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An Early Myelosuppression in the Acute Mouse Sepsis Is Partly Outcome-Dependent.
Skirecki T, Drechsler S, Jeznach A, Hoser G, Jafarmadar M, Kawiak J, Osuchowski MF. Skirecki T, et al. Among authors: osuchowski mf. Front Immunol. 2021 Jul 22;12:708670. doi: 10.3389/fimmu.2021.708670. eCollection 2021. Front Immunol. 2021. PMID: 34367170 Free PMC article.
CLP strongly reduced the common myeloid and multipotent progenitors, short- and long-term hematopoietic stem cell (HSC) counts in the bone marrow; lineage(-)ckit(+)Sca-1(+) and short-term HSC suppression was greater in P-DIE versus P-SUR mice. ...
CLP strongly reduced the common myeloid and multipotent progenitors, short- and long-term hematopoietic stem cell (HSC) counts in the …
Current gaps in sepsis immunology: new opportunities for translational research.
Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G, La Rosée P, Monneret G, Venet F, Bauer M, Brunkhorst FM, Kox M, Cavaillon JM, Uhle F, Weigand MA, Flohé SB, Wiersinga WJ, Martin-Fernandez M, Almansa R, Martin-Loeches I, Torres A, Giamarellos-Bourboulis EJ, Girardis M, Cossarizza A, Netea MG, van der Poll T, Scherag A, Meisel C, Schefold JC, Bermejo-Martín JF. Rubio I, et al. Among authors: osuchowski mf. Lancet Infect Dis. 2019 Dec;19(12):e422-e436. doi: 10.1016/S1473-3099(19)30567-5. Epub 2019 Oct 17. Lancet Infect Dis. 2019. PMID: 31630991 Review.
The European Group on Immunology of Sepsis has identified major gaps that should be addressed with high priority, such as understanding how immunological alterations predispose to sepsis, key aspects of the immunopathological events during sepsis, and the long-term consequ …
The European Group on Immunology of Sepsis has identified major gaps that should be addressed with high priority, such as understanding how …
Delayed activation of PPAR-beta/delta improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation.
Busch D, Kapoor A, Rademann P, Hildebrand F, Bahrami S, Thiemermann C, Osuchowski MF. Busch D, et al. Among authors: osuchowski mf. Innate Immun. 2018 May;24(4):262-273. doi: 10.1177/1753425918771748. Epub 2018 Apr 26. Innate Immun. 2018. PMID: 29697010 Free PMC article.
We hypothesized that the PPAR-beta/delta-agonist GW0742 improves long-term outcome after sepsis caused by cecal ligation and puncture (CLP). ...CLP mice treated with GW0742 exhibited a similar increase in most of the biochemical markers of organ injury/dysfunction (lactate …
We hypothesized that the PPAR-beta/delta-agonist GW0742 improves long-term outcome after sepsis caused by cecal ligation and puncture …
Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis.
Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Röstel F, Kaszaki J, Szabo A, Skulachev VP, Bauer M, Bahrami S, Weis S, Kozlov AV, Osuchowski MF. Rademann P, et al. Among authors: osuchowski mf. Oxid Med Cell Longev. 2017;2017:6412682. doi: 10.1155/2017/6412682. Epub 2017 Sep 19. Oxid Med Cell Longev. 2017. PMID: 29104729 Free PMC article.
We investigated whether two mitochondria-targeted antioxidants (mtAOX; SkQ1 and MitoTEMPO) improved long-term outcome, lessened inflammation, and improved organ homeostasis in polymicrobial murine sepsis. 3-month-old female CD-1 mice (n = 90) underwent cecal ligation and p …
We investigated whether two mitochondria-targeted antioxidants (mtAOX; SkQ1 and MitoTEMPO) improved long-term outcome, lessened infla …
Noninvasive model of sciatic nerve conduction in healthy and septic mice: reliability and normative data.
Osuchowski MF, Teener J, Remick D. Osuchowski MF, et al. Muscle Nerve. 2009 Oct;40(4):610-6. doi: 10.1002/mus.21284. Muscle Nerve. 2009. PMID: 19618431 Free PMC article.
Our sedated and awake NCS system enabled minimally invasive long-term repeated measurements. The mean compound muscle action potential (CMAP) amplitude and latency were 17.4 mV and 1.11 ms, respectively (n = 59). ...This study provides a new tool for the assessment of peri …
Our sedated and awake NCS system enabled minimally invasive long-term repeated measurements. The mean compound muscle action potentia …