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Trans men can achieve adequate muscular development through low-dose testosterone therapy: A long-term study on body composition changes.
Tominaga Y, Kobayashi T, Matsumoto Y, Moriwake T, Oshima Y, Okumura M, Horii S, Sadahira T, Katayama S, Iwata T, Nishimura S, Bekku K, Edamura K, Sugimoto M, Kobayashi Y, Watanabe M, Namba Y, Matsumoto Y, Nakatsuka M, Araki M. Tominaga Y, et al. Among authors: okumura m. Andrology. 2024 Apr 2. doi: 10.1111/andr.13640. Online ahead of print. Andrology. 2024. PMID: 38563871
BACKGROUND: Transgender individuals undergo the gender-affirming hormone therapy (GAHT) to achieve physical changes consistent with their gender identity. Few studies are available on the long-term safety and efficacy of GAHT. OBJECTIVES: To investigate the long-term
BACKGROUND: Transgender individuals undergo the gender-affirming hormone therapy (GAHT) to achieve physical changes consistent with their ge …
Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells.
Konishi H, Haga Y, Okumura M, Tsujino H, Higashisaka K, Tsutsumi Y. Konishi H, et al. Among authors: okumura m. Cell Death Discov. 2024 Mar 1;10(1):108. doi: 10.1038/s41420-024-01884-w. Cell Death Discov. 2024. PMID: 38429255 Free PMC article.
However, some cancer types are refractory to molecular targeted therapies or acquire drug resistance after long-term treatment. Thus, ferroptosis, a newly defined type of programmed cell death caused by the iron-dependent accumulation of lipid peroxidation, has gained atte …
However, some cancer types are refractory to molecular targeted therapies or acquire drug resistance after long-term treatment. Thus, …
High Incidence Rates of Early-onset Bacterial Sepsis in Infants Born in Two Brazilian Maternities: A 15-Year Retrospective Analysis.
Okumura MC, Aragon DC, Carvalheiro CG, Quintana SM, Mussi-Pinhata MM. Okumura MC, et al. Pediatr Infect Dis J. 2024 Mar 1;43(3):271-277. doi: 10.1097/INF.0000000000004196. Epub 2024 Jan 18. Pediatr Infect Dis J. 2024. PMID: 38241655
CONCLUSIONS: EOBS remains unacceptably high and is frequently fatal in preterm and term infants cared for in high- or low-risk maternities. Because GBS has emerged as the most frequent causative agent, preventive strategies are urgently needed....
CONCLUSIONS: EOBS remains unacceptably high and is frequently fatal in preterm and term infants cared for in high- or low-risk matern …
Stereotactic radiotherapy for ventricular tachycardia: A study protocol.
Kawamura M, Shimojo M, Inden Y, Kamomae T, Okudaira K, Komada T, Aoki S, Shindo Y, Yasui R, Yanagi Y, Okumura M, Yamada T, Kozai Y, Oie Y, Kato Y, Ishihara S, Murohara T, Naganawa S. Kawamura M, et al. Among authors: okumura m. F1000Res. 2023 Dec 12;12:798. doi: 10.12688/f1000research.138758.2. eCollection 2023. F1000Res. 2023. PMID: 38204487 Free PMC article.
METHODS: This is a protocol paper for a feasibility study designed to provide stereotactic radiotherapy for refractory VT not cured by catheter ablation after at least one catheter ablation. The primary end point is to evaluate the short-term safety of this treatment and t …
METHODS: This is a protocol paper for a feasibility study designed to provide stereotactic radiotherapy for refractory VT not cured by cathe …
Conversion of raltegravir carrying a 1,3,4-oxadiazole ring to a hydrolysis product upon pH changes decreases its antiviral activity.
Nakamura T, Okumura M, Takamune N, Hirotsu T, Sugiura M, Yasunaga J, Nakata H. Nakamura T, et al. Among authors: okumura m. PNAS Nexus. 2023 Dec 18;3(1):pgad446. doi: 10.1093/pnasnexus/pgad446. eCollection 2024 Jan. PNAS Nexus. 2023. PMID: 38170115 Free PMC article.
Although clinical trials are needed for evaluation, we anticipate that protective devices such as betaCDs may improve the pharmacokinetics of RAL, leading to better treatment outcomes, including reduced dosing, long-term anti-HIV-1 activity, and deeper HIV-1 suppression... …
Although clinical trials are needed for evaluation, we anticipate that protective devices such as betaCDs may improve the pharmacokinetics o …
Evaluation of the Impact of ABCDEF Bundle Compliance Rates on Postintensive Care Syndrome: A Secondary Analysis Study.
