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Telomerase inhibitor Imetelstat (GRN163L) limits the lifespan of human pancreatic cancer cells.
Burchett KM, Yan Y, Ouellette MM. Burchett KM, et al. Among authors: ouellette mm. PLoS One. 2014 Jan 7;9(1):e85155. doi: 10.1371/journal.pone.0085155. eCollection 2014. PLoS One. 2014. PMID: 24409321 Free PMC article.
GRN163L (Imetelstat) is a lipid-conjugated N3'P5' thio-phosphoramidate oligonucleotide that blocks the template region of telomerase. The aim of this study was to define the effects of long-term GRN163L exposure on the maintenance of telomeres and lifespan of pancreatic ca …
GRN163L (Imetelstat) is a lipid-conjugated N3'P5' thio-phosphoramidate oligonucleotide that blocks the template region of telomerase. The ai …
Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation.
Momi N, Ponnusamy MP, Kaur S, Rachagani S, Kunigal SS, Chellappan S, Ouellette MM, Batra SK. Momi N, et al. Among authors: ouellette mm. Oncogene. 2013 Mar 14;32(11):1384-95. doi: 10.1038/onc.2012.163. Epub 2012 May 21. Oncogene. 2013. PMID: 22614008 Free PMC article.
Despite evidence that long-term smoking is the leading risk factor for pancreatic malignancies, the underlying mechanism(s) for cigarette-smoke (CS)-induced pancreatic cancer (PC) pathogenesis has not been well established. ...
Despite evidence that long-term smoking is the leading risk factor for pancreatic malignancies, the underlying mechanism(s) for cigar …
Gene targeting in adult rhesus macaque fibroblasts.
Meehan DT, Zink MA, Mahlen M, Nelson M, Sanger WG, Mitalipov SM, Wolf DP, Ouellette MM, Norgren RB Jr. Meehan DT, et al. Among authors: ouellette mm. BMC Biotechnol. 2008 Mar 26;8:31. doi: 10.1186/1472-6750-8-31. BMC Biotechnol. 2008. PMID: 18366794 Free PMC article.
RESULTS: A primary culture of adult male fibroblasts was transfected with hTERT to overcome senescence and allow long term in vitro manipulations. Successful gene targeting of the HPRT locus in rhesus macaques was achieved by electroporating S-phase synchronized cells with …
RESULTS: A primary culture of adult male fibroblasts was transfected with hTERT to overcome senescence and allow long term in vitro m …
Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells.
Salaria SN, Illei P, Sharma R, Walter KM, Klein AP, Eshleman JR, Maitra A, Schulick R, Winter J, Ouellette MM, Goggins M, Hruban R. Salaria SN, et al. Among authors: ouellette mm. Cancer Biol Ther. 2007 Mar;6(3):324-8. doi: 10.4161/cbt.6.3.3904. Epub 2007 Mar 24. Cancer Biol Ther. 2007. PMID: 17404500 Free PMC article.
Western blot analysis was used to determine the epitope(s) of palladin recognized by the antibody as well as the relative levels of palladin expression in short-term cultures of stromal fibroblasts, non-neoplastic ductal cells and pancreatic cancer cell lines. ...
Western blot analysis was used to determine the epitope(s) of palladin recognized by the antibody as well as the relative levels of palladin …
High-intensity resistance training improves muscle strength, self-reported function, and disability in long-term stroke survivors.
Ouellette MM, LeBrasseur NK, Bean JF, Phillips E, Stein J, Frontera WR, Fielding RA. Ouellette MM, et al. Stroke. 2004 Jun;35(6):1404-9. doi: 10.1161/01.STR.0000127785.73065.34. Epub 2004 Apr 22. Stroke. 2004. PMID: 15105515 Clinical Trial.
BACKGROUND AND PURPOSE: To evaluate the efficacy of supervised high-intensity progressive resistance training (PRT) on lower extremity strength, function, and disability in older, long-term stroke survivors. METHODS: Forty-two volunteers aged 50 years and above, 6 months t …
BACKGROUND AND PURPOSE: To evaluate the efficacy of supervised high-intensity progressive resistance training (PRT) on lower extremity stren …
Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase.
Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE, Liss HS, Shay JW, Wright WE. Ouellette MM, et al. J Biol Chem. 2000 Apr 7;275(14):10072-6. doi: 10.1074/jbc.275.14.10072. J Biol Chem. 2000. PMID: 10744686 Free article.
Human fibroblasts expressing the catalytic component of human telomerase (hTERT) have been followed for 250-400 population doublings. As expected, telomerase activity declined in long term culture of stable transfectants. Surprisingly, however, clones with average telomere …
Human fibroblasts expressing the catalytic component of human telomerase (hTERT) have been followed for 250-400 population doublings. As exp …