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Page 1
Aldosterone contributes to hypertension in male mice inducibly overexpressing human endothelin-1 in endothelium.
Berillo O, Coelho SC, Mahjoub N, Offermanns S, Paradis P, Schiffrin EL. Berillo O, et al. Among authors: offermanns s. J Hypertens. 2021 Sep 1;39(9):1908-1917. doi: 10.1097/HJH.0000000000002880. J Hypertens. 2021. PMID: 34039912
OBJECTIVE: Mechanisms of blood pressure (BP) regulation by endothelin (ET)-1 produced by endothelial cells are complex and remain unclear. Long-term exposure to human ET-1 (hET-1) in mice inducibly overexpressing hET-1 in the endothelium (ieET-1) caused sustained BP elevat …
OBJECTIVE: Mechanisms of blood pressure (BP) regulation by endothelin (ET)-1 produced by endothelial cells are complex and remain unclear. L …
Do dimethyl fumarate and nicotinic acid elicit common, potentially HCA2 -mediated adverse reactions? A combined epidemiological-experimental approach.
Dubrall D, Pflock R, Kosinska J, Schmid M, Bleich M, Himmerkus N, Offermanns S, Schwaninger M, Sachs B. Dubrall D, et al. Among authors: offermanns s. Br J Clin Pharmacol. 2021 Oct;87(10):3813-3824. doi: 10.1111/bcp.14787. Epub 2021 Mar 24. Br J Clin Pharmacol. 2021. PMID: 33605454 Free article.
A discrepant ADR profile was seen for "lymphopenia" (n = 777) at the preferred term level (only reported for dimethyl fumarate) and "blood glucose increased" (more often reported for nicotinic acid; OR 0.1 [0.0-0.5]). ...
A discrepant ADR profile was seen for "lymphopenia" (n = 777) at the preferred term level (only reported for dimethyl fumarate) and " …
Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function.
Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. Bibli SI, et al. Among authors: offermanns s. Circulation. 2021 Mar 2;143(9):935-948. doi: 10.1161/CIRCULATIONAHA.120.051877. Epub 2020 Dec 14. Circulation. 2021. PMID: 33307764
CONCLUSIONS: Vascular disease is associated with marked changes in the S-sulfhydration of endothelial cell proteins involved in mediating responses to flow. Short-term H(2)S(n) supplementation improved vascular reactivity in humans highlighting the potential of interfering …
CONCLUSIONS: Vascular disease is associated with marked changes in the S-sulfhydration of endothelial cell proteins involved in mediating re …
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Alexander SPH, et al. Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S21-S141. doi: 10.1111/bph.14748. Br J Pharmacol. 2019. PMID: 31710717 Free PMC article. Review.
Three-Month Endothelial Human Endothelin-1 Overexpression Causes Blood Pressure Elevation and Vascular and Kidney Injury.
Coelho SC, Berillo O, Caillon A, Ouerd S, Fraulob-Aquino JC, Barhoumi T, Offermanns S, Paradis P, Schiffrin EL. Coelho SC, et al. Among authors: offermanns s. Hypertension. 2018 Jan;71(1):208-216. doi: 10.1161/HYPERTENSIONAHA.117.09925. Epub 2017 Nov 13. Hypertension. 2018. PMID: 29133362
We have shown that tamoxifen-inducible endothelium-restricted human ET-1 overexpressing (ieET-1) mice exhibited blood pressure rise after a 3-week induction in an ET type A (ET(A)) receptor-dependent manner, in absence of vascular and renal injury. It is unknown whether long-t …
We have shown that tamoxifen-inducible endothelium-restricted human ET-1 overexpressing (ieET-1) mice exhibited blood pressure rise after a …
Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action.
