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2002 1
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2013 1
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2017 2
2021 1
2024 0

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Page 1
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. Singer M, et al. Among authors: opal sm. JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. JAMA. 2016. PMID: 26903338 Free PMC article.
Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to discrepancies in reported incidence and observed mortality. The task force concluded the term severe sepsis was redundant. RECOMMENDATIONS: Sepsis should …
Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to discrepancies in rep …
Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Hotchkiss RS, et al. Among authors: opal sm. Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. Nat Rev Dis Primers. 2016. PMID: 28117397 Free PMC article. Review.
With earlier recognition and more compliance to best practices, sepsis has become less of an immediate life-threatening disorder and more of a long-term chronic critical illness, often associated with prolonged inflammation, immune suppression, organ injury and lean tissue …
With earlier recognition and more compliance to best practices, sepsis has become less of an immediate life-threatening disorder and more of …
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; SCCM/ESICM/ACCP/ATS/SIS. Levy MM, et al. Among authors: opal sm. Crit Care Med. 2003 Apr;31(4):1250-6. doi: 10.1097/01.CCM.0000050454.01978.3B. Crit Care Med. 2003. PMID: 12682500 Review.
OBJECTIVE: In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were "to provide a conceptual and a practical framework to define the systemic inflammatory response to infec …
OBJECTIVE: In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus C …
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; International Sepsis Definitions Conference. Levy MM, et al. Among authors: opal sm. Intensive Care Med. 2003 Apr;29(4):530-8. doi: 10.1007/s00134-003-1662-x. Epub 2003 Mar 28. Intensive Care Med. 2003. PMID: 12664219 Review.
OBJECTIVE: In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were to "provide a conceptual and a practical framework to define the systemic inflammatory response to infec …
OBJECTIVE: In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus C …
Sepsis: frontiers in supportive care, organisation and research.
Perner A, Rhodes A, Venkatesh B, Angus DC, Martin-Loeches I, Preiser JC, Vincent JL, Marshall J, Reinhart K, Joannidis M, Opal SM. Perner A, et al. Among authors: opal sm. Intensive Care Med. 2017 Apr;43(4):496-508. doi: 10.1007/s00134-017-4677-4. Epub 2017 Jan 27. Intensive Care Med. 2017. PMID: 28130686 Review.
Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to healthcare systems and society. Despite recent progress, short- and long-term morbidity, mortality and costs remain high in both develope …
Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to heal …
Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock.
Shoji H, Opal SM. Shoji H, et al. Among authors: opal sm. Int J Mol Sci. 2021 Feb 23;22(4):2228. doi: 10.3390/ijms22042228. Int J Mol Sci. 2021. PMID: 33672437 Free PMC article. Review.
Following the findings derived from a large sepsis clinical trial with PMX in North America, a new trial is ongoing to determine if PMX has a long-term survival benefit when administered to septic patients. Another approach to support a survival benefit from intervention w …
Following the findings derived from a large sepsis clinical trial with PMX in North America, a new trial is ongoing to determine if PMX has …
A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens.
Wittebole X, De Roock S, Opal SM. Wittebole X, et al. Among authors: opal sm. Virulence. 2014 Jan 1;5(1):226-35. doi: 10.4161/viru.25991. Epub 2013 Aug 13. Virulence. 2014. PMID: 23973944 Free PMC article. Review.
The seemingly inexorable spread of antibiotic resistance genes among microbial pathogens now threatens the long-term viability of our current antimicrobial therapy to treat severe bacterial infections such as sepsis. ...
The seemingly inexorable spread of antibiotic resistance genes among microbial pathogens now threatens the long-term viability of our …
Role of Toll-like receptors in infection and immunity: clinical implications.
Cristofaro P, Opal SM. Cristofaro P, et al. Among authors: opal sm. Drugs. 2006;66(1):15-29. doi: 10.2165/00003495-200666010-00002. Drugs. 2006. PMID: 16398566 Review.
Among the common and important processes in which TLRs play a role are asthma, acute respiratory distress syndrome, cardiac ischaemia, coronary artery disease, ventricular remodelling, vascular collapse, inflammatory bowel disease, acute tubular necrosis, psoriasis, rheumatoid ar …
Among the common and important processes in which TLRs play a role are asthma, acute respiratory distress syndrome, cardiac ischaemia, coron …
Severe sepsis and septic shock: defining the clinical problem.
Opal SM. Opal SM. Scand J Infect Dis. 2003;35(9):529-34. doi: 10.1080/00365540310015917. Scand J Infect Dis. 2003. PMID: 14620131 Review.
The problem of sepsis is further complicated by the remarkably diverse spectrum of illness encompassed under the term 'sepsis'. Sepsis may range in severity from mild systemic inflammation without significant clinical consequences to multisystem failure in septic shock wit …
The problem of sepsis is further complicated by the remarkably diverse spectrum of illness encompassed under the term 'sepsis'. Sepsi …
12 results