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Page 1
Variability of Urinary Concentrations of Phenols, Parabens, and Triclocarban during Pregnancy in First Morning Voids and Pooled Samples.
Shin HM, Oh J, Kim K, Busgang SA, Barr DB, Panuwet P, Schmidt RJ, Hertz-Picciotto I, Bennett DH. Shin HM, et al. Environ Sci Technol. 2021 Dec 7;55(23):16001-16010. doi: 10.1021/acs.est.1c04140. Epub 2021 Nov 24. Environ Sci Technol. 2021. PMID: 34817155 Free PMC article.
However, because these compounds are quickly metabolized and excreted in urine, characterizing participants' long-term average exposure from a few spot samples is challenging. To examine the variability of urinary concentrations of these compounds during pregnancy, we quan …
However, because these compounds are quickly metabolized and excreted in urine, characterizing participants' long-term average exposu …
Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1.
Truong KM, Cherednichenko G, Pessah IN. Truong KM, et al. Toxicol Sci. 2019 Aug 1;170(2):509-524. doi: 10.1093/toxsci/kfz120. Toxicol Sci. 2019. PMID: 31127943 Free PMC article.
In conclusion, our study demonstrates DDx can directly interact and modulate RyR1 conformation, thereby altering SR Ca2+-dynamics and sensitize RyR1-expressing cells to RyR1 activators, which may ultimately contribute to long-term impairments in muscle health....
In conclusion, our study demonstrates DDx can directly interact and modulate RyR1 conformation, thereby altering SR Ca2+-dynamics and sensit …
Placental methylome analysis from a prospective autism study.
Schroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM. Schroeder DI, et al. Mol Autism. 2016 Dec 15;7:51. doi: 10.1186/s13229-016-0114-8. eCollection 2016. Mol Autism. 2016. PMID: 28018572 Free PMC article.
The placenta is a potentially useful surrogate tissue characterized by a methylation pattern of partially methylated domains (PMDs) and highly methylated domains (HMDs) reflective of methylation patterns observed in the early embryo. METHODS: In this study, we investigated human …
The placenta is a potentially useful surrogate tissue characterized by a methylation pattern of partially methylated domains (PMDs) and high …
Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation.
Rose DR, Careaga M, Van de Water J, McAllister K, Bauman MD, Ashwood P. Rose DR, et al. Brain Behav Immun. 2017 Jul;63:60-70. doi: 10.1016/j.bbi.2016.11.020. Epub 2016 Nov 19. Brain Behav Immun. 2017. PMID: 27876552 Free PMC article.
Self-directed behaviors were associated with T(H)2 cytokine production at year 4. Data from this study suggests long-term behavioral and immune activation was present in offspring following MIA. ...
Self-directed behaviors were associated with T(H)2 cytokine production at year 4. Data from this study suggests long-term behavioral …
Maternal immune activation leads to activated inflammatory macrophages in offspring.
Onore CE, Schwartzer JJ, Careaga M, Berman RF, Ashwood P. Onore CE, et al. Brain Behav Immun. 2014 May;38:220-6. doi: 10.1016/j.bbi.2014.02.007. Epub 2014 Feb 22. Brain Behav Immun. 2014. PMID: 24566386 Free PMC article.
Similar to changes in T cell function, we hypothesized that following MIA, offspring will have long-term changes in macrophage function. To test this theory, we utilized the poly (I:C) MIA mouse model in C57BL/6J mice and examined macrophage cytokine production in adult of …
Similar to changes in T cell function, we hypothesized that following MIA, offspring will have long-term changes in macrophage functi …
Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity.
Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN. Cao Z, et al. Mol Pharmacol. 2014 Apr;85(4):630-9. doi: 10.1124/mol.113.090076. Epub 2014 Jan 30. Mol Pharmacol. 2014. PMID: 24482397 Free PMC article.
Collectively these data identify a new mechanism by which bifenthrin potently alters Ca(2+) dynamics and Ca(2+)-dependent signaling in cortical neurons that have long term impacts on activity driven neuronal plasticity....
Collectively these data identify a new mechanism by which bifenthrin potently alters Ca(2+) dynamics and Ca(2+)-dependent signaling in corti …
Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism.
Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Walker CK, et al. Biol Psychiatry. 2013 Aug 1;74(3):204-11. doi: 10.1016/j.biopsych.2013.03.006. Epub 2013 Apr 25. Biol Psychiatry. 2013. PMID: 23623455 Free PMC article.
METHODS: Placentas were obtained from 117 births in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort of families who have one or more previous biological children with ASD, placing their newborn at elevated risk for neurodevelopmental compromise. Control …
METHODS: Placentas were obtained from 117 births in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort of families w …
Natural variability in bovine milk oligosaccharides from Danish Jersey and Holstein-Friesian breeds.
Sundekilde UK, Barile D, Meyrand M, Poulsen NA, Larsen LB, Lebrilla CB, German JB, Bertram HC. Sundekilde UK, et al. J Agric Food Chem. 2012 Jun 20;60(24):6188-96. doi: 10.1021/jf300015j. Epub 2012 Jun 6. J Agric Food Chem. 2012. PMID: 22632419 Free PMC article.
Jersey milk also possesses oligosaccharides with a higher degree of complexity and functional residues (fucose and sialic acid), suggesting it may therefore offer advantages in term of a wider array of bioactivities....
Jersey milk also possesses oligosaccharides with a higher degree of complexity and functional residues (fucose and sialic acid), suggesting …
Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants.
Wu YW, Croen LA, Torres AR, Van De Water J, Grether JK, Hsu NN. Wu YW, et al. Ann Neurol. 2009 Nov;66(5):663-70. doi: 10.1002/ana.21766. Ann Neurol. 2009. PMID: 19938160 Clinical Trial.
OBJECTIVE: Chorioamnionitis is associated with increased risk for cerebral palsy (CP) in term infants. A functional polymorphism in the interleukin-6 (IL-6) gene has been implicated in newborn brain injury. ...INTERPRETATION: Our data suggest that a functional polymorphism …
OBJECTIVE: Chorioamnionitis is associated with increased risk for cerebral palsy (CP) in term infants. A functional polymorphism in t …
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity.
Pessah IN, Cherednichenko G, Lein PJ. Pessah IN, et al. Pharmacol Ther. 2010 Feb;125(2):260-85. doi: 10.1016/j.pharmthera.2009.10.009. Epub 2009 Nov 25. Pharmacol Ther. 2010. PMID: 19931307 Free PMC article. Review.
The molecular and cellular mechanisms by which non-coplanar PCBs and related structures alter local and global Ca2+ signaling properties and the possible short and long-term consequences of these perturbations on neurodevelopment and neurodegeneration are reviewed....
The molecular and cellular mechanisms by which non-coplanar PCBs and related structures alter local and global Ca2+ signaling properties and …
14 results