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Rapamycin treatment improves neuron viability in an in vitro model of stroke.
Fletcher L, Evans TM, Watts LT, Jimenez DF, Digicaylioglu M. Fletcher L, et al. PLoS One. 2013 Jul 4;8(7):e68281. doi: 10.1371/journal.pone.0068281. Print 2013. PLoS One. 2013. PMID: 23861877 Free PMC article.
Ischemic stroke is the leading cause of serious, long-term adult disability and is associated with sensorimotor and cognitive impairments due to neuronal degeneration. ...
Ischemic stroke is the leading cause of serious, long-term adult disability and is associated with sensorimotor and cognitive impairm …
Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals.
Chavez AO, Kamath S, Jani R, Sharma LK, Monroy A, Abdul-Ghani MA, Centonze VE, Sathyanarayana P, Coletta DK, Jenkinson CP, Bai Y, Folli F, Defronzo RA, Tripathy D. Chavez AO, et al. J Clin Endocrinol Metab. 2010 Jan;95(1):422-9. doi: 10.1210/jc.2009-1387. Epub 2009 Oct 28. J Clin Endocrinol Metab. 2010. PMID: 19864449 Free PMC article. Clinical Trial.
No significant changes in genes expression, citrate synthase activity, and total ATP content were observed after either lipid or saline infusion. CONCLUSIONS: Short-term physiological increase in plasma FFA concentration in lean normal glucose tolerant subjects induces ins …
No significant changes in genes expression, citrate synthase activity, and total ATP content were observed after either lipid or saline infu …
The in vivo gene expression signature of oxidative stress.
Han ES, Muller FL, Pérez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A. Han ES, et al. Physiol Genomics. 2008 Jun 12;34(1):112-26. doi: 10.1152/physiolgenomics.00239.2007. Epub 2008 Apr 29. Physiol Genomics. 2008. PMID: 18445702 Free PMC article.
The expression response to elevated oxidative stress in vivo does not involve an upregulation of classic antioxidant genes, although long-term oxidative stress in Sod1(-/-) mice leads to a significant upregulation of thiol antioxidants (e.g., Mt1, Srxn1, Gclc, Txnrd1), whi …
The expression response to elevated oxidative stress in vivo does not involve an upregulation of classic antioxidant genes, although long- …