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Cystic fibrosis liver disease in the new era of cystic fibrosis transmembrane conductance regulator (CFTR) modulators.
Eldredge JA, Oliver MR, Ooi CY. Eldredge JA, et al. Among authors: ooi cy. Paediatr Respir Rev. 2023 Dec 28:S1526-0542(23)00087-8. doi: 10.1016/j.prrv.2023.12.005. Online ahead of print. Paediatr Respir Rev. 2023. PMID: 38281822 Free article. Review.
Cystic Fibrosis Transmembrane Conductance Receptor (CFTR) modulators may be transformative on pulmonary, nutritional and quality of life, but direct effect on long term liver disease outcomes is not yet established. Drug-associated hepatic adverse effects may be common, an …
Cystic Fibrosis Transmembrane Conductance Receptor (CFTR) modulators may be transformative on pulmonary, nutritional and quality of life, bu …
Children With Cystic Fibrosis Have Elevated Levels of Fecal Chitinase-3-like-1.
Permain J, Appleton L, Ho SSC, Coffey M, Ooi CY, Keenan JI, Day AS. Permain J, et al. Among authors: ooi cy. J Pediatr Gastroenterol Nutr. 2022 Jul 1;75(1):48-51. doi: 10.1097/MPG.0000000000003477. Epub 2022 May 27. J Pediatr Gastroenterol Nutr. 2022. PMID: 35622011
Further work is required to confirm the current findings and to ascertain the longer-term significance of elevated CHI3L1....
Further work is required to confirm the current findings and to ascertain the longer-term significance of elevated CHI3L1....
Intestinal Inflammation and Alterations in the Gut Microbiota in Cystic Fibrosis: A Review of the Current Evidence, Pathophysiology and Future Directions.
Tam RY, van Dorst JM, McKay I, Coffey M, Ooi CY. Tam RY, et al. Among authors: ooi cy. J Clin Med. 2022 Jan 27;11(3):649. doi: 10.3390/jcm11030649. J Clin Med. 2022. PMID: 35160099 Free PMC article. Review.
Additionally, a growing body of evidence suggests that these GI manifestations may have significant clinical associations with growth and nutrition, quality of life, and respiratory function in CF. As such, the potential utility of GI therapies and long-term GI outcomes ar …
Additionally, a growing body of evidence suggests that these GI manifestations may have significant clinical associations with growth and nu …
Vascular Complications in Pediatric Pancreatitis: A Case Series.
Dike CR, Cress G, Fishman DS, Gonska T, Ooi CY, Perito ER, Troendle D, Tsai CM, Lowe ME, Uc A. Dike CR, et al. Among authors: ooi cy. J Pediatr Gastroenterol Nutr. 2021 Oct 1;73(4):e94-e97. doi: 10.1097/MPG.0000000000003218. J Pediatr Gastroenterol Nutr. 2021. PMID: 34224489 Free PMC article.
Anti-coagulants appear to be safe in children with acute pancreatitis, their long-term benefit needs to be further investigated....
Anti-coagulants appear to be safe in children with acute pancreatitis, their long-term benefit needs to be further investigated....
Immunoreactive trypsinogen levels in newborn screened infants with an inconclusive diagnosis of cystic fibrosis.
Ooi CY, Sutherland R, Castellani C, Keenan K, Boland M, Reisman J, Bjornson C, Chilvers MA, van Wylick R, Kent S, Price A, Mateos-Corral D, Hughes D, Solomon M, Zuberbuhler P, Brusky J, Durie PR, Ratjen F, Gonska T. Ooi CY, et al. BMC Pediatr. 2019 Oct 22;19(1):369. doi: 10.1186/s12887-019-1756-4. BMC Pediatr. 2019. PMID: 31640630 Free PMC article.
