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45 results

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Reactivation of Epstein-Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites on the Viral Genome.
Dunn LEM, Lu F, Su C, Lieberman PM, Baines JD. Dunn LEM, et al. J Virol. 2023 Feb 28;97(2):e0189422. doi: 10.1128/jvi.01894-22. Epub 2023 Feb 6. J Virol. 2023. PMID: 36744959 Free PMC article.
The ability of Epstein-Barr virus (EBV) to switch between latent and lytic infection is key to its long-term persistence, yet the molecular mechanisms behind this switch remain unclear. ...IMPORTANCE The ability of EBV to switch between latent and lytic infection is key to …
The ability of Epstein-Barr virus (EBV) to switch between latent and lytic infection is key to its long-term persistence, yet the mol …
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer.
Mirji G, Worth A, Bhat SA, El Sayed M, Kannan T, Goldman AR, Tang HY, Liu Q, Auslander N, Dang CV, Abdel-Mohsen M, Kossenkov A, Stanger BZ, Shinde RS. Mirji G, et al. Sci Immunol. 2022 Sep 9;7(75):eabn0704. doi: 10.1126/sciimmunol.abn0704. Epub 2022 Sep 9. Sci Immunol. 2022. PMID: 36083892 Free PMC article.
Last, the levels of bacteria containing CutC (an enzyme that generates trimethylamine, the TMAO precursor) correlated with long-term survival in patients with PDAC and improved response to anti-PD1 in patients with melanoma. ...
Last, the levels of bacteria containing CutC (an enzyme that generates trimethylamine, the TMAO precursor) correlated with long-term …
PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery.
Koc S, Lloyd MW, Grover JW, Xiao N, Seepo S, Subramanian SL, Ray M, Frech C, DiGiovanna J, Webster P, Neuhauser S, Srivastava A, Woo XY, Sanderson BJ, White B, Lott P, Dobrolecki LE, Dowst H; PDXNet Consortium; Evrard YA, Wallace TA, Moscow JA, Doroshow JH, Mitsiades N, Kaochar S, Pan CX, Chen MS, Carvajal-Carmona L, Welm AL, Welm BE, Lewis MT, Govindan R, Ding L, Li S, Herlyn M, Davies MA, Roth J, Meric-Bernstam F, Robinson PN, Bult CJ, Davis-Dusenbery B, Dean DA 2nd, Chuang JH. Koc S, et al. NAR Cancer. 2022 Apr 22;4(2):zcac014. doi: 10.1093/narcan/zcac014. eCollection 2022 Jun. NAR Cancer. 2022. PMID: 35475145 Free PMC article.
These models have 2134 associated sequencing files from 873 samples across 308 patients, which are hosted on the Cancer Genomics Cloud powered by Seven Bridges and the NCI Cancer Data Service for long-term storage and access with dbGaP permissions. The portal includes resu …
These models have 2134 associated sequencing files from 873 samples across 308 patients, which are hosted on the Cancer Genomics Cloud power …
Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.
Vásquez-Trincado C, Patel M, Sivaramakrishnan A, Bekeová C, Anderson-Pullinger L, Wang N, Tang HY, Seifert EL. Vásquez-Trincado C, et al. Hum Mol Genet. 2021 Sep 22;33(8):637-54. doi: 10.1093/hmg/ddab216. Online ahead of print. Hum Mol Genet. 2021. PMID: 34550363 Free PMC article.
Altogether, these findings suggest that the FXN depleted heart can suppress a major ATP demanding process such as protein translation, which, together with some preservation of beta-oxidation, could be adaptive, at least in the short term....
Altogether, these findings suggest that the FXN depleted heart can suppress a major ATP demanding process such as protein translation, which …
A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation.
Bhojnagarwala PS, Perales-Puchalt A, Cooch N, Sardesai NY, Weiner DB. Bhojnagarwala PS, et al. Mol Ther Oncolytics. 2021 Apr 16;21:278-287. doi: 10.1016/j.omto.2021.04.005. eCollection 2021 Jun 25. Mol Ther Oncolytics. 2021. PMID: 34141866 Free PMC article.
