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Single-cell genomics for dissection of complex malaria infections.
Nair S, Nkhoma SC, Serre D, Zimmerman PA, Gorena K, Daniel BJ, Nosten F, Anderson TJ, Cheeseman IH. Nair S, et al. Genome Res. 2014 Jun;24(6):1028-38. doi: 10.1101/gr.168286.113. Epub 2014 May 8. Genome Res. 2014. PMID: 24812326 Free PMC article.
We applied this validated approach directly to infections of two major malaria species, Plasmodium falciparum, for which long term culture is possible, and Plasmodium vivax, for which no long-term culture is feasible. ...
We applied this validated approach directly to infections of two major malaria species, Plasmodium falciparum, for which long term cu …
Rapamycin treatment improves neuron viability in an in vitro model of stroke.
Fletcher L, Evans TM, Watts LT, Jimenez DF, Digicaylioglu M. Fletcher L, et al. PLoS One. 2013 Jul 4;8(7):e68281. doi: 10.1371/journal.pone.0068281. Print 2013. PLoS One. 2013. PMID: 23861877 Free PMC article.
Ischemic stroke is the leading cause of serious, long-term adult disability and is associated with sensorimotor and cognitive impairments due to neuronal degeneration. ...
Ischemic stroke is the leading cause of serious, long-term adult disability and is associated with sensorimotor and cognitive impairm …
Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals.
Chavez AO, Kamath S, Jani R, Sharma LK, Monroy A, Abdul-Ghani MA, Centonze VE, Sathyanarayana P, Coletta DK, Jenkinson CP, Bai Y, Folli F, Defronzo RA, Tripathy D. Chavez AO, et al. J Clin Endocrinol Metab. 2010 Jan;95(1):422-9. doi: 10.1210/jc.2009-1387. Epub 2009 Oct 28. J Clin Endocrinol Metab. 2010. PMID: 19864449 Free PMC article. Clinical Trial.
No significant changes in genes expression, citrate synthase activity, and total ATP content were observed after either lipid or saline infusion. CONCLUSIONS: Short-term physiological increase in plasma FFA concentration in lean normal glucose tolerant subjects induces ins …
No significant changes in genes expression, citrate synthase activity, and total ATP content were observed after either lipid or saline infu …
Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells.
Lai Y, Sun Y, Skinner CM, Son EL, Lu Z, Tuan RS, Jilka RL, Ling J, Chen XD. Lai Y, et al. Stem Cells Dev. 2010 Jul;19(7):1095-107. doi: 10.1089/scd.2009.0217. Stem Cells Dev. 2010. PMID: 19737070 Free PMC article.
The difficulty in long-term expansion of mesenchymal stem cells (MSCs) using standard culture systems without the loss of their stem cell properties suggests that a critical feature of their microenvironment necessary for retention of stem cell properties is absent in thes …
The difficulty in long-term expansion of mesenchymal stem cells (MSCs) using standard culture systems without the loss of their stem …
Total prostate specific antigen stability confirmed after long-term storage of serum at -80C.
Reed AB, Ankerst DP, Leach RJ, Vipraio G, Thompson IM, Parekh DJ. Reed AB, et al. J Urol. 2008 Aug;180(2):534-7; discussion 537-8. doi: 10.1016/j.juro.2008.04.021. Epub 2008 Jun 11. J Urol. 2008. PMID: 18550121
PURPOSE: We characterized the long-term stability of total prostate specific antigen in serum samples after storage at -80C from 2001 until 2007. ...
PURPOSE: We characterized the long-term stability of total prostate specific antigen in serum samples after storage at -80C from 2001 …
Improving cell therapy--experiments using transplanted telomerase-immortalized cells in immunodeficient mice.
Huang Q, Chen M, Liang S, Acha V, Liu D, Yuan F, Hawks CL, Hornsby PJ. Huang Q, et al. Mech Ageing Dev. 2007 Jan;128(1):25-30. doi: 10.1016/j.mad.2006.11.006. Epub 2006 Nov 22. Mech Ageing Dev. 2007. PMID: 17123586 Free PMC article. Review.
Two issues that must be addressed before cell therapy could be used routinely in medicine are improved efficacy of the transplanted cells and demonstrated long-term safety. Desirable genetic modifications that could be made to cells to be used for cell therapy include immo …
Two issues that must be addressed before cell therapy could be used routinely in medicine are improved efficacy of the transplanted cells an …
Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy.
Oyajobi BO, Anderson DM, Traianedes K, Williams PJ, Yoneda T, Mundy GR. Oyajobi BO, et al. Cancer Res. 2001 Mar 15;61(6):2572-8. Cancer Res. 2001. PMID: 11289133
The in vitro studies demonstrated the ability of muRANK.Fc to inhibit human parathyroid hormone-related protein (PTHrP)-induced resorption in fetal rat long bone cultures. Short-term administration of muRANK.Fc to normal growing mice resulted in a complete disappearance of …
The in vitro studies demonstrated the ability of muRANK.Fc to inhibit human parathyroid hormone-related protein (PTHrP)-induced resorption i …
Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer.
Harvey JM, Clark GM, Osborne CK, Allred DC. Harvey JM, et al. J Clin Oncol. 1999 May;17(5):1474-81. doi: 10.1200/JCO.1999.17.5.1474. J Clin Oncol. 1999. PMID: 10334533 Corrected and republished.
The purpose of this study was to evaluate the ability of ER status determination by IHC, compared with LBA, to predict clinical outcome-especially response to adjuvant endocrine therapy-in a large number of patients with long-term clinical follow-up. PATIENTS AND METHODS: …
The purpose of this study was to evaluate the ability of ER status determination by IHC, compared with LBA, to predict clinical outcome-espe …
Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer.
Brown RW, Allred CD, Clark GM, Osborne CK, Hilsenbeck SG. Brown RW, et al. Clin Cancer Res. 1996 Mar;2(3):585-92. Clin Cancer Res. 1996. PMID: 9816207
The primary purpose of this study was to evaluate the prognostic significance of Ki-67, a cell proliferation-associated antigen, in a large group (n = 674) of axillary node-negative breast cancer cases with long-term follow-up and to correlate Ki-67 antigen expression with …
The primary purpose of this study was to evaluate the prognostic significance of Ki-67, a cell proliferation-associated antigen, in a large …