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2008 1
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2013 3
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2023 1
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Page 1
Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson's disease.
Ge G, Sivasubramanian BP, Geng BD, Zhao S, Zhou Q, Huang G, O'Connor JC, Clark RA, Li S. Ge G, et al. Gene Ther. 2024 May;31(5-6):324-334. doi: 10.1038/s41434-024-00451-3. Epub 2024 Apr 16. Gene Ther. 2024. PMID: 38627469
Overall, this study provides compelling evidence for the long-term therapeutic efficacy and safety of HSC-based MMC-GDNF delivery in the treatment of PD....
Overall, this study provides compelling evidence for the long-term therapeutic efficacy and safety of HSC-based MMC-GDNF delivery in …
Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging.
Poudel SB, Frikha-Benayed D, Ruff RR, Yildirim G, Dixit M, Korstanje R, Robinson L, Miller RA, Harrison DE, Strong JR, Schaffler MB, Yakar S. Poudel SB, et al. Aging (Albany NY). 2024 Mar 25;16(6):4948-4964. doi: 10.18632/aging.205147. Epub 2024 Mar 25. Aging (Albany NY). 2024. PMID: 38535998 Free PMC article.
Mitoquinone (MitoQ) is a selective antioxidant that specifically targets mitochondria and effectively reduces the accumulation of reactive oxygen species. To investigate the effect of long-term administration of MB on skeletal morphology, we administered MB to aged (18 mon …
Mitoquinone (MitoQ) is a selective antioxidant that specifically targets mitochondria and effectively reduces the accumulation of reactive o …
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.
Espinoza SE, Khosla S, Baur JA, de Cabo R, Musi N. Espinoza SE, et al. J Gerontol A Biol Sci Med Sci. 2023 Jun 16;78(Suppl 1):53-60. doi: 10.1093/gerona/glad034. J Gerontol A Biol Sci Med Sci. 2023. PMID: 37325957
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and longer-term outcomes....
However, much further research is needed to demonstrate benefits and general safety for wider use, the appropriate target populations, and l …
Effect of acute TLR4 inhibition on insulin resistance in humans.
Liang H, Sathavarodom N, Colmenares C, Gelfond J, Espinoza SE, Ganapathy V, Musi N. Liang H, et al. J Clin Invest. 2022 Nov 1;132(21):e162291. doi: 10.1172/JCI162291. J Clin Invest. 2022. PMID: 36066991 Free PMC article.
Eritoran also failed to improve any baseline metabolic parameters (M, FPG, FPI, HOMA-IR) in individuals with obesity and insulin resistance (protocol II).ConclusionsAcute TLR4 inhibition with eritoran did not protect against lipid-induced insulin resistance. Short-term eri …
Eritoran also failed to improve any baseline metabolic parameters (M, FPG, FPI, HOMA-IR) in individuals with obesity and insulin resistance …
The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño-Enríquez MA, Bronner GN, Coen C, Delaney MA, Dengler-Crish CM, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Lewis Hardell KN, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O'Connor TP, Okanoya K, O'Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos-Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, Smith ESJ. Buffenstein R, et al. Biol Rev Camb Philos Soc. 2022 Feb;97(1):115-140. doi: 10.1111/brv.12791. Epub 2021 Sep 3. Biol Rev Camb Philos Soc. 2022. PMID: 34476892 Free PMC article. Review.
., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of which persist solely in the popular press; (ii) 'myths' that are based on incomplete understanding, where more evidence is clearly needed; (ii …
., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of wh …
Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study.
Ji N, Mukherjee N, Reyes RM, Gelfond J, Javors M, Meeks JJ, McConkey DJ, Shu ZJ, Ramamurthy C, Dennett R, Curiel TJ, Svatek RS. Ji N, et al. J Immunother Cancer. 2021 Mar;9(3):e001941. doi: 10.1136/jitc-2020-001941. J Immunother Cancer. 2021. PMID: 33653802 Free PMC article. Clinical Trial.
Rapamycin enhances BCG-specific gammadelta T cell immunity and boosts urinary cytokines during BCG treatment. Further study is needed to determine long-term rapamycin safety, tolerability and effects on BCG efficacy....
Rapamycin enhances BCG-specific gammadelta T cell immunity and boosts urinary cytokines during BCG treatment. Further study is needed to det …
Evaluation of the pharmacokinetics of metformin and acarbose in the common marmoset.
Fernandez E, Ross C, Liang H, Javors M, Tardif S, Salmon AB. Fernandez E, et al. Pathobiol Aging Age Relat Dis. 2019 Aug 22;9(1):1657756. doi: 10.1080/20010001.2019.1657756. eCollection 2019. Pathobiol Aging Age Relat Dis. 2019. PMID: 31497263 Free PMC article.
The ability to rapidly and reliably dose socially housed marmosets with an oral form of acarbose or metformin that is well tolerated indicates that this species is a reliable model for testing acarbose and metformin in a safe and efficient way in a long-term intervention.. …
The ability to rapidly and reliably dose socially housed marmosets with an oral form of acarbose or metformin that is well tolerated indicat …
Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets.
Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB. Sills AM, et al. Am J Primatol. 2019 Feb;81(2):e22927. doi: 10.1002/ajp.22927. Epub 2018 Oct 12. Am J Primatol. 2019. PMID: 30311681 Free PMC article.
These data then suggest that the potential clinical hematological side effects of rapamycin are not likely outcomes of long-term rapamycin in relatively healthy, middle-aged marmosets....
These data then suggest that the potential clinical hematological side effects of rapamycin are not likely outcomes of long-term rapa …
A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.
Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JAL, Kellogg DL Jr. Kraig E, et al. Exp Gerontol. 2018 May;105:53-69. doi: 10.1016/j.exger.2017.12.026. Epub 2018 Feb 3. Exp Gerontol. 2018. PMID: 29408453 Free PMC article. Clinical Trial.
Thus, based on the results of our pilot study, it appears that short-term RAPA treatment can be used safely in older persons who are otherwise healthy; a trial with a larger sample size and longer treatment duration is warranted....
Thus, based on the results of our pilot study, it appears that short-term RAPA treatment can be used safely in older persons who are …
24 results