CF transmembrane conductance regulator (CFTR)-related metabolic syndrome (CRMS) or CF screen positive inconclusive diagnosis (CFSPID). These infants have an uncertain long-term outcome and it is currently unclear around time of diagnosis, which infants are at higher risk o …
CF transmembrane conductance regulator (CFTR)-related metabolic syndrome (CRMS) or CF screen positive inconclusive diagnosis (CFSPID). These …
Paediatric Patients with Coeliac Disease on a Gluten-Free Diet: Nutritional Adequacy and Macro- and Micronutrient Imbalances.
Sue A, Dehlsen K, Ooi CY. Sue A, et al. Among authors: ooi cy. Curr Gastroenterol Rep. 2018 Jan 22;20(1):2. doi: 10.1007/s11894-018-0606-0. Curr Gastroenterol Rep. 2018. PMID: 29356956 Review.
The potential implications of these inadequacies, both short and long term, remain unclear and warrant further investigation and clarification....
The potential implications of these inadequacies, both short and long term, remain unclear and warrant further investigation and clar …
Early Posthepatoportoenterostomy Predictors of Native Liver Survival in Biliary Atresia.
Nightingale S, Stormon MO, O'Loughlin EV, Shun A, Thomas G, Benchimol EI, Day AS, Adams S, Shi E, Ooi CY, Kamath BM, Fecteau A, Langer JC, Roberts EA, Ling SC, Ng VL. Nightingale S, et al. Among authors: ooi cy. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):203-209. doi: 10.1097/MPG.0000000000001289. J Pediatr Gastroenterol Nutr. 2017. PMID: 28107282

TB and albumin levels 3 months post-HPE defined 3 groups (1: TB 74 mumol/L, albumin >35 g/L; 2: TB 74 mumol/L, albumin 35 g/L; 3: TB >74 mumol/L) with distinct short- and long-term native liver survival rates (log-rank P < 0.001). Length z scores 3 months post-HPE

…
TB and albumin levels 3 months post-HPE defined 3 groups (1: TB 74 mumol/L, albumin >35 g/L; 2: TB 74 mumol/L, albumin 35 g/L; 3: TB > …
Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.
Gariepy CE, Heyman MB, Lowe ME, Pohl JF, Werlin SL, Wilschanski M, Barth B, Fishman DS, Freedman SD, Giefer MJ, Gonska T, Himes R, Husain SZ, Morinville VD, Ooi CY, Schwarzenberg SJ, Troendle DM, Yen E, Uc A. Gariepy CE, et al. Among authors: ooi cy. J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):95-103. doi: 10.1097/MPG.0000000000001446. J Pediatr Gastroenterol Nutr. 2017. PMID: 27782962 Free PMC article.
RESULTS: The panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies of these disorders, and long-term monitoring. Statements for which the group reached consensus to make no recommendation or could not …
RESULTS: The panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies …
Are children on jejunal feeds at risk of iron deficiency?
Tan LZ, Adams SE, Kennedy A, Kepreotes H, Ooi CY. Tan LZ, et al. Among authors: ooi cy. World J Gastroenterol. 2015 May 14;21(18):5751-4. doi: 10.3748/wjg.v21.i18.5751. World J Gastroenterol. 2015. PMID: 25987804 Free PMC article.
This may be the result of small bowel adaptation in response to early iron deficiency. Larger and longer term prospective studies are required to investigate if children on jejunal feeds are at risk of developing iron deficiency....
This may be the result of small bowel adaptation in response to early iron deficiency. Larger and longer term prospective studies are …
Are thiopurines always contraindicated after thiopurine-induced pancreatitis in inflammatory bowel disease?
Ledder OD, Lemberg DA, Ooi CY, Day AS. Ledder OD, et al. Among authors: ooi cy. J Pediatr Gastroenterol Nutr. 2013 Nov;57(5):583-6. doi: 10.1097/MPG.0b013e31829f16fc. J Pediatr Gastroenterol Nutr. 2013. PMID: 23783022
The clinical relevance of this option is most marked in patients with complicated disease requiring long-term immunosuppression, in whom other therapies are poorly tolerated or contraindicated....
The clinical relevance of this option is most marked in patients with complicated disease requiring long-term immunosuppression, in w …