Different vaccines elicited T cell responses against multiple epitopes on the vaccine string and controlled growth of multi-focal, heterogeneous tumors in a therapeutic tumor challenge. Additionally, the multi-epitope antigens induced long-term immunity and rejected a tumo …
Different vaccines elicited T cell responses against multiple epitopes on the vaccine string and controlled growth of multi-focal, heterogen …
EBNA1 inhibitors have potent and selective antitumor activity in xenograft models of Epstein-Barr virus-associated gastric cancer.
Soldan SS, Anderson EM, Frase DM, Zhang Y, Caruso LB, Wang Y, Deakyne JS, Gewurz BE, Tempera I, Lieberman PM, Messick TE. Soldan SS, et al. Gastric Cancer. 2021 Sep;24(5):1076-1088. doi: 10.1007/s10120-021-01193-6. Epub 2021 Apr 30. Gastric Cancer. 2021. PMID: 33929613 Free PMC article.
In animal studies, treatment with an EBNA1 inhibitor resulted in a significant dose-dependent decrease in tumor growth in EBVaGC xenograft models, but not in EBV-negative GC xenograft studies. Gene expression analysis revealed that short term treatment in cell culture tend …
In animal studies, treatment with an EBNA1 inhibitor resulted in a significant dose-dependent decrease in tumor growth in EBVaGC xenograft m …
Epstein-Barr Virus Infection in the Development of Neurological Disorders.
Soldan SS, Lieberman PM. Soldan SS, et al. Drug Discov Today Dis Models. 2020 Fall;32(Pt A):35-52. doi: 10.1016/j.ddmod.2020.01.001. Epub 2020 Feb 19. Drug Discov Today Dis Models. 2020. PMID: 33897799 Free PMC article.
Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus that contributes to the etiology of diverse human cancers and auto-immune diseases. EBV establishes a relatively benign, long-term latent infection in over 90 percent of the adult population. ...
Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus that contributes to the etiology of diverse human cancers and auto-immune disease …
Persons who inject drugs (PWID) retain functional NK cells, dendritic cell stimulation, and adaptive immune recall responses despite prolonged opioid use.
Tomescu C, Colon K, Smith P, Taylor M, Azzoni L, Metzger DS, Montaner LJ. Tomescu C, et al. J Leukoc Biol. 2020 Dec 2:10.1002/JLB.5A0920-604R. doi: 10.1002/JLB.5A0920-604R. Online ahead of print. J Leukoc Biol. 2020. PMID: 33289158 Free PMC article.
Here, we assessed if innate and adaptive immune responses are compromised ex vivo in persons who inject drugs (PWID) and whether long-term injection drug use may impact host susceptibility to in vitro HIV infection. ...
Here, we assessed if innate and adaptive immune responses are compromised ex vivo in persons who inject drugs (PWID) and whether long-ter …
Durability of response to VGX-3100 treatment of HPV16/18 positive cervical HSIL.
Bhuyan PK, Dallas M, Kraynyak K, Herring T, Morrow M, Boyer J, Duff S, Kim J, Weiner DB. Bhuyan PK, et al. Hum Vaccin Immunother. 2021 May 4;17(5):1288-1293. doi: 10.1080/21645515.2020.1823778. Epub 2020 Nov 11. Hum Vaccin Immunother. 2021. PMID: 33175656 Free PMC article. Clinical Trial.
The presence of HPV16/18, Pap smear diagnoses, and immunogenicity longer-term responses were assessed at 18 months after the last dose.91% (32/35) VGX-3100-treated women, whose cervical HSIL regressed and avoided excision at 6 months following study treatment completion, h …
The presence of HPV16/18, Pap smear diagnoses, and immunogenicity longer-term responses were assessed at 18 months after the last dos …
45 results