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A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair.
Wysoczynski M, Bolli R. Wysoczynski M, et al. Eur Heart J. 2020 Jul 1;41(25):2397-2404. doi: 10.1093/eurheartj/ehz787. Eur Heart J. 2020. PMID: 31778154 Free PMC article.
Although ESCs and ESC-derived cells were touted as capable of long-term regeneration, these cells disappear rapidly after transplantation and there is no evidence of long-term engraftment, let alone regeneration. ...
Although ESCs and ESC-derived cells were touted as capable of long-term regeneration, these cells disappear rapidly after transplanta …
Glutathione S-transferase P deficiency induces glucose intolerance via JNK-dependent enhancement of hepatic gluconeogenesis.
Ghosh Dastidar S, Jagatheesan G, Haberzettl P, Shah J, Hill BG, Bhatnagar A, Conklin DJ. Ghosh Dastidar S, et al. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E1005-E1018. doi: 10.1152/ajpendo.00345.2017. Epub 2018 Aug 28. Am J Physiol Endocrinol Metab. 2018. PMID: 30153066 Free PMC article.
Herein, we tested whether GSTP deficiency disturbs glucose homeostasis in mice. Hepatic GST proteins were downregulated by short-term high-fat diet in wild-type (WT) mice concomitant with increased glucose intolerance, JNK activation, and cytokine mRNAs in the liver. ...
Herein, we tested whether GSTP deficiency disturbs glucose homeostasis in mice. Hepatic GST proteins were downregulated by short-term …
Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.
Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW. Qian H, et al. Sci Signal. 2017 Jan 24;10(463):eaaf9659. doi: 10.1126/scisignal.aaf9659. Sci Signal. 2017. PMID: 28119465 Free PMC article.
We report that augmentation of L-type currents by PKA in neurons was absent in S1928A KI mice. Furthermore, S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Ca(v)1.2 and enh …
We report that augmentation of L-type currents by PKA in neurons was absent in S1928A KI mice. Furthermore, S1928A KI mice failed to induce …
Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress.
Haberzettl P, O'Toole TE, Bhatnagar A, Conklin DJ. Haberzettl P, et al. Environ Health Perspect. 2016 Dec;124(12):1830-1839. doi: 10.1289/EHP212. Epub 2016 Apr 29. Environ Health Perspect. 2016. PMID: 27128347 Free PMC article.
Treatment with the antioxidant TEMPOL or lung-specific overexpression of ecSOD prevented CAP-induced vascular insulin resistance and inflammation. CONCLUSIONS: Short-term exposure to PM2.5 induces vascular insulin resistance and inflammation triggered by a mechanism involv …
Treatment with the antioxidant TEMPOL or lung-specific overexpression of ecSOD prevented CAP-induced vascular insulin resistance and inflamm …
Short-term physical inactivity impairs vascular function.
Nosova EV, Yen P, Chong KC, Alley HF, Stock EO, Quinn A, Hellmann J, Conte MS, Owens CD, Spite M, Grenon SM. Nosova EV, et al. J Surg Res. 2014 Aug;190(2):672-82. doi: 10.1016/j.jss.2014.02.001. Epub 2014 Feb 12. J Surg Res. 2014. PMID: 24630521 Free PMC article.
It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term exposure to inactivity would lead to endothelial dysfunction, arterial stiffening, and increased vascular inflammation. ...
It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term …
Cardiomyocyte Ogt is essential for postnatal viability.
Watson LJ, Long BW, DeMartino AM, Brittian KR, Readnower RD, Brainard RE, Cummins TD, Annamalai L, Hill BG, Jones SP. Watson LJ, et al. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H142-53. doi: 10.1152/ajpheart.00438.2013. Epub 2013 Nov 1. Am J Physiol Heart Circ Physiol. 2014. PMID: 24186210 Free PMC article.
Additional groups of mice were subjected to inducible deletion of cmOGT, which did not produce overt dysfunction within the first couple of weeks of deletion. Yet, long-term loss (via inducible deletion) of cmOGT produced gradual and progressive cardiomyopathy. ...
Additional groups of mice were subjected to inducible deletion of cmOGT, which did not produce overt dysfunction within the first couple of …