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Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy.
Lee RE, Mascenik TM, Major SC, Galiger JR, Bulik-Sullivan E, Siesser PF, Lewis CA, Bear JE, Le Suer JA, Hawkins FJ, Pickles RJ, Randell SH. Lee RE, et al. Am J Physiol Lung Cell Mol Physiol. 2024 Mar 1;326(3):L226-L238. doi: 10.1152/ajplung.00421.2022. Epub 2023 Dec 27. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 38150545
We compared three injury models and determined that severe injury with partial epithelial denudation facilitates long-term cell engraftment and functional CFTR recovery up to 20% of wildtype function. ...
We compared three injury models and determined that severe injury with partial epithelial denudation facilitates long-term cell engra …
Bik promotes proteasomal degradation to control low-grade inflammation.
Mebratu YA, Jones JT, Liu C, Negasi ZH, Rahman M, Rojas-Quintero J, O'Connor GT, Gao W, Dupuis J, Cho MH, Litonjua AA, Randell S, Tesfaigzi Y. Mebratu YA, et al. J Clin Invest. 2023 Dec 19;134(4):e170594. doi: 10.1172/JCI170594. J Clin Invest. 2023. PMID: 38113109 Free PMC article.
Although chronic low-grade inflammation does not cause immediate clinical symptoms, over the longer term, it can enhance other insults or age-dependent damage to organ systems and thereby contribute to age-related disorders, such as respiratory disorders, heart disease, me …
Although chronic low-grade inflammation does not cause immediate clinical symptoms, over the longer term, it can enhance other insult …
Modeling insights into SARS-CoV-2 respiratory tract infections prior to immune protection.
Chen A, Wessler T, Daftari K, Hinton K, Boucher RC, Pickles R, Freeman R, Lai SK, Forest MG. Chen A, et al. Biophys J. 2022 May 3;121(9):1619-1631. doi: 10.1016/j.bpj.2022.04.003. Epub 2022 Apr 2. Biophys J. 2022. PMID: 35378080 Free PMC article.
We apply this baseline model in the absence of immune protection to explore immediate, short-term outcomes from novel SARS-CoV-2 depositions onto the air-ASL interface. ...
We apply this baseline model in the absence of immune protection to explore immediate, short-term outcomes from novel SARS-CoV-2 depo …
Generation of renewable mouse intestinal epithelial cell monolayers and organoids for functional analyses.
Moorefield EC, Blue RE, Quinney NL, Gentzsch M, Ding S. Moorefield EC, et al. BMC Cell Biol. 2018 Aug 15;19(1):15. doi: 10.1186/s12860-018-0165-0. BMC Cell Biol. 2018. PMID: 30111276 Free PMC article.
RESULTS: IEC monolayers form epithelial colonies that proliferate on a feeder cell layer and are able to maintain their genotype over long-term passage. IEC monolayers form 3D spheroids in matrigel culture and monolayers on transwell inserts making them useful for function …
RESULTS: IEC monolayers form epithelial colonies that proliferate on a feeder cell layer and are able to maintain their genotype over long- …
Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT.
Blackmon RL, Kreda SM, Sears PR, Chapman BS, Hill DB, Tracy JB, Ostrowski LE, Oldenburg AL. Blackmon RL, et al. Nanoscale. 2017 Apr 13;9(15):4907-4917. doi: 10.1039/c7nr00376e. Nanoscale. 2017. PMID: 28358158 Free PMC article.
In this study, we demonstrate the applicability of DS-OCT on well-differentiated primary human bronchial epithelial cells during a clinical mucus-hydrating therapy, hypertonic saline treatment (HST), to reveal, for the first time, mucus mixing, cellular secretions, and mucus hydr …
In this study, we demonstrate the applicability of DS-OCT on well-differentiated primary human bronchial epithelial cells during a clinical …
Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis.
Cholon DM, Quinney NL, Fulcher ML, Esther CR Jr, Das J, Dokholyan NV, Randell SH, Boucher RC, Gentzsch M. Cholon DM, et al. Sci Transl Med. 2014 Jul 23;6(246):246ra96. doi: 10.1126/scitranslmed.3008680. Sci Transl Med. 2014. PMID: 25101886 Free PMC article.
These findings demonstrate that chronic treatment with CFTR potentiators and correctors may have unexpected effects that cannot be predicted from short-term studies. Combining these drugs to maximize rescue of deltaF508 CFTR may require changes in dosing and/or development …
These findings demonstrate that chronic treatment with CFTR potentiators and correctors may have unexpected effects that cannot be predicted …
Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis.
Ostrowski LE, Yin W, Rogers TD, Busalacchi KB, Chua M, O'Neal WK, Grubb BR. Ostrowski LE, et al. Am J Respir Cell Mol Biol. 2010 Jul;43(1):55-63. doi: 10.1165/rcmb.2009-0118OC. Epub 2009 Aug 12. Am J Respir Cell Mol Biol. 2010. PMID: 19675306 Free PMC article.
Studies of primary ciliary dyskinesia (PCD) have been hampered by the lack of a suitable animal model because disruption of essential ciliary genes in mice results in a high incidence of lethal hydrocephalus. To develop a viable mouse model for long-term studies of PCD, we …
Studies of primary ciliary dyskinesia (PCD) have been hampered by the lack of a suitable animal model because disruption of essential ciliar …