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Oocyte quality is enhanced by hypoglycosylated FSH through increased cell-to-cell interaction during mouse follicle development.
Converse A, Liu Z, Patel JC, Shakyawar S, Guda C, Bousfield GR, Kumar TR, Duncan FE. Converse A, et al. Development. 2023 Nov 15;150(22):dev202170. doi: 10.1242/dev.202170. Epub 2023 Nov 10. Development. 2023. PMID: 37870089
To investigate whether the shift in FSH glycoform abundance contributes to the age-dependent decline in oocyte quality, the direct effects of FSH glycoforms on folliculogenesis and oocyte quality were determined using an encapsulated in vitro mouse follicle growth system. Long- …
To investigate whether the shift in FSH glycoform abundance contributes to the age-dependent decline in oocyte quality, the direct effects o …
Basic fibroblast growth factor induces proliferation and collagen production by fibroblasts derived from the bovine corpus luteum†.
Monaco CF, Plewes MR, Przygrodzka E, George JW, Qiu F, Xiao P, Wood JR, Cupp AS, Davis JS. Monaco CF, et al. Biol Reprod. 2023 Sep 12;109(3):367-380. doi: 10.1093/biolre/ioad065. Biol Reprod. 2023. PMID: 37283496
We observed rapid and robust phosphorylation of various signaling pathways involved in proliferation, such as ERK, AKT, and STAT1. From our longer-term treatments, we determined that FGF2 has a concentration-dependent collagen-inducing effect, and that FGF2 acts as a mitog …
We observed rapid and robust phosphorylation of various signaling pathways involved in proliferation, such as ERK, AKT, and STAT1. From our …
Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2.
Xia Z, Vellichirammal NN, Han L, Gao L, Boesen EI, Schiller AM, Pellegrino PR, Lisco SJ, Guda C, Zucker IH, Wang HJ. Xia Z, et al. JACC Basic Transl Sci. 2022 Jun 22;7(6):582-596. doi: 10.1016/j.jacbts.2022.02.008. eCollection 2022 Jun. JACC Basic Transl Sci. 2022. PMID: 35818505 Free PMC article.
Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protectiv …
Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and incr …
Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease.
Olson KE, Namminga KL, Lu Y, Schwab AD, Thurston MJ, Abdelmoaty MM, Kumar V, Wojtkiewicz M, Obaro H, Santamaria P, Mosley RL, Gendelman HE. Olson KE, et al. EBioMedicine. 2021 May;67:103380. doi: 10.1016/j.ebiom.2021.103380. Epub 2021 May 14. EBioMedicine. 2021. PMID: 34000620 Free PMC article. Clinical Trial.
Hypomethylation of upstream FOXP3 DNA elements was also increased. INTERPRETATION: Long-term sargramostim treatment at 3 mug/kg/day is well-tolerated and effective in restoring immune homeostasis. ...
Hypomethylation of upstream FOXP3 DNA elements was also increased. INTERPRETATION: Long-term sargramostim treatment at 3 mug/kg/day i …
Interaction of maternal immune activation and genetic interneuronal inhibition.
Anderson A, Genaro-Mattos TC, Allen LB, Koczok K, Korade Z, Mirnics K. Anderson A, et al. Brain Res. 2021 May 15;1759:147370. doi: 10.1016/j.brainres.2021.147370. Epub 2021 Feb 15. Brain Res. 2021. PMID: 33600830 Free PMC article.
We were interested to assess if maternal immune activation (MIA), genetic interneuronal inhibition, and the combination of these two factors disrupt and result in long-term changes in neuroinflammatory gene expression, sterol biosynthesis, and acylcarnitine levels in the b …
We were interested to assess if maternal immune activation (MIA), genetic interneuronal inhibition, and the combination of these two factors …
Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism‡.
Bidne KL, Rister AL, McCain AR, Hitt BD, Dodds ED, Wood JR. Bidne KL, et al. Biol Reprod. 2021 Jan 4;104(1):197-210. doi: 10.1093/biolre/ioaa191. Biol Reprod. 2021. PMID: 33048132 Free PMC article.
Dyslipidemia is a characteristic of maternal obesity and previous studies have demonstrated abnormalities in fatty acid oxidation and storage in term placentas. However, there is little information about the effect of pre-pregnancy obesity on placental lipid metabolism dur …
Dyslipidemia is a characteristic of maternal obesity and previous studies have demonstrated abnormalities in fatty acid oxidation and storag …
Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration.
Koul S, Schaal VL, Chand S, Pittenger ST, Nanoth Vellichirammal N, Kumar V, Guda C, Bevins RA, Yelamanchili SV, Pendyala G. Koul S, et al. Cells. 2020 Aug 11;9(8):1883. doi: 10.3390/cells9081883. Cells. 2020. PMID: 32796722 Free PMC article.
In summary, this study has identified sex-specific changes in BDEV biogenesis, protein cargo signatures, and molecular pathways associated with long-term nicotine self-administration....
In summary, this study has identified sex-specific changes in BDEV biogenesis, protein cargo signatures, and molecular pathways associated w …
Ultrasmall Mixed Eu-Gd Oxide Nanoparticles for Multimodal Fluorescence and Magnetic Resonance Imaging of Passive Accumulation and Retention in TBI.
Bony BA, Miller HA, Tarudji AW, Gee CC, Sarella A, Nichols MG, Kievit FM. Bony BA, et al. ACS Omega. 2020 Jun 23;5(26):16220-16227. doi: 10.1021/acsomega.0c01890. eCollection 2020 Jul 7. ACS Omega. 2020. PMID: 32656444 Free PMC article.
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI can have a long-term impact on the quality of life for survivors of all ages. However, there remains no approved treatment that improves outcomes following TBI, which is partially due to …
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI can have a long-term impact on the quality of …
Automated image analysis with ImageJ of yeast colony forming units from cannabis flowers.
Stolze N, Bader C, Henning C, Mastin J, Holmes AE, Sutlief AL. Stolze N, et al. J Microbiol Methods. 2019 Sep;164:105681. doi: 10.1016/j.mimet.2019.105681. Epub 2019 Aug 2. J Microbiol Methods. 2019. PMID: 31381981 Free PMC article.
The automated counting method could be used to quickly count numbers that are as high as 400 CFUs, reducing time of analysis with improved documentation because the images and the electronic colony counts can be saved on a computer or cloud for long term storage and data a …
The automated counting method could be used to quickly count numbers that are as high as 400 CFUs, reducing time of analysis with improved d …
Short term dynamics of the sputum microbiome among COPD patients.
Sinha R, Weissenburger-Moser LA, Clarke JL, Smith LM, Heires AJ, Romberger DJ, LeVan TD. Sinha R, et al. PLoS One. 2018 Mar 8;13(3):e0191499. doi: 10.1371/journal.pone.0191499. eCollection 2018. PLoS One. 2018. PMID: 29518088 Free PMC article.