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Year Number of Results
1997 1
2000 2
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2004 2
2005 1
2006 1
2009 2
2011 2
2012 1
2015 2
2016 1
2018 1
2019 3
2020 4
2021 4
2022 2
2024 1

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31 results

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Page 1
Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.
Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, McLaughlin VV, Peacock AJ, Simonneau G, Vachiery JL, Grünig E, Oudiz RJ, Vonk-Noordegraaf A, White RJ, Blair C, Gillies H, Miller KL, Harris JH, Langley J, Rubin LJ; AMBITION Investigators. Galiè N, et al. N Engl J Med. 2015 Aug 27;373(9):834-44. doi: 10.1056/NEJMoa1413687. N Engl J Med. 2015. PMID: 26308684 Free article. Clinical Trial.
BACKGROUND: Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce. ...The primary end point in a time-to-event analysis was the first event of clinical failure, whi …
BACKGROUND: Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with p …
Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry.
Hoeper MM, Pausch C, Grünig E, Klose H, Staehler G, Huscher D, Pittrow D, Olsson KM, Vizza CD, Gall H, Benjamin N, Distler O, Opitz C, Gibbs JSR, Delcroix M, Ghofrani HA, Rosenkranz S, Ewert R, Kaemmerer H, Lange TJ, Kabitz HJ, Skowasch D, Skride A, Jureviciene E, Paleviciute E, Miliauskas S, Claussen M, Behr J, Milger K, Halank M, Wilkens H, Wirtz H, Pfeuffer-Jovic E, Harbaum L, Scholtz W, Dumitrescu D, Bruch L, Coghlan G, Neurohr C, Tsangaris I, Gorenflo M, Scelsi L, Vonk-Noordegraaf A, Ulrich S, Held M. Hoeper MM, et al. Among authors: opitz c. J Heart Lung Transplant. 2020 Dec;39(12):1435-1444. doi: 10.1016/j.healun.2020.09.011. Epub 2020 Sep 30. J Heart Lung Transplant. 2020. PMID: 33082079 Free article.
The term idiopathic pulmonary arterial hypertension (IPAH) is used to categorize patients with pre-capillary pulmonary hypertension of unknown origin. ...
The term idiopathic pulmonary arterial hypertension (IPAH) is used to categorize patients with pre-capillary pulmonary hypertension o …
COMPERA 2.0: a refined four-stratum risk assessment model for pulmonary arterial hypertension.
Hoeper MM, Pausch C, Olsson KM, Huscher D, Pittrow D, Grünig E, Staehler G, Vizza CD, Gall H, Distler O, Opitz C, Gibbs JSR, Delcroix M, Ghofrani HA, Park DH, Ewert R, Kaemmerer H, Kabitz HJ, Skowasch D, Behr J, Milger K, Halank M, Wilkens H, Seyfarth HJ, Held M, Dumitrescu D, Tsangaris I, Vonk-Noordegraaf A, Ulrich S, Klose H, Claussen M, Lange TJ, Rosenkranz S. Hoeper MM, et al. Among authors: opitz c. Eur Respir J. 2022 Jul 7;60(1):2102311. doi: 10.1183/13993003.02311-2021. Print 2022 Jul. Eur Respir J. 2022. PMID: 34737226 Free PMC article.
The refined four-stratum risk model yielded a more nuanced separation and predicted long-term survival, especially at follow-up assessment. Changes in risk from baseline to follow-up were observed in 31.1% of the patients with the three-stratum model and in 49.2% with the …
The refined four-stratum risk model yielded a more nuanced separation and predicted long-term survival, especially at follow-up asses …
Treatment strategies and survival of patients with connective tissue disease and pulmonary arterial hypertension: a COMPERA analysis.
Distler O, Ofner C, Huscher D, Jordan S, Ulrich S, Stähler G, Grünig E, Held M, Ghofrani HA, Claussen M, Lange TJ, Klose H, Rosenkranz S, Vonk-Noordegraaf A, Vizza CD, Delcroix M, Opitz C, Pausch C, Scelsi L, Neurohr C, Olsson KM, Coghlan JG, Halank M, Skowasch D, Behr J, Milger K, Remppis BA, Skride A, Jureviciene E, Gumbiene L, Miliauskas S, Löffler-Ragg J, Wilkens H, Pittrow D, Hoeper MM, Ewert R. Distler O, et al. Among authors: opitz c. Rheumatology (Oxford). 2024 Apr 2;63(4):1139-1146. doi: 10.1093/rheumatology/kead360. Rheumatology (Oxford). 2024. PMID: 37462520 Free PMC article.
However, for patients with SSc-PAH, our results suggest that long-term survival may be improved with initial ERA-PDE5i combination therapy compared with initial monotherapy....
However, for patients with SSc-PAH, our results suggest that long-term survival may be improved with initial ERA-PDE5i combination th …
[Pulmonary hypertension in left heart disease].
Opitz CF, Gläser S, Ewert R. Opitz CF, et al. Dtsch Med Wochenschr. 2009 Aug;134 Suppl 5:S167-9. doi: 10.1055/s-0029-1225316. Epub 2009 Aug 28. Dtsch Med Wochenschr. 2009. PMID: 19718607 Review. German.
