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Copper: from neurotransmission to neuroproteostasis.
Opazo CM, Greenough MA, Bush AI. Opazo CM, et al. Front Aging Neurosci. 2014 Jul 3;6:143. doi: 10.3389/fnagi.2014.00143. eCollection 2014. Front Aging Neurosci. 2014. PMID: 25071552 Free PMC article. Review.
In particular, different studies have shown the effect of copper at brain synapses, where it inhibits Long Term Potentation (LTP) and receptor pharmacology. Paradoxically, according to recent studies copper is required for a normal LTP response. ...
In particular, different studies have shown the effect of copper at brain synapses, where it inhibits Long Term Potentation (LTP) and …
Ibuprofen inhibits the synaptic failure induced by the amyloid-β peptide in hippocampal neurons.
Zurita MP, Muñoz G, Sepúlveda FJ, Gómez P, Castillo C, Burgos CF, Fuentealba J, Opazo C, Aguayo LG. Zurita MP, et al. Among authors: opazo c. J Alzheimers Dis. 2013;35(3):463-73. doi: 10.3233/JAD-122314. J Alzheimers Dis. 2013. PMID: 23455989
Nevertheless, it has been proposed that NSAIDs exert part of their effects by reducing long-term cerebral neuroinflammation, although this mechanism has not been proven. ...
Nevertheless, it has been proposed that NSAIDs exert part of their effects by reducing long-term cerebral neuroinflammation, although …
Biphasic effects of copper on neurotransmission in rat hippocampal neurons.
Peters C, Muñoz B, Sepúlveda FJ, Urrutia J, Quiroz M, Luza S, De Ferrari GV, Aguayo LG, Opazo C. Peters C, et al. Among authors: opazo c. J Neurochem. 2011 Oct;119(1):78-88. doi: 10.1111/j.1471-4159.2011.07417.x. Epub 2011 Sep 1. J Neurochem. 2011. PMID: 21824141 Free article.
We also found that copper-treated neurons displayed an undistinguishable neurotransmission to control neurons after 24 h of treatment, indicating that changes in neurotransmission induced by copper at 3 h of incubation are homeostatically regulated after long-term exposure …
We also found that copper-treated neurons displayed an undistinguishable neurotransmission to control neurons after 24 h of treatment, indic …