Schreier B, Hünerberg M, Rabe S, Mildenberger S, Bethmann D, Heise C, Sibilia M, Offermanns S, Gekle M. Schreier B, et al. Among authors: offermanns s. Clin Sci (Lond). 2016 Jan;130(1):19-33. doi: 10.1042/CS20150503. Epub 2015 Oct 5. Clin Sci (Lond). 2016. PMID: 26438881
Vascular EGFR has been proposed to be involved in vascular tissue homoeostasis and remodelling. Thus, most studies have focused on its role during long-term vascular changes whereas the relevance for acute regulation of vascular function in vivo and ex vivo is insufficient …
Vascular EGFR has been proposed to be involved in vascular tissue homoeostasis and remodelling. Thus, most studies have focused on its role …
A novel luminescence-based method for the detection of functionally active antibodies to muscarinic acetylcholine receptors of the M3 type (mAchR3) in patients' sera.
Preuss B, Tunaru S, Henes J, Offermanns S, Klein R. Preuss B, et al. Among authors: offermanns s. Clin Exp Immunol. 2014 Jul;177(1):179-89. doi: 10.1111/cei.12324. Clin Exp Immunol. 2014. PMID: 24628494 Free PMC article.
Optimal assay conditions were obtained with a cell density of 100 000 cells/ml, isolation of Ig by ammonium sulphate precipitation and short-term incubation. Based on this highly reliable assay, 50% of the pSS patients had antibodies which inhibited carbachol-induced activ …
Optimal assay conditions were obtained with a cell density of 100 000 cells/ml, isolation of Ig by ammonium sulphate precipitation and short …
RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades.
Takefuji M, Krüger M, Sivaraj KK, Kaibuchi K, Offermanns S, Wettschureck N. Takefuji M, et al. Among authors: offermanns s. J Exp Med. 2013 Apr 8;210(4):665-73. doi: 10.1084/jem.20122126. Epub 2013 Mar 25. J Exp Med. 2013. PMID: 23530122 Free PMC article.
Importantly, in mice with preexisting hypertrophy, induction of RhoGEF12 deficiency protects from cardiac decompensation, resulting in significantly increased long-term survival. Collectively, RhoGEF12 acts as an integrator of stretch-induced signaling cascades in cardiomy …
Importantly, in mice with preexisting hypertrophy, induction of RhoGEF12 deficiency protects from cardiac decompensation, resulting in signi …
Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.
Benyó Z, Gille A, Bennett CL, Clausen BE, Offermanns S. Benyó Z, et al. Among authors: offermanns s. Mol Pharmacol. 2006 Dec;70(6):1844-9. doi: 10.1124/mol.106.030833. Epub 2006 Sep 28. Mol Pharmacol. 2006. PMID: 17008386
Nicotinic acid-induced flushing has been shown to be mediated by the nicotinic acid receptor GPR109A and to involve the formation of vasodilatory prostanoids. However, the cellular mechanisms underlying this short-term effect are unknown. Here, we show that epidermal Lange …
Nicotinic acid-induced flushing has been shown to be mediated by the nicotinic acid receptor GPR109A and to involve the formation of vasodil …
Distinct roles of Galpha(q) and Galpha11 for Purkinje cell signaling and motor behavior.
Hartmann J, Blum R, Kovalchuk Y, Adelsberger H, Kuner R, Durand GM, Miyata M, Kano M, Offermanns S, Konnerth A. Hartmann J, et al. Among authors: offermanns s. J Neurosci. 2004 Jun 2;24(22):5119-30. doi: 10.1523/JNEUROSCI.4193-03.2004. J Neurosci. 2004. PMID: 15175381 Free PMC article.
By using whole-cell recordings and Ca2+ imaging in Purkinje cells, we show that Galpha(q) is required for mGluR-dependent synaptic transmission and for long-term depression (LTD). Galpha11 has no detectable contribution for synaptic transmission but also contributes to LTD …
By using whole-cell recordings and Ca2+ imaging in Purkinje cells, we show that Galpha(q) is required for mGluR-dependent synaptic transmiss …
15 results