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Outcomes of COVID-19 in people with rheumatic and musculoskeletal disease in Ireland over the first 2 years of the pandemic.
Conway R, Nikiphorou E, Demetriou CA, Low C, Leamy K, Ryan JG, Kavanagh R, Fraser AD, Carey JJ, O'Connell P, Flood RM, Mullan RH, Kane DJ, Stafford F, Robinson PC, Liew JW, Grainger R, McCarthy GM; COVID-19 Global Rheumatology Alliance. Conway R, et al. Among authors: o connell p. Ir J Med Sci. 2023 Oct;192(5):2495-2500. doi: 10.1007/s11845-022-03265-7. Epub 2023 Jan 9. Ir J Med Sci. 2023. PMID: 36622628 Free PMC article.
Hospitalisation was more common with increasing age, gout, smoking, long-term glucocorticoid use, comorbidities, and specific comorbidities of cardiovascular and pulmonary disease, and cancer. ...Mortality was more common with increasing age, gout, smoking, long-term
Hospitalisation was more common with increasing age, gout, smoking, long-term glucocorticoid use, comorbidities, and specific comorbi …
Drug Stability: ICH versus Accelerated Predictive Stability Studies.
González-González O, Ramirez IO, Ramirez BI, O'Connell P, Ballesteros MP, Torrado JJ, Serrano DR. González-González O, et al. Among authors: o connell p. Pharmaceutics. 2022 Oct 28;14(11):2324. doi: 10.3390/pharmaceutics14112324. Pharmaceutics. 2022. PMID: 36365143 Free PMC article. Review.
Overall, ICH stability studies involve a drug substance tested under storage conditions and assess its thermal stability and sensitivity to moisture. The long-term testing should be performed over a minimum of 12 months at 25 C 2 C/60% RH 5% RH or at 30 C 2 C/65% RH 5% RH. …
Overall, ICH stability studies involve a drug substance tested under storage conditions and assess its thermal stability and sensitivity to …
Survey of Patient Knowledge and Awareness of "Sick Day Rules" in Rheumatology Patients on Long Term Glucocorticoid Therapy.
Courtney A, McDonnell E, Ng WL, Martin-Grace J, Tomkins M, Sherlock M, O'Connell P, Dunne H. Courtney A, et al. Among authors: o connell p. Ir Med J. 2022 Sep 15;115(8):655. Ir Med J. 2022. PMID: 36306262
Aims Rheumatic disease (RMD) patients treated with long-term glucocorticoids (GC) are at risk of developing tertiary adrenal insufficiency. With this survey we aimed to assess the knowledge of RMD patients taking long-term glucocorticoid therapy regarding risk of ad …
Aims Rheumatic disease (RMD) patients treated with long-term glucocorticoids (GC) are at risk of developing tertiary adrenal insuffic …
Long-term efficacy and safety of osilodrostat in Cushing's disease: final results from a Phase II study with an optional extension phase (LINC 2).
Fleseriu M, Biller BMK, Bertherat J, Young J, Hatipoglu B, Arnaldi G, O'Connell P, Izquierdo M, Pedroncelli AM, Pivonello R. Fleseriu M, et al. Among authors: o connell p. Pituitary. 2022 Dec;25(6):959-970. doi: 10.1007/s11102-022-01280-6. Epub 2022 Oct 11. Pituitary. 2022. PMID: 36219274 Free PMC article. Clinical Trial.
Here, we report long-term efficacy and safety data for osilodrostat following completion of an optional extension to LINC 2. ...Testosterone levels (females) decreased towards baseline levels during long-term follow-up, with no new or worsening cases of hirsutism du …
Here, we report long-term efficacy and safety data for osilodrostat following completion of an optional extension to LINC 2. ...Testo …
Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons.
Hawthorne WJ, Salvaris EJ, Chew YV, Burns H, Hawkes J, Barlow H, Hu M, Lew AM, Nottle MB, O'Connell PJ, Cowan PJ. Hawthorne WJ, et al. Among authors: o connell pj. Front Immunol. 2022 Jun 16;13:898948. doi: 10.3389/fimmu.2022.898948. eCollection 2022. Front Immunol. 2022. PMID: 35784286 Free PMC article.
Here we report that NICC from genetically modified (GM) pigs deleted for alphaGal and expressing the human complement regulators CD55 and CD59 can cure diabetes long-term in immunosuppressed baboons, with maximum graft survival exceeding 22 months. ...In conclusion, we dem …
Here we report that NICC from genetically modified (GM) pigs deleted for alphaGal and expressing the human complement regulators CD55 and CD …
Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
STARSurg Collaborative and EuroSurg Collaborative. STARSurg Collaborative and EuroSurg Collaborative. BJS Open. 2022 Jan 6;6(1):zrab150. doi: 10.1093/bjsopen/zrab150. BJS Open. 2022. PMID: 35179188 Free PMC article.
BACKGROUND: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. ...
BACKGROUND: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and …
Healthy food prescription incentive programme for adults with type 2 diabetes who are experiencing food insecurity: protocol for a randomised controlled trial, modelling and implementation studies.
Olstad DL, Beall R, Spackman E, Dunn S, Lipscombe LL, Williams K, Oster R, Scott S, Zimmermann GL, McBrien KA, Steer KJD, Chan CB, Tyminski S, Berkowitz S, Edwards AL, Saunders-Smith T, Tariq S, Popeski N, White L, Williamson T, L'Abbé M, Raine KD, Nejatinamini S, Naser A, Basualdo-Hammond C, Norris C, O'Connell P, Seidel J, Lewanczuk R, Cabaj J, Campbell DJT. Olstad DL, et al. Among authors: o connell p. BMJ Open. 2022 Feb 15;12(2):e050006. doi: 10.1136/bmjopen-2021-050006. BMJ Open