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Year Number of Results
2011 1
2012 3
2013 7
2014 7
2015 2
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2017 2
2018 2
2020 1
2024 0

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22 results

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Page 1
FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia.
Govindarajah V, Lee JM, Solomon M, Goddard B, Nayak R, Nattamai K, Geiger H, Salomonis N, Cancelas JA, Reynaud D. Govindarajah V, et al. Blood Adv. 2020 Nov 10;4(21):5512-5526. doi: 10.1182/bloodadvances.2020001826. Blood Adv. 2020. PMID: 33166407 Free PMC article.
Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism's lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated with systemic metabolic dis …
Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism's lifet …
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.
Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM. Serrano-Lopez J, et al. Exp Hematol. 2018 Mar;59:40-50.e3. doi: 10.1016/j.exphem.2017.12.009. Epub 2017 Dec 27. Exp Hematol. 2018. PMID: 29288703 Free PMC article.
Previous reports have indicated that the DEK protein, a chromatin structural protein that functions in numerous nuclear processes, is required for DNA damage repair in vitro and long-term engraftment of hematopoietic stem cells in vivo. Therefore, we investigated the role …
Previous reports have indicated that the DEK protein, a chromatin structural protein that functions in numerous nuclear processes, is requir …
A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.
Lin S, Ptasinska A, Chen X, Shrestha M, Assi SA, Chin PS, Imperato MR, Aronow BJ, Zhang J, Weirauch MT, Bonifer C, Mulloy JC. Lin S, et al. Blood. 2017 Sep 7;130(10):1213-1222. doi: 10.1182/blood-2016-11-750976. Epub 2017 Jul 14. Blood. 2017. PMID: 28710059 Free PMC article.
In agreement with this observation, genetic and pharmacological ablation of FOXO1 inhibited the long-term proliferation and clonogenicity of AE cells and t(8;21) AML cell lines. ...
In agreement with this observation, genetic and pharmacological ablation of FOXO1 inhibited the long-term proliferation and clonogeni …
Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.
Lin S, Wei J, Wunderlich M, Chou FS, Mulloy JC. Lin S, et al. Oncotarget. 2016 Aug 30;7(35):55939-55950. doi: 10.18632/oncotarget.11093. Oncotarget. 2016. PMID: 27509060 Free PMC article.
AE-hTERT cells retained cytokine dependency and multi-lineage differentiation potential similar to parental AE clones. Over the short-term, AE-hTERT cells did not show features of stepwise transformation, with no leukemogenecity evident upon initial injection into immunode …
AE-hTERT cells retained cytokine dependency and multi-lineage differentiation potential similar to parental AE clones. Over the short-ter …
Neonatal regulatory T cells have reduced capacity to suppress dendritic cell function.
Rueda CM, Moreno-Fernandez ME, Jackson CM, Kallapur SG, Jobe AH, Chougnet CA. Rueda CM, et al. Eur J Immunol. 2015 Sep;45(9):2582-92. doi: 10.1002/eji.201445371. Epub 2015 Jun 25. Eur J Immunol. 2015. PMID: 26046326 Free PMC article.
Despite the importance of this Treg-cell function, the capacity of Treg cells from term and preterm neonates to suppress DCs, and the suppressive mechanisms they use, are still undefined. ...In addition, CTLA-4 and cAMP were the main suppressive molecules used by neonatal …
Despite the importance of this Treg-cell function, the capacity of Treg cells from term and preterm neonates to suppress DCs, and the …
p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.
Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA. Chang KH, et al. Cell Rep. 2014 Dec 24;9(6):2084-97. doi: 10.1016/j.celrep.2014.11.031. Epub 2014 Dec 18. Cell Rep. 2014. PMID: 25533346 Free PMC article.
Consequently, Ob p62-deficient mice lose bone, Ob Ccl4 expression, and HP chemotaxis toward Cxcl12, resulting in egress of short-term hematopoietic stem cells and myeloid progenitors. Finally, Ccl4 expression and myeloid progenitor egress are reversed by deficiency of the …
Consequently, Ob p62-deficient mice lose bone, Ob Ccl4 expression, and HP chemotaxis toward Cxcl12, resulting in egress of short-term …
Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates.
Rueda CM, Wells CB, Gisslen T, Jobe AH, Kallapur SG, Chougnet CA. Rueda CM, et al. Hum Immunol. 2015 Jan;76(1):65-73. doi: 10.1016/j.humimm.2014.10.016. Epub 2014 Nov 8. Hum Immunol. 2015. PMID: 25451985 Free PMC article.
Treg from preterm newborns were less suppressive than Treg from adults or term, and the level of suppression was reduced with severe chorio. Relative to term, Treg frequency and phenotype were not affected by prematurity and chorio but their functionality was decrea …
Treg from preterm newborns were less suppressive than Treg from adults or term, and the level of suppression was reduced with severe …
Establishment of Gastrointestinal Epithelial Organoids.
Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, Sato T, Shroyer NF. Mahe MM, et al. Curr Protoc Mouse Biol. 2013 Dec 19;3(4):217-40. doi: 10.1002/9780470942390.mo130179. Curr Protoc Mouse Biol. 2013. PMID: 25105065 Free PMC article.
Primary cell cultures have proven to be promising for unraveling the mechanisms involved in epithelium homeostasis. In 2009, Sato et al. established a long-term primary culture to generate epithelial organoids (enteroids) with crypt- and villus-like epithelial domains repr …
Primary cell cultures have proven to be promising for unraveling the mechanisms involved in epithelium homeostasis. In 2009, Sato et al. est …
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J. Kong G, et al. J Clin Invest. 2014 Jun;124(6):2762-73. doi: 10.1172/JCI74182. Epub 2014 May 8. J Clin Invest. 2014. PMID: 24812670 Free PMC article.
In contrast, combined inhibition of MEK and JAK/STAT signaling, which is commonly hyperactivated in human and mouse CMML, potently inhibited human and mouse CMML cell growth in vitro, rescued mutant NrasG12D/G12D-expressing HSC function in vivo, and promoted long-term surv …
In contrast, combined inhibition of MEK and JAK/STAT signaling, which is commonly hyperactivated in human and mouse CMML, potently inhibited …
22 results