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AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.
Mays LE, Wang L, Lin J, Bell P, Crawford A, Wherry EJ, Wilson JM. Mays LE, et al. Mol Ther. 2014 Jan;22(1):28-41. doi: 10.1038/mt.2013.134. Epub 2013 Jun 19. Mol Ther. 2014. PMID: 23778424 Free PMC article.
Following gene transfer of adeno-associated virus 2/8 (AAV2/8) to the muscle, C57BL/6 mice show long-term expression of a nuclear-targeted LacZ (nLacZ) transgene with minimal immune activation. ...
Following gene transfer of adeno-associated virus 2/8 (AAV2/8) to the muscle, C57BL/6 mice show long-term expression of a nuclear-tar …
BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.
Breous E, Somanathan S, Wilson JM. Breous E, et al. Mol Ther. 2010 Apr;18(4):766-74. doi: 10.1038/mt.2009.301. Epub 2010 Jan 12. Mol Ther. 2010. PMID: 20068550 Free PMC article.
Following adeno-associated virus (AAV) gene transfer to the liver, both C57BL/6 and BALB/c mice show long-term expression of nonself transgene antigens along with the absence of a transgene-specific immune response. ...
Following adeno-associated virus (AAV) gene transfer to the liver, both C57BL/6 and BALB/c mice show long-term expression of nonself …
Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer.
Rivera VM, Gao GP, Grant RL, Schnell MA, Zoltick PW, Rozamus LW, Clackson T, Wilson JM. Rivera VM, et al. Blood. 2005 Feb 15;105(4):1424-30. doi: 10.1182/blood-2004-06-2501. Epub 2004 Oct 26. Blood. 2005. PMID: 15507527 Free article.
We evaluated the ability of the dimerizer-regulated gene expression system to achieve controlled, long-term production of erythropoietin (Epo) following intramuscular administration of adeno-associated virus (AAV) vectors to 16 primates. ...
We evaluated the ability of the dimerizer-regulated gene expression system to achieve controlled, long-term production of erythropoie …