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Mild Cystic Fibrosis Lung Disease Is Associated with Bacterial Community Stability.
Hampton TH, Thomas D, van der Gast C, O'Toole GA, Stanton BA. Hampton TH, et al. Among authors: o toole ga. Microbiol Spectr. 2021 Sep 3;9(1):e0002921. doi: 10.1128/Spectrum.00029-21. Epub 2021 Jul 7. Microbiol Spectr. 2021. PMID: 34232099 Free PMC article.
Microbial communities in the airways of persons with CF (pwCF) are variable, may include genera that are not typically associated with CF, and their composition can be difficult to correlate with long-term disease outcomes. Leveraging two large data sets characterizing spu …
Microbial communities in the airways of persons with CF (pwCF) are variable, may include genera that are not typically associated with CF, a …
Pseudomonas aeruginosa Uses c-di-GMP Phosphodiesterases RmcA and MorA To Regulate Biofilm Maintenance.
Katharios-Lanwermeyer S, Whitfield GB, Howell PL, O'Toole GA. Katharios-Lanwermeyer S, et al. Among authors: o toole ga. mBio. 2021 Feb 2;12(1):e03384-20. doi: 10.1128/mBio.03384-20. mBio. 2021. PMID: 33531388 Free PMC article.
Despite an improved understanding of how biofilms initially form, the processes that facilitate the long-term maintenance of these multicellular communities remain opaque. ...
Despite an improved understanding of how biofilms initially form, the processes that facilitate the long-term maintenance of these mu …
Discovering the Molecular Determinants of Phaeobacter inhibens Susceptibility to Phaeobacter Phage MD18.
Urtecho G, Campbell DE, Hershey DM, Hussain FA, Whitaker RJ, O'Toole GA. Urtecho G, et al. Among authors: o toole ga. mSphere. 2020 Nov 4;5(6):e00898-20. doi: 10.1128/mSphere.00898-20. mSphere. 2020. PMID: 33148823 Free PMC article.
Network analysis of these genes using genomic position, Gene Ontology (GO) term enrichment, and protein associations revealed that these genes are enriched for roles in assembly of a type IV pilus (T4P) and regulators of cellular morphology. ...
Network analysis of these genes using genomic position, Gene Ontology (GO) term enrichment, and protein associations revealed that th …
Pseudomonas aeruginosa-Derived Rhamnolipids and Other Detergents Modulate Colony Morphotype and Motility in the Burkholderia cepacia Complex.
Bernier SP, Hum C, Li X, O'Toole GA, Magarvey NA, Surette MG. Bernier SP, et al. Among authors: o toole ga. J Bacteriol. 2017 Jun 13;199(13):e00171-17. doi: 10.1128/JB.00171-17. Print 2017 Jul 1. J Bacteriol. 2017. PMID: 28439038 Free PMC article.
Consequently, improving the molecular understanding of these interactions could provide us with new insights on the possible long-term consequences of these chronic infections. In this study, we show that P. aeruginosa-derived rhamnolipids, which participate in Bcc killing …
Consequently, improving the molecular understanding of these interactions could provide us with new insights on the possible long-term …
Cyanide Toxicity to Burkholderia cenocepacia Is Modulated by Polymicrobial Communities and Environmental Factors.
Bernier SP, Workentine ML, Li X, Magarvey NA, O'Toole GA, Surette MG. Bernier SP, et al. Among authors: o toole ga. Front Microbiol. 2016 May 18;7:725. doi: 10.3389/fmicb.2016.00725. eCollection 2016. Front Microbiol. 2016. PMID: 27242743 Free PMC article.
Here we show that modification of the environment (i.e., culture medium), long-term genetic adaptation of P. aeruginosa to the cystic fibrosis (CF) lung, or the addition of another bacterial species to the community can alter the sensitivity of Burkholderia cenocepacia to …
Here we show that modification of the environment (i.e., culture medium), long-term genetic adaptation of P. aeruginosa to the cystic …
Micro-patterned surfaces reduce bacterial colonization and biofilm formation in vitro: Potential for enhancing endotracheal tube designs.
May RM, Hoffman MG, Sogo MJ, Parker AE, O'Toole GA, Brennan AB, Reddy ST. May RM, et al. Among authors: o toole ga. Clin Transl Med. 2014 Apr 16;3:8. doi: 10.1186/2001-1326-3-8. eCollection 2014. Clin Transl Med. 2014. PMID: 24739529 Free PMC article.
METHODS: The top five pathogens associated with ETT-related pneumonia, Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Klebsiella pneumonia, Acinetobacter baumannii, and Escherichia coli, were evaluated for attachment to micro-patterned and un-patterne …
METHODS: The top five pathogens associated with ETT-related pneumonia, Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aerug …
Pouring salt on a wound: Pseudomonas aeruginosa virulence factors alter Na+ and Cl- flux in the lung.
Ballok AE, O'Toole GA. Ballok AE, et al. Among authors: o toole ga. J Bacteriol. 2013 Sep;195(18):4013-9. doi: 10.1128/JB.00339-13. Epub 2013 Jul 8. J Bacteriol. 2013. PMID: 23836869 Free PMC article. Review.
Recent work on the virulence factors alkaline protease (AprA) and CF transmembrane conductance regulator inhibitory factor (Cif) show that P. aeruginosa also perturbs epithelial ion transport and osmosis, which may be important for the long-term survival of this microbe in …
Recent work on the virulence factors alkaline protease (AprA) and CF transmembrane conductance regulator inhibitory factor (Cif) show that P …
The Pseudomonas aeruginosa magnesium transporter MgtE inhibits transcription of the type III secretion system.
Anderson GG, Yahr TL, Lovewell RR, O'Toole GA. Anderson GG, et al. Among authors: o toole ga. Infect Immun. 2010 Mar;78(3):1239-49. doi: 10.1128/IAI.00865-09. Epub 2009 Dec 22. Infect Immun. 2010. PMID: 20028803 Free PMC article.
Pseudomonas aeruginosa is an opportunistic pathogen that causes life-long pneumonia in individuals with cystic fibrosis (CF). These long-term infections are maintained by bacterial biofilm formation in the CF lung. ...
Pseudomonas aeruginosa is an opportunistic pathogen that causes life-long pneumonia in individuals with cystic fibrosis (CF). These long- …
Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis.
O'Toole GA, Kolter R. O'Toole GA, et al. Mol Microbiol. 1998 May;28(3):449-61. doi: 10.1046/j.1365-2958.1998.00797.x. Mol Microbiol. 1998. PMID: 9632250 Free article.
We have isolated transposon mutants defective for the initiation of biofilm formation, which we term surface attachment defective (sad). Molecular analysis of the sad mutants revealed that the ClpP protein (a component of the cytoplasmic Clp protease) participates in biofi …
We have isolated transposon mutants defective for the initiation of biofilm formation, which we term surface attachment defective (sa …