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Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program.
Azizi M, Sharp ASP, Fisher NDL, Weber MA, Lobo MD, Daemen J, Lurz P, Mahfoud F, Schmieder RE, Basile J, Bloch MJ, Saxena M, Wang Y, Sanghvi K, Jenkins JS, Devireddy C, Rader F, Gosse P, Claude L, Augustin DA, McClure CK, Kirtane AJ; RADIANCE Investigators. Azizi M, et al. Circulation. 2024 Mar 5;149(10):747-759. doi: 10.1161/CIRCULATIONAHA.123.066941. Epub 2023 Oct 26. Circulation. 2024. PMID: 37883784 Clinical Trial.
BACKGROUND: The randomized, sham-controlled RADIANCE-HTN (A Study of the Recor Medical Paradise System in Clinical Hypertension) SOLO, RADIANCE-HTN TRIO, and RADIANCE II (A Study of the Recor Medical Paradise System in Stage II Hypertension) trials independently met their primary …
BACKGROUND: The randomized, sham-controlled RADIANCE-HTN (A Study of the Recor Medical Paradise System in Clinical Hypertension) SOLO, RADIA …
Effect of Intensive Blood Pressure Control on Kidney Outcomes: Long-Term Electronic Health Record-Based Post-Trial Follow-Up of SPRINT.
Drawz PE, Lenoir KM, Rai NK, Rastogi A, Chu CD, Rahbari-Oskoui FF, Whelton PK, Thomas G, McWilliams A, Agarwal AK, Suarez MM, Dobre M, Powell J, Rocco MV, Lash JP, Oparil S, Raj DS, Dwyer JP, Rahman M, Soman S, Townsend RR, Pemu P, Horwitz E, Ix JH, Tuot DS, Ishani A, Pajewski NM. Drawz PE, et al. Among authors: oparil s. Clin J Am Soc Nephrol. 2023 Oct 25;19(2):213-23. doi: 10.2215/CJN.0000000000000335. Online ahead of print. Clin J Am Soc Nephrol. 2023. PMID: 37883184
BACKGROUND: Intensive BP lowering in the Systolic Blood Pressure Intervention Trial (SPRINT) produced acute decreases in kidney function and higher risk for AKI. We evaluated the effect of intensive BP lowering on long-term changes in kidney function using trial and outpat …
BACKGROUND: Intensive BP lowering in the Systolic Blood Pressure Intervention Trial (SPRINT) produced acute decreases in kidney function and …
Breastfeeding initiation and duration among people with mild chronic hypertension: a secondary analysis of the Chronic Hypertension and Pregnancy trial.
Goulding AN, Antoniewicz L, Leach JM, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes BL, Bell J, Edwards RK, Gibson K, Haas DM, Plante L, Metz TD, Casey B, Esplin S, Longo S, Hoffman M, Saade GR, Hoppe KK, Foroutan J, Tuuli M, Owens MY, Simhan HN, Frey H, Rosen T, Palatnik A, Baker S, Reddy UM, Kinzler W, Su E, Krishna I, Nguyen N, Norton ME, Skupski D, El-Sayed YY, Ogunyemi D, Harper LM, Ambalavanan N, Oparil S, Szychowski JM, Tita AT; Chronic Hypertension and Pregnancy Trial Consortium. Goulding AN, et al. Among authors: oparil s. Am J Obstet Gynecol MFM. 2023 Sep;5(9):101086. doi: 10.1016/j.ajogmf.2023.101086. Epub 2023 Jul 10. Am J Obstet Gynecol MFM. 2023. PMID: 37437694 Clinical Trial.
OBJECTIVE: This study aimed to evaluate whether breastfeeding initiation and short-term duration assessed at the postpartum clinic visit differed according to perinatal blood pressure treatment strategy (targeting blood pressure <140/90 mm Hg vs reserving antihypertensi …
OBJECTIVE: This study aimed to evaluate whether breastfeeding initiation and short-term duration assessed at the postpartum clinic vi …
Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control: A Secondary Analysis of a Randomized Clinical Trial.
Jaeger BC, Bress AP, Bundy JD, Cheung AK, Cushman WC, Drawz PE, Johnson KC, Lewis CE, Oparil S, Rocco MV, Rapp SR, Supiano MA, Whelton PK, Williamson JD, Wright JT Jr, Reboussin DM, Pajewski NM. Jaeger BC, et al. Among authors: oparil s. JAMA Cardiol. 2022 Nov 1;7(11):1138-1146. doi: 10.1001/jamacardio.2022.3345. JAMA Cardiol. 2022. PMID: 36223105 Free PMC article.
However, the legacy effect of intensive treatment is unknown. OBJECTIVE: To evaluate the long-term effects of randomization to intensive treatment with the incidence of cardiovascular and all-cause mortality approximately 4.5 years after the trial ended. ...Given increasin …
However, the legacy effect of intensive treatment is unknown. OBJECTIVE: To evaluate the long-term effects of randomization to intens …
Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial.
