renal TEC injury markers including Krt8, while the surviving proximal tubules (PTs) showed restored transcriptional sign …
Moreover, we identified that both models exhibited robust and previously unrecognized distal spatial pattern of TEC injury, outlined by pers …
Stability of novel urinary biomarkers used for lupus nephritis.
Cody EM, Rose JE, Huang B, Qiu T, Brunner HI, Devarajan P. Cody EM, et al. Front Pediatr. 2022 Jul 29;10:974049. doi: 10.3389/fped.2022.974049. eCollection 2022. Front Pediatr. 2022. PMID: 35967565 Free PMC article.
METHODS: Urine samples were tested by ELISA under shipping conditions, freeze/thaw, ambient and longer-term storage. Statistical analysis was performed via Deming Regression, Bland-Altman and Spearman Correlation Coefficient. ...Neither shipping on dry or wet ice exposure …
METHODS: Urine samples were tested by ELISA under shipping conditions, freeze/thaw, ambient and longer-term storage. Statistical anal …
Acute Kidney Injury and Risk of CKD and Hypertension after Pediatric Cardiac Surgery.
Zappitelli M, Parikh CR, Kaufman JS, Go AS, Kimmel PL, Hsu CY, Coca SG, Chinchilli VM, Greenberg JH, Moxey-Mims MM, Ikizler TA, Cockovski V, Dyer AM, Devarajan P; ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Investigators. Zappitelli M, et al. Clin J Am Soc Nephrol. 2020 Oct 7;15(10):1403-1412. doi: 10.2215/CJN.00150120. Epub 2020 Sep 18. Clin J Am Soc Nephrol. 2020. PMID: 32948644 Free PMC article.
BACKGROUND AND OBJECTIVES: The association of AKI after pediatric cardiac surgery with long-term CKD and hypertension development is unclear. The study objectives were to determine whether AKI after pediatric cardiac surgery is associated with incident CKD and hypertension …
BACKGROUND AND OBJECTIVES: The association of AKI after pediatric cardiac surgery with long-term CKD and hypertension development is …
Weight as a Risk Factor for Mortality in Critically Ill Patients.
Ayalon I, Woo JG, Basu RK, Kaddourah A, Goldstein SL, Kaplan JM; AWARE Investigators. Ayalon I, et al. Pediatrics. 2020 Aug;146(2):e20192829. doi: 10.1542/peds.2019-2829. Epub 2020 Jul 3. Pediatrics. 2020. PMID: 32620676 Free PMC article.
CONCLUSIONS: Patients who are underweight make up a significant proportion of all patients in the PICU, have a higher short-term mortality rate, and have a more complicated ICU course....
CONCLUSIONS: Patients who are underweight make up a significant proportion of all patients in the PICU, have a higher short-term mort …
Baby NINJA (Nephrotoxic Injury Negated by Just-in-Time Action): Reduction of Nephrotoxic Medication-Associated Acute Kidney Injury in the Neonatal Intensive Care Unit.
Stoops C, Stone S, Evans E, Dill L, Henderson T, Griffin R, Goldstein SL, Coghill C, Askenazi DJ. Stoops C, et al. J Pediatr. 2019 Dec;215:223-228.e6. doi: 10.1016/j.jpeds.2019.08.046. J Pediatr. 2019. PMID: 31761141 Free PMC article.
CONCLUSION(S): A systematic surveillance program to identify high-risk infants can prevent nephrotoxic-induced AKI and has the potential to prevent short and long-term consequences of AKI in critically ill infants....
CONCLUSION(S): A systematic surveillance program to identify high-risk infants can prevent nephrotoxic-induced AKI and has the potential to …
Association of Serum Uromodulin With ESKD and Kidney Function Decline in the Elderly: The Cardiovascular Health Study.
Steubl D, Buzkova P, Garimella PS, Ix JH, Devarajan P, Bennett MR, Chaves PHM, Shlipak MG, Bansal N, Sarnak MJ. Steubl D, et al. Am J Kidney Dis. 2019 Oct;74(4):501-509. doi: 10.1053/j.ajkd.2019.02.024. Epub 2019 May 22. Am J Kidney Dis. 2019. PMID: 31128770 Free PMC article.
However, little is known about the association of sUMOD levels with long-term kidney outcomes in older adults, a population with a high prevalence of interstitial fibrosis and tubular atrophy. ...
However, little is known about the association of sUMOD levels with long-term kidney outcomes in older adults, a population with a hi …
Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure.
Valiente-Alandi I, Potter SJ, Salvador AM, Schafer AE, Schips T, Carrillo-Salinas F, Gibson AM, Nieman ML, Perkins C, Sargent MA, Huo J, Lorenz JN, DeFalco T, Molkentin JD, Alcaide P, Blaxall BC. Valiente-Alandi I, et al. Circulation. 2018 Sep 18;138(12):1236-1252. doi: 10.1161/CIRCULATIONAHA.118.034609. Circulation. 2018. PMID: 29653926 Free PMC article.
Mice were analyzed 7 days after I/R to assess MF markers and inflammatory cell infiltration or 4 weeks after I/R to evaluate long-term effects of FN inhibition on cardiac function and fibrosis. Furthermore, inducible, fibroblast-restricted, FN gene-ablated (Tcf21(MerCreMer …
Mice were analyzed 7 days after I/R to assess MF markers and inflammatory cell infiltration or 4 weeks after I/R to evaluate long-term …
Kidney injury biomarkers 5 years after AKI due to pediatric cardiac surgery.
Greenberg JH, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Parikh CR, Zappitelli M; TRIBE-AKI Consortium. Greenberg JH, et al. Pediatr Nephrol. 2018 Jun;33(6):1069-1077. doi: 10.1007/s00467-018-3888-4. Epub 2018 Mar 6. Pediatr Nephrol. 2018. PMID: 29511889 Free PMC article.
BACKGROUND: We previously reported that children undergoing cardiac surgery are at high risk for long-term chronic kidney disease (CKD) and hypertension, although postoperative acute kidney injury (AKI) is not a risk factor for worse long-term kidney outcomes. We re …
BACKGROUND: We previously reported that children undergoing cardiac surgery are at high risk for long-term chronic kidney disease (CK …
Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study.
McMahon KR, Rod Rassekh S, Schultz KR, Pinsk M, Blydt-Hansen T, Mammen C, Tsuyuki RT, Devarajan P, Cuvelier GD, Mitchell LG, Baruchel S, Palijan A, Carleton BC, Ross CJ, Zappitelli M; Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Group. McMahon KR, et al. Can J Kidney Health Dis. 2017 Feb 16;4:2054358117690338. doi: 10.1177/2054358117690338. eCollection 2017. Can J Kidney Health Dis. 2017. PMID: 28270931 Free PMC article.
BACKGROUND: Childhood cancer survivors experience adverse drug events leading to lifelong health issues. The Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) team was established to validate and apply biomarkers of cancer tr …
BACKGROUND: Childhood cancer survivors experience adverse drug events leading to lifelong health issues. The Applying Biomarkers to Minimize …
21 results