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Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells.
Katsuda T, Sussman J, Li J, Merrell AJ, Vostrejs W, Secreto A, Matsuzaki J, Ochiya T, Stanger BZ. Katsuda T, et al. Among authors: ochiya t. Stem Cell Reports. 2023 Jul 11;18(7):1436-1450. doi: 10.1016/j.stemcr.2023.05.016. Epub 2023 Jun 22. Stem Cell Reports. 2023. PMID: 37352852 Free PMC article.
Unexpectedly, we also found that the CLiP method allows biliary epithelial cells to acquire extensive proliferative capacity. Interestingly, after long-term culture, hepatocyte-derived cells (hepCLiPs) and biliary epithelial cell-derived cells (bilCLiPs) become similar in …
Unexpectedly, we also found that the CLiP method allows biliary epithelial cells to acquire extensive proliferative capacity. Interestingly, …
Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells.
Katsuda T, Li J, Merrell AJ, Sussman J, Matsuzaki J, Ochiya T, Stanger BZ. Katsuda T, et al. Among authors: ochiya t. bioRxiv [Preprint]. 2023 Jan 3:2023.01.03.522656. doi: 10.1101/2023.01.03.522656. bioRxiv. 2023. PMID: 36712014 Free PMC article. Updated. Preprint.
Unexpectedly, we also found that the CLiP method allows biliary epithelial cells to acquire extensive proliferative capacity. Interestingly, after long-term culture, hepatocyte-derived cells (hepCLiPs) and biliary-derived cells (bilCLiPs) become similar in their gene expre …
Unexpectedly, we also found that the CLiP method allows biliary epithelial cells to acquire extensive proliferative capacity. Interestingly, …
Circulating microRNA profiling for prediction of oncological outcomes in prostate cancer patients following radical prostatectomy.
Takamori H, Urabe F, Matsuzaki J, Kimura S, Sasaki H, Kimura T, Inaba K, Nakamura E, Matsui Y, Fujimoto H, Ochiya T. Takamori H, et al. Among authors: ochiya t. Prostate. 2022 Dec;82(16):1537-1546. doi: 10.1002/pros.24427. Epub 2022 Aug 16. Prostate. 2022. PMID: 35971801
BACKGROUND: Although radical prostatectomy is associated with good long-term oncological outcomes, approximately 30% of patients present biochemical recurrence, whereupon salvage treatments are required. ...
BACKGROUND: Although radical prostatectomy is associated with good long-term oncological outcomes, approximately 30% of patients pres …
Independent verification of circulating miRNA as diagnostic biomarkers for urothelial carcinoma.
Urabe F, Matsuzaki J, Takeshita F, Kishida T, Ochiya T, Hirai K. Urabe F, et al. Among authors: ochiya t. Cancer Sci. 2022 Oct;113(10):3510-3517. doi: 10.1111/cas.15496. Epub 2022 Aug 12. Cancer Sci. 2022. PMID: 35848873 Free PMC article.
Urothelial carcinoma (UC) is an umbrella term for bladder cancers (BCa) and upper-tract urothelial carcinoma (UTUC), with BCa and UTUC sometimes detected concomitantly. ...
Urothelial carcinoma (UC) is an umbrella term for bladder cancers (BCa) and upper-tract urothelial carcinoma (UTUC), with BCa and UTU …
SORT1/LAMP2-mediated extracellular vesicle secretion and cell adhesion are linked to lenalidomide resistance in multiple myeloma.
Yamamoto T, Nakayama J, Yamamoto Y, Kuroda M, Hattori Y, Ochiya T. Yamamoto T, et al. Among authors: ochiya t. Blood Adv. 2022 Apr 26;6(8):2480-2495. doi: 10.1182/bloodadvances.2021005772. Blood Adv. 2022. PMID: 34979567 Free PMC article.
Multiple myeloma (MM) is a hematopoietic malignancy whose prognosis has improved with the development of new agents such as lenalidomide over the last decade. However, long-term exposure to drugs induces the acquisition of resistance by MM cells and leads to treatment fail …
Multiple myeloma (MM) is a hematopoietic malignancy whose prognosis has improved with the development of new agents such as lenalidomide ove …
Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo.
Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Tanimizu N, et al. Among authors: ochiya t. Nat Commun. 2021 Jun 7;12(1):3390. doi: 10.1038/s41467-021-23575-1. Nat Commun. 2021. PMID: 34099675 Free PMC article.
Hepatocytes in HBTO acquire and maintain metabolic functions including albumin secretion and cytochrome P450 activities, over the long term. In this study, we establish functional liver tissue incorporating a bile drainage system ex vivo. ...
Hepatocytes in HBTO acquire and maintain metabolic functions including albumin secretion and cytochrome P450 activities, over the long te …
Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.
Gimona M, Brizzi MF, Choo ABH, Dominici M, Davidson SM, Grillari J, Hermann DM, Hill AF, de Kleijn D, Lai RC, Lai CP, Lim R, Monguió-Tortajada M, Muraca M, Ochiya T, Ortiz LA, Toh WS, Yi YW, Witwer KW, Giebel B, Lim SK. Gimona M, et al. Among authors: ochiya t. Cytotherapy. 2021 May;23(5):373-380. doi: 10.1016/j.jcyt.2021.01.001. Epub 2021 Apr 10. Cytotherapy. 2021. PMID: 33934807
However, it is increasingly clear that MSCs exert their therapeutic functions in a paracrine manner through the secretion of small extracellular vesicles (sEVs) of 50-200 nm in diameter. Unlike living cells that can persist long-term, sEVs are non-living and non-replicativ …
However, it is increasingly clear that MSCs exert their therapeutic functions in a paracrine manner through the secretion of small extracell …
Differentiation of chemically induced liver progenitor cells to cholangiocytes: Investigation of the optimal conditions.
Huang Y, Sakai Y, Hara T, Katsuda T, Ochiya T, Gu WL, Miyamoto D, Hamada T, Kanetaka K, Adachi T, Eguchi S. Huang Y, et al. Among authors: ochiya t. J Biosci Bioeng. 2020 Nov;130(5):545-552. doi: 10.1016/j.jbiosc.2020.07.009. Epub 2020 Aug 9. J Biosci Bioeng. 2020. PMID: 32782195
Matrigel provided cells with space to form three-dimensional (3D) structures, but the long-term use of Matrigel from the induction step did not benefit the differentiation of CLiPs to cholangiocytes. ...
Matrigel provided cells with space to form three-dimensional (3D) structures, but the long-term use of Matrigel from the induction st …
Extracellular Vesicles in Cancer Metastasis: Potential as Therapeutic Targets and Materials.
Kogure A, Yoshioka Y, Ochiya T. Kogure A, et al. Among authors: ochiya t. Int J Mol Sci. 2020 Jun 23;21(12):4463. doi: 10.3390/ijms21124463. Int J Mol Sci. 2020. PMID: 32585976 Free PMC article. Review.
Recent studies have shown that communication between cancer cells and surrounding cells enables cancer progression and metastasis. The comprehensive term "extracellular vesicles" (EVs) describes lipid bilayer vesicles that are secreted to outside cells; EVs are well-establ …
Recent studies have shown that communication between cancer cells and surrounding cells enables cancer progression and metastasis. The compr …
26 results