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Small but Fierce: Tracking the Role of Extracellular Vesicles in Glioblastoma Progression and Therapeutic Resistance.
Schweiger MW, Tannous BA. Schweiger MW, et al. Adv Biosyst. 2020 Dec;4(12):e2000035. doi: 10.1002/adbi.202000035. Epub 2020 Sep 3. Adv Biosyst. 2020. PMID: 32881418 Free PMC article. Review.
Glioblastoma is the most common and aggressive brain tumor in adults. Most patients die within a year and long-term survival remains rare, owing to a combination of rapid progression/degeneration, lack of successful treatments, and high recurrence rates. ...
Glioblastoma is the most common and aggressive brain tumor in adults. Most patients die within a year and long-term survival remains …
Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-κB/STAT3 Signaling.
Schweiger MW, Li M, Giovanazzi A, Fleming RL, Tabet EI, Nakano I, Würdinger T, Chiocca EA, Tian T, Tannous BA. Schweiger MW, et al. Adv Biosyst. 2020 Dec;4(12):e1900312. doi: 10.1002/adbi.201900312. Epub 2020 Jun 9. Adv Biosyst. 2020. PMID: 32519463 Free PMC article.
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommon. GBM can be roughly divided into three different molecular subtypes, each varying in aggressiveness and treatment resistance. ...
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommo …
Liquid Biopsy Strategies to Distinguish Progression from Pseudoprogression and Radiation Necrosis in Glioblastomas.
Yekula A, Muralidharan K, Rosh ZS, Youngkin AE, Kang KM, Balaj L, Carter BS. Yekula A, et al. Adv Biosyst. 2020 Dec;4(12):e2000029. doi: 10.1002/adbi.202000029. Epub 2020 Jun 2. Adv Biosyst. 2020. PMID: 32484293 Free PMC article. Review.
At initial diagnosis, the majority of patients with central nervous system tumors undergo magnetic resonance imaging (MRI), followed by invasive brain biopsy to determine the molecular diagnosis of the WHO 2016 classification paradigm. Despite the importance of MRI for long-te …
At initial diagnosis, the majority of patients with central nervous system tumors undergo magnetic resonance imaging (MRI), followed by inva …
RNA delivery by extracellular vesicles in mammalian cells and its applications.
O'Brien K, Breyne K, Ughetto S, Laurent LC, Breakefield XO. O'Brien K, et al. Nat Rev Mol Cell Biol. 2020 Oct;21(10):585-606. doi: 10.1038/s41580-020-0251-y. Epub 2020 May 26. Nat Rev Mol Cell Biol. 2020. PMID: 32457507 Free PMC article. Review.
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of cellular origin that derive either from the endosomal compartment (exosomes) or as a result of shedding from the plasma membrane (microvesicles, oncosomes and apoptotic bodies). . …
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of cellular origin that derive either from …
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönit… See abstract for full author list ➔ Théry C, et al. J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018. J Extracell Vesicles. 2018. PMID: 30637094 Free PMC article.
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, mic …
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of ex …
Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma.
Speranza MC, Passaro C, Ricklefs F, Kasai K, Klein SR, Nakashima H, Kaufmann JK, Ahmed AK, Nowicki MO, Obi P, Bronisz A, Aguilar-Cordova E, Aguilar LK, Guzik BW, Breakefield X, Weissleder R, Freeman GJ, Reardon DA, Wen PY, Chiocca EA, Lawler SE. Speranza MC, et al. Neuro Oncol. 2018 Jan 22;20(2):225-235. doi: 10.1093/neuonc/nox139. Neuro Oncol. 2018. PMID: 29016938 Free PMC article.
Both GMCI and anti-PD-1 increased intratumoral T-cell infiltration. A higher percentage of long-term survivors was observed in mice treated with combined GMCI/anti-PD-1 relative to single treatments. Long-term survivors were protected from tumor rechallenge, demonst …
Both GMCI and anti-PD-1 increased intratumoral T-cell infiltration. A higher percentage of long-term survivors was observed in mice t …
Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture.
Zhang X, Abels ER, Redzic JS, Margulis J, Finkbeiner S, Breakefield XO. Zhang X, et al. Cell Mol Neurobiol. 2016 Apr;36(3):459-70. doi: 10.1007/s10571-016-0350-7. Epub 2016 Mar 7. Cell Mol Neurobiol. 2016. PMID: 26951563 Free PMC article.
These findings support the potential of EVs to deliver toxic expanded trinucleotide repeat RNAs from one cell to another, but further work will be needed to evaluate potential EV and cell-type specificity of transfer and effects of long-term exposure. It seems likely that …
These findings support the potential of EVs to deliver toxic expanded trinucleotide repeat RNAs from one cell to another, but further work w …
Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.
Jun HJ, Bronson RT, Charest A. Jun HJ, et al. Stem Cells. 2014 Feb;32(2):338-48. doi: 10.1002/stem.1554. Stem Cells. 2014. PMID: 24115218 Free PMC article.
The MET-positive cells displayed clonogenic potential and long-term self-renewal ability in vitro and are capable of differentiating into multiple lineages. ...
The MET-positive cells displayed clonogenic potential and long-term self-renewal ability in vitro and are capable of differentiating …
HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part II. Vector systems and applications.
Jacobs A, Breakefield XO, Fraefel C. Jacobs A, et al. Neoplasia. 1999 Nov;1(5):402-16. doi: 10.1038/sj.neo.7900056. Neoplasia. 1999. PMID: 10933055 Free PMC article. Review.
Helper virus-free HSV/AAV hybrid amplicon vectors have great promise in mediating long-term gene expression in the PNS and CNS for the treatment of various neurodegenerative disorders or chronic pain. ...
Helper virus-free HSV/AAV hybrid amplicon vectors have great promise in mediating long-term gene expression in the PNS and CNS for th …
Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons.
Sena-Esteves M, Saeki Y, Camp SM, Chiocca EA, Breakefield XO. Sena-Esteves M, et al. J Virol. 1999 Dec;73(12):10426-39. doi: 10.1128/JVI.73.12.10426-10439.1999. J Virol. 1999. PMID: 10559361 Free PMC article.
Infection of human and dog primary gliomas with this system resulted in the production of retrovirus vectors for more than 1 week and the long-term retention and increase in transgene activity over time in these cell populations. ...
Infection of human and dog primary gliomas with this system resulted in the production of retrovirus vectors for more than 1 week and the lo …