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2010 1
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52 results

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Page 1
Defining the T cell transcriptional landscape in pediatric liver transplant rejection at single cell resolution.
Peters AL, DePasquale EAK, Begum G, Roskin KM, Woodle ES, Hildeman DA. Peters AL, et al. bioRxiv [Preprint]. 2024 Feb 29:2024.02.26.582173. doi: 10.1101/2024.02.26.582173. bioRxiv. 2024. PMID: 38464256 Free PMC article. Preprint.
Therefore, persistently-detected intragraft CD8(EXP) clones remain active despite ACR treatment and may contribute to long-term allograft fibrosis and failure of operational tolerance....
Therefore, persistently-detected intragraft CD8(EXP) clones remain active despite ACR treatment and may contribute to long-term allog …
PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.
Wagner ML, Ammann A, Piraino G, Wolfe V, O'Connor M, Lahni P, Ziady A, Zingarelli B. Wagner ML, et al. Shock. 2023 Jul 1;60(1):64-74. doi: 10.1097/SHK.0000000000002134. Epub 2023 Apr 21. Shock. 2023. PMID: 37079467
Methods: AMPKalpha1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution. In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscit …
Methods: AMPKalpha1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood an …
A dietary change to a high-fat diet initiates a rapid adaptation of the intestine.
Enriquez JR, McCauley HA, Zhang KX, Sanchez JG, Kalin GT, Lang RA, Wells JM. Enriquez JR, et al. Cell Rep. 2022 Nov 15;41(7):111641. doi: 10.1016/j.celrep.2022.111641. Cell Rep. 2022. PMID: 36384107 Free PMC article.
Long-term impacts of diet have been well studied; however, the immediate response of the intestinal epithelium to a change in nutrients remains poorly understood. ...
Long-term impacts of diet have been well studied; however, the immediate response of the intestinal epithelium to a change in nutrien …
Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.
Urban C, Hayes HV, Piraino G, Wolfe V, Lahni P, O'Connor M, Phares C, Zingarelli B. Urban C, et al. Front Immunol. 2022 Sep 2;13:984298. doi: 10.3389/fimmu.2022.984298. eCollection 2022. Front Immunol. 2022. PMID: 36119052 Free PMC article.
At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung. In long-term outcomes studies up to 7 days, co-treatment of colivel …
At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and acti …
Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome.
Shneider BL, Spino CA, Kamath BM, Magee JC, Ignacio RV, Huang S, Horslen SP, Molleston JP, Miethke AG, Kohli R, Leung DH, Jensen MK, Loomes KM, Karpen SJ, Mack C, Rosenthal P, Squires RH, Baker A, Rajwal S, Kelly D, Sokol RJ, Thompson RJ; for ChiLDReN and UK IMAGO/IMAGINE Investigators. Shneider BL, et al. Hepatol Commun. 2022 Aug;6(8):1922-1933. doi: 10.1002/hep4.1992. Epub 2022 Jun 7. Hepatol Commun. 2022. PMID: 35672955 Free PMC article.
Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases-Examination of cholestatic liver disease in Alagille syndrome.
Shneider BL, Kamath BM, Magee JC, Goodrich NP, Loomes KM, Ye W, Spino C, Alonso EM, Molleston JP, Bezerra JA, Wang KS, Karpen SJ, Horslen SP, Guthery SL, Rosenthal P, Squires RH, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN). Shneider BL, et al. Hepatol Commun. 2022 Aug;6(8):1910-1921. doi: 10.1002/hep4.1970. Epub 2022 May 4. Hepatol Commun. 2022. PMID: 35506349 Free PMC article.
The conduct of long-term conventional randomized clinical trials in rare diseases is very difficult, making evidenced-based drug development problematic. ...
The conduct of long-term conventional randomized clinical trials in rare diseases is very difficult, making evidenced-based drug deve …
Soluble CD163 Identifies Those at Risk for Increased Hepatic Inflammation & Fibrosis.
Sherman KE, Meeds HL, Rouster SD, Abdel-Hameed EA, Hernandez J, Tamargo J, Chen J, Ehman RL, Baum M. Sherman KE, et al. Open Forum Infect Dis. 2021 Apr 22;8(6):ofab203. doi: 10.1093/ofid/ofab203. eCollection 2021 Jun. Open Forum Infect Dis. 2021. PMID: 34104667 Free PMC article.
In PWH, sCD163 is highly associated with both injury and fibrosis, suggesting that persistent systemic immune activation is a major contributor to long-term outcomes, adding to damage caused by alcohol, steatosis, and other hepatotoxic drug effects....
In PWH, sCD163 is highly associated with both injury and fibrosis, suggesting that persistent systemic immune activation is a major contribu …
An integrated microfluidic bubble pocket for long-term perfused three-dimensional intestine-on-a-chip model.
Lee KKP, Matsu-Ura T, Rosselot AE, Broda TR, Wells JM, Hong CI. Lee KKP, et al. Biomicrofluidics. 2021 Feb 17;15(1):014110. doi: 10.1063/5.0036527. eCollection 2021 Jan. Biomicrofluidics. 2021. PMID: 33643512 Free PMC article.
Perfused three-dimensional (3D) cultures enable long-term in situ growth and monitoring of 3D organoids making them well-suited for investigating organoid development, growth, and function. One of the limitations of this long-term on-chip perfused 3D culture is unin …
Perfused three-dimensional (3D) cultures enable long-term in situ growth and monitoring of 3D organoids making them well-suited for i …
Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease.
Ta AD, Ollberding NJ, Karns R, Haberman Y, Alazraki AL, Hercules D, Baldassano R, Markowitz J, Heyman MB, Kim S, Kirschner B, Shapiro JM, Noe J, Oliva-Hemker M, Otley A, Pfefferkorn M, Kellermayer R, Snapper S, Rabizadeh S, Xavier R, Dubinsky M, Hyams J, Kugathasan S, Jegga AG, Dillman JR, Denson LA. Ta AD, et al. Inflamm Bowel Dis. 2021 Oct 20;27(11):1707-1718. doi: 10.1093/ibd/izaa339. Inflamm Bowel Dis. 2021. PMID: 33452801 Free PMC article.
BACKGROUND: Transmural healing (TH) is associated with better long-term outcomes in Crohn disease (CD), whereas pretreatment ileal gene signatures encoding myeloid inflammatory responses and extracellular matrix production are associated with stricturing. ...
BACKGROUND: Transmural healing (TH) is associated with better long-term outcomes in Crohn disease (CD), whereas pretreatment ileal ge …
Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells.
Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T. Koike H, et al. Nat Protoc. 2021 Feb;16(2):919-936. doi: 10.1038/s41596-020-00441-w. Epub 2021 Jan 11. Nat Protoc. 2021. PMID: 33432231 Free PMC article.
., HBP) domains occurs within the boundary region of the two spheroids, even in the absence of any extrinsic factors. Long-term culture of HBP structures induces differentiation of the domains into segregated organs complete with developmentally relevant invagination and e …
., HBP) domains occurs within the boundary region of the two spheroids, even in the absence of any extrinsic factors. Long-term cultu …
52 results