Pulmonary hypertension (PH) is a relatively common hemodynamic finding in patients with left-sided heart disease and is usually associated with increased morbidity and mortality. However, so far no study has demonstrated long-term benefit from drugs specifically designed t …
Pulmonary hypertension (PH) is a relatively common hemodynamic finding in patients with left-sided heart disease and is usually associated w …
Intravenous prostacyclin-analogue therapy in pulmonary arterial hypertension - A review of the past, present and future.
Stubbe B, Opitz CF, Halank M, Habedank D, Ewert R. Stubbe B, et al. Among authors: opitz cf. Respir Med. 2021 Apr;179:106336. doi: 10.1016/j.rmed.2021.106336. Epub 2021 Feb 16. Respir Med. 2021. PMID: 33647836 Free article. Review.
Epoprostenol, iloprost and treprostinil have all been used intravenously in PAH, but titration, dosing and dose escalation in long-term therapy are not standardized. Intravenous prostacyclin analogues are still under-used, despite available data suggesting that early and b …
Epoprostenol, iloprost and treprostinil have all been used intravenously in PAH, but titration, dosing and dose escalation in long-term …
Functional interactions between B lymphocytes and the innate immune system.
Lampropoulou V, Shen P, Hilgenberg E, Ries S, Opitz C, Fillatreau S. Lampropoulou V, et al. Among authors: opitz c. Infect Disord Drug Targets. 2012 Jun;12(3):191-9. doi: 10.2174/187152612800564374. Infect Disord Drug Targets. 2012. PMID: 22394177 Review.
However, recent studies highlighted important roles for innate cells in initial presentation of antigen to B cells after immunization, and in long-term maintenance of antibody-producing cells in bone marrow after resolution of immune responses. ...
However, recent studies highlighted important roles for innate cells in initial presentation of antigen to B cells after immunization, and i …
Temporal trends in pulmonary arterial hypertension: results from the COMPERA registry.
Hoeper MM, Pausch C, Grünig E, Staehler G, Huscher D, Pittrow D, Olsson KM, Vizza CD, Gall H, Distler O, Opitz C, Gibbs JSR, Delcroix M, Ghofrani HA, Rosenkranz S, Park DH, Ewert R, Kaemmerer H, Lange TJ, Kabitz HJ, Skowasch D, Skride A, Claussen M, Behr J, Milger K, Halank M, Wilkens H, Seyfarth HJ, Held M, Dumitrescu D, Tsangaris I, Vonk-Noordegraaf A, Ulrich S, Klose H. Hoeper MM, et al. Among authors: opitz c. Eur Respir J. 2022 Jun 2;59(6):2102024. doi: 10.1183/13993003.02024-2021. Print 2022 Jun. Eur Respir J. 2022. PMID: 34675047 Free PMC article.
However, it is unclear to what extent this treatment strategy is adopted in clinical practice and if it is associated with improved long-term survival. METHODS: We analysed data from COMPERA, a large European pulmonary hypertension registry, to assess temporal trends in th …
However, it is unclear to what extent this treatment strategy is adopted in clinical practice and if it is associated with improved long- …
Long-term safety and outcome of intravenous treprostinil via an implanted pump in pulmonary hypertension.
Richter MJ, Harutyunova S, Bollmann T, Classen S, Gall H, Gerhardt Md F, Grimminger F, Grimminger J, Grünig E, Guth S, Halank M, Heine A, Hoeper MM, Klose H, Lange TJ, Meyer K, Neurohr C, Nickolaus K, Olsson KM, Opitz CF, Rosenkranz S, Seyfarth HJ, Warnke C, Wiedenroth C, Ghofrani HA, Ewert R. Richter MJ, et al. Among authors: opitz cf. J Heart Lung Transplant. 2018 Oct;37(10):1235-1244. doi: 10.1016/j.healun.2018.06.006. Epub 2018 Jun 21. J Heart Lung Transplant. 2018. PMID: 30293617
BACKGROUND: We examined safety and long-term outcomes of intravenous treprostinil administered via the implantable LENUS Pro pump in patients with severe pulmonary hypertension (PH). METHODS: Patients with PH undergoing pump implantation between December 2009 and October 2 …
BACKGROUND: We examined safety and long-term outcomes of intravenous treprostinil administered via the implantable LENUS Pro pump in …
Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes.
Kessler T, Berberich A, Sadik A, Sahm F, Gorlia T, Meisner C, Hoffmann DC, Wick A, Kickingereder P, Rübmann P, Bendszus M, Opitz C, Weller M, van den Bent M, Stupp R, Winkler F, Brandes A, von Deimling A, Platten M, Wick W. Kessler T, et al. Among authors: opitz c. Cancer Med. 2020 Nov;9(22):8373-8385. doi: 10.1002/cam4.3447. Epub 2020 Sep 29. Cancer Med. 2020. PMID: 32991787 Free PMC article.
Primary glioma cells show methylation patterns that resemble RTK I and II glioblastoma and long term established glioma cell lines do not match with glioblastoma subtypes. ...
Primary glioma cells show methylation patterns that resemble RTK I and II glioblastoma and long term established glioma cell lines do …
31 results