Bhatt DL, Vaduganathan M, Kandzari DE, Leon MB, Rocha-Singh K, Townsend RR, Katzen BT, Oparil S, Brar S, DeBruin V, Fahy M, Bakris GL; SYMPLICITY HTN-3 Steering Committee Investigators. Bhatt DL, et al. Among authors: oparil s. Lancet. 2022 Oct 22;400(10361):1405-1416. doi: 10.1016/S0140-6736(22)01787-1. Epub 2022 Sep 18. Lancet. 2022. PMID: 36130612 Clinical Trial.
For comparisons between the renal artery denervation and sham control groups, follow-up blood pressure values were imputed for patients in the crossover group using their most recent pre-crossover masked blood pressure value. We report long-term blood pressure changes in r …
For comparisons between the renal artery denervation and sham control groups, follow-up blood pressure values were imputed for patients in t …
Integrated Care Model of Adiposity-Related Chronic Diseases.
Le Jemtel TH, Samson R, Oparil S. Le Jemtel TH, et al. Among authors: oparil s. Curr Hypertens Rep. 2022 Nov;24(11):563-570. doi: 10.1007/s11906-022-01223-3. Epub 2022 Sep 9. Curr Hypertens Rep. 2022. PMID: 36083439 Review.
PURPOSE OF REVIEW: Although obesity is a disease, most patients with obesity do not undergo effective treatment nor adhere to long-term care. We examine the barriers that patients with obesity confront when searching for effective treatment and propose an integrated care m …
PURPOSE OF REVIEW: Although obesity is a disease, most patients with obesity do not undergo effective treatment nor adhere to long-term …
Effect of Intensive versus Standard BP Control on AKI and Subsequent Cardiovascular Outcomes and Mortality: Findings from the SPRINT EHR Study.
Drawz PE, Rai NK, Lenoir KM, Suarez M, Powell JR, Raj DS, Beddhu S, Agarwal AK, Soman S, Whelton PK, Lash J, Rahbari-Oskoui FF, Dobre M, Parkulo MA, Rocco MV, McWilliams A, Dwyer JP, Thomas G, Rahman M, Oparil S, Horwitz E, Pajewski NM, Ishani A. Drawz PE, et al. Among authors: oparil s. Kidney360. 2022 May 10;3(7):1253-1262. doi: 10.34067/KID.0001572022. eCollection 2022 Jul 28. Kidney360. 2022. PMID: 35919535 Free PMC article.
An Update on Refractory Hypertension.
Matanes F, Khan MB, Siddiqui M, Dudenbostel T, Calhoun D, Oparil S. Matanes F, et al. Among authors: oparil s. Curr Hypertens Rep. 2022 Jul;24(7):225-234. doi: 10.1007/s11906-022-01185-6. Epub 2022 Apr 6. Curr Hypertens Rep. 2022. PMID: 35384577 Free PMC article. Review.
Sustained SBP control and long-term nursing home admission among Medicare beneficiaries.
Bowling CB, Sloane R, Pieper C, Luciano A, Davis BR, Simpson LM, Einhorn PT, Oparil S, Muntner P. Bowling CB, et al. Among authors: oparil s. J Hypertens. 2021 Nov 1;39(11):2258-2264. doi: 10.1097/HJH.0000000000002926. J Hypertens. 2021. PMID: 34232161 Free PMC article. Clinical Trial.
Nursing home admissions were identified using the Medicare Long Term Care Minimum Data Set. RESULTS: The mean age of participants was 73.8 years and 44.3% were men. ...CONCLUSION: Among Medicare beneficiaries in ALLHAT, sustained SBP control was associated with a lower ris …
Nursing home admissions were identified using the Medicare Long Term Care Minimum Data Set. RESULTS: The mean age of participants was …
Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial.
Azizi M, Sanghvi K, Saxena M, Gosse P, Reilly JP, Levy T, Rump LC, Persu A, Basile J, Bloch MJ, Daemen J, Lobo MD, Mahfoud F, Schmieder RE, Sharp ASP, Weber MA, Sapoval M, Fong P, Pathak A, Lantelme P, Hsi D, Bangalore S, Witkowski A, Weil J, Kably B, Barman NC, Reeve-Stoffer H, Coleman L, McClure CK, Kirtane AJ; RADIANCE-HTN investigators. Azizi M, et al. Lancet. 2021 Jun 26;397(10293):2476-2486. doi: 10.1016/S0140-6736(21)00788-1. Epub 2021 May 16. Lancet. 2021. PMID: 34010611 Clinical Trial.
If the blood pressure lowering effect and safety of renal denervation are maintained in the long term, renal denervation might be an alternative to the addition of further antihypertensive medications in patients with resistant hypertension. ...
If the blood pressure lowering effect and safety of renal denervation are maintained in the long term, renal denervation might be an …
55 results