Kawakami D, Fujitani S, Koga H, Dote H, Takita M, Takaba A, Hino M, Nakamura M, Irie H, Adachi T, Shibata M, Kataoka J, Korenaga A, Yamashita T, Okazaki T, Okumura M, Tsunemitsu T. Kawakami D, et al. Among authors: okumura m. Crit Care Med. 2023 Dec 1;51(12):1685-1696. doi: 10.1097/CCM.0000000000005980. Epub 2023 Jun 23. Crit Care Med. 2023. PMID: 37971720
OBJECTIVES: This study aimed to examine the association between ABCDEF bundles and long-term postintensive care syndrome (PICS)-related outcomes. DESIGN: Secondary analysis of the J-PICS study. ...
OBJECTIVES: This study aimed to examine the association between ABCDEF bundles and long-term postintensive care syndrome (PICS)-relat …
Acetonyl Peroxy and Hydroperoxy Self- and Cross-Reactions: Temperature-Dependent Kinetic Parameters, Branching Fractions, and Chaperone Effects.
Zuraski K, Grieman FJ, Hui AO, Cowen J, Winiberg FAF, Percival CJ, Okumura M, Sander SP. Zuraski K, et al. Among authors: okumura m. J Phys Chem A. 2023 Sep 21;127(37):7772-7792. doi: 10.1021/acs.jpca.3c03660. Epub 2023 Sep 8. J Phys Chem A. 2023. PMID: 37683115 Free PMC article.
The HO(2) self-reaction rate coefficient was determined to be k(4) = (3.34(-0.80)(+1.04)) 10(-13) exp [(507 76)/T]cm(3) molecule(-1) s(-1) with the enhancement term k(4,M)(") = (2.7(-1.7)(+4.7)) 10(-36) exp [(4700 255)/T]cm(6) molecule(-2) s(-1), proportional to [CH(3)OH], …
The HO(2) self-reaction rate coefficient was determined to be k(4) = (3.34(-0.80)(+1.04)) 10(-13) exp [(507 76)/T]cm(3) molecule(-1) s(-1) w …
Long-term outcomes following surgical treatment for thymic epithelial tumor in Japan and an analysis of prognostic factors based on the Japanese Association for Research on the Thymus nationwide database.
Okumura M, Yoshino I, Funaki S, Okuda K, Watanabe SI, Tsuboi M, Shimizu K, Date H, Chen-Yoshikawa TF, Nakajima J, Toyooka S, Asamura H. Okumura M, et al. Surg Today. 2023 Nov;53(11):1247-1259. doi: 10.1007/s00595-023-02705-w. Epub 2023 Jul 17. Surg Today. 2023. PMID: 37460670
Treatment with Interleukin-25 Suppresses Short-Term High-Fructose Diet-Induced Hepatic Gene Expression and Activities of Fatty Acid Synthesis Enzymes in Rats.
Shimada M, Shirouchi B, Kobayashi Y, Higuchi M, Okumura M, Nakagawa T, Hayakawa T. Shimada M, et al. Among authors: okumura m. J Oleo Sci. 2023;72(1):99-104. doi: 10.5650/jos.ess22266. J Oleo Sci. 2023. PMID: 36624060 Free article.
This study aimed to investigate the effects of interleukin-25, which belongs to the interleukin-17 family, on short-term high-fructose diet-induced hepatic triacylglycerol accumulation. ...These results suggest that treatment with interleukin-25 suppresses short-term
This study aimed to investigate the effects of interleukin-25, which belongs to the interleukin-17 family, on short-term high-fructos …
Canagliflozin independently reduced plasma volume from conventional diuretics in patients with type 2 diabetes and chronic heart failure: a subanalysis of the CANDLE trial.
Shiina K, Tomiyama H, Tanaka A, Imai T, Hisauchi I, Taguchi I, Sezai A, Toyoda S, Dohi K, Kamiya H, Kida K, Anzai T, Chikamori T, Node K; CANDLE trial investigators. Shiina K, et al. Hypertens Res. 2023 Feb;46(2):495-506. doi: 10.1038/s41440-022-01085-x. Epub 2022 Nov 15. Hypertens Res. 2023. PMID: 36380202
Furthermore, canagliflozin significantly reduced serum uric acid without causing major electrolyte abnormalities in patients in both subgroups. The long-term beneficial effect of SGLT2i on intravascular congestion could be independent of conventional diuretic therapy witho …
Furthermore, canagliflozin significantly reduced serum uric acid without causing major electrolyte abnormalities in patients in both subgrou …
72 results