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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 2
2008 6
2009 6
2010 14
2011 13
2012 21
2013 28
2014 15
2015 15
2016 22
2017 28
2018 19
2019 20
2020 17
2021 9
2022 8
2023 1
2024 0

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199 results

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Page 1
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
Efron PA, Brakenridge SC, Mohr AM, Barrios EL, Polcz VE, Anton S, Ozrazgat-Baslanti T, Bihorac A, Guirgis F, Loftus TJ, Rosenthal M, Leeuwenburgh C, Mankowski R, Moldawer LL, Moore FA. Efron PA, et al. J Trauma Acute Care Surg. 2023 Nov 1;95(5):790-799. doi: 10.1097/TA.0000000000004087. Epub 2023 Aug 8. J Trauma Acute Care Surg. 2023. PMID: 37561664
In 2012, the University of Florida (UF) Sepsis Critical Illness Research Center (SCIRC) coined the term Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) to provide a mechanistic framework to study CCI in surgical patients. This was followed by a d …
In 2012, the University of Florida (UF) Sepsis Critical Illness Research Center (SCIRC) coined the term Persistent Inflammation, Immu …
Characterizing OPRM1 DNA methylation in prescription opioid users with chronic musculoskeletal pain.
Sheikh S, Smotherman C, Patel M, Langaee T, Wang D, Swaray E, Velasquez E, Schmidt SOF, Hendry P, Cavallari LH, Fillingim RB. Sheikh S, et al. Pain Rep. 2022 Nov 24;7(6):e1046. doi: 10.1097/PR9.0000000000001046. eCollection 2022 Nov-Dec. Pain Rep. 2022. PMID: 36447952 Free PMC article.
OBJECTIVE: Our objective was to investigate associations of clinical and sociodemographic factors with OPRM1 DNA methylation in patients with chronic musculoskeletal pain on long-term prescription opioids. METHODS: Sociodemographic variables, survey data (Rapid Estimate of …
OBJECTIVE: Our objective was to investigate associations of clinical and sociodemographic factors with OPRM1 DNA methylation in patients wit …
Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis.
Rincon JC, Efron PA, Moldawer LL. Rincon JC, et al. J Leukoc Biol. 2022 Dec;112(6):1525-1534. doi: 10.1002/JLB.4MR0922-690RR. Epub 2022 Oct 4. J Leukoc Biol. 2022. PMID: 36193662 Free PMC article. Review.
Although earlier detection and improved treatment bundles have reduced in-hospital mortality, long-term recovery remains dismal. Sepsis survivors who experience chronic critical illness often demonstrate persistent inflammation, immune suppression, lean tissue wasting, and …
Although earlier detection and improved treatment bundles have reduced in-hospital mortality, long-term recovery remains dismal. Seps …
Declining trend in use of medications for sleep disturbance in the United States from 2013 to 2018.
Kaufmann CN, Spira AP, Wickwire EM, Mojtabai R, Ancoli-Israel S, Fung CH, Malhotra A. Kaufmann CN, et al. J Clin Sleep Med. 2022 Oct 1;18(10):2459-2465. doi: 10.5664/jcsm.10132. J Clin Sleep Med. 2022. PMID: 35818727 Free PMC article.
This trend was driven by declines in use of Food and Drug Administration-approved medications for sleep disturbance, especially for medium- and long-term duration of use. Notably, among those age 80+ years, we observed an 86% decline (odds ratio = 0.14, 95% confidence inte …
This trend was driven by declines in use of Food and Drug Administration-approved medications for sleep disturbance, especially for medium- …
Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational study.
Braithwaite D, Karanth SD, Slatore CG, Zhang D, Bian J, Meza R, Jeon J, Tammemagi M, Schabath M, Wheeler M, Guo Y, Hochhegger B, Kaye FJ, Silvestri GA, Gould MK. Braithwaite D, et al. BMJ Open. 2022 Jun 22;12(6):e064142. doi: 10.1136/bmjopen-2022-064142. BMJ Open. 2022. PMID: 35732383 Free PMC article.
To our knowledge, this is the first study to combine observational data and simulation models to estimate the long-term impact of LCS with LDCT. ETHICS AND DISSEMINATION: The study was approved by the Kaiser Permanente Southern California Institutional Review Board and VA …
To our knowledge, this is the first study to combine observational data and simulation models to estimate the long-term impact of LCS …
Early Biomarker Signatures in Surgical Sepsis.
Madushani RWMA, Patel V, Loftus T, Ren Y, Li HJ, Velez L, Wu Q, Adhikari L, Efron P, Segal M, Ozrazgat-Baslanti T, Rashidi P, Bihorac A; Sepsis and Critical Illness Research Center Investigators. Madushani RWMA, et al. J Surg Res. 2022 Sep;277:372-383. doi: 10.1016/j.jss.2022.04.052. Epub 2022 May 12. J Surg Res. 2022. PMID: 35569215 Free PMC article.
We applied hierarchical clustering to clinical variables and 42 blood and urine biomarkers to identify phenotypic subgroups in a development cohort. Clinical characteristics and short-term and long-term outcomes were compared between clusters. A naive Bayes classifi …
We applied hierarchical clustering to clinical variables and 42 blood and urine biomarkers to identify phenotypic subgroups in a development …
Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming-A New Mechanism for SCLC Chemoresistance Boosted by Nicotine.
Wang Y, Bian T, Song L, Jiang Y, Huo Z, Salloum RG, Warren GW, Kaye FJ, Fujioka N, Jin L, Xing C. Wang Y, et al. Cancers (Basel). 2022 May 2;14(9):2272. doi: 10.3390/cancers14092272. Cancers (Basel). 2022. PMID: 35565402 Free PMC article.
Surprisingly, cisplatin treatment alone also increased the levels of nAChRs in SCLC cells, which served as a self-defense mechanism against platinum-based therapies. These discoveries were confirmed in long-term in vitro and in vivo studies. Collectively, our results depic …
Surprisingly, cisplatin treatment alone also increased the levels of nAChRs in SCLC cells, which served as a self-defense mechanism against …
Application of social cognitive theory in weight management: Time for a biological component?
Anton S, Das SK, McLaren C, Roberts SB. Anton S, et al. Obesity (Silver Spring). 2021 Dec;29(12):1982-1986. doi: 10.1002/oby.23257. Epub 2021 Oct 27. Obesity (Silver Spring). 2021. PMID: 34705335 Free PMC article.
Despite the utility of social cognitive theory for facilitating individual behavior changes needed for initial weight loss, this model has been less effective in facilitating adherence to recommended lifestyle changes required for sustainable weight-loss maintenance. One potentia …
Despite the utility of social cognitive theory for facilitating individual behavior changes needed for initial weight loss, this model has b …
Machine Learning Applications in Solid Organ Transplantation and Related Complications.
Balch JA, Delitto D, Tighe PJ, Zarrinpar A, Efron PA, Rashidi P, Upchurch GR Jr, Bihorac A, Loftus TJ. Balch JA, et al. Front Immunol. 2021 Sep 16;12:739728. doi: 10.3389/fimmu.2021.739728. eCollection 2021. Front Immunol. 2021. PMID: 34603324 Free PMC article. Review.
We summarize emerging evidence that recent advances that allow machine learning algorithms to predict acute post-surgical and long-term outcomes, classify biopsy and radiographic data, augment pharmacologic decision making, and accurately represent the complexity of host i …
We summarize emerging evidence that recent advances that allow machine learning algorithms to predict acute post-surgical and long-term …
Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline.
Barter J, Kumar A, Bean L, Ciesla M, Foster TC. Barter J, et al. Aging (Albany NY). 2021 Sep 29;13(18):22092-22108. doi: 10.18632/aging.203588. Epub 2021 Sep 29. Aging (Albany NY). 2021. PMID: 34587117 Free PMC article.
In order to understand the long-term effects of systemic inflammation, it is important to distinguish inflammation-induced changes in baseline cognitive function from changes that interact with aging to influence the trajectory of cognitive decline. ...Longitudinal effects …
In order to understand the long-term effects of systemic inflammation, it is important to distinguish inflammation-induced changes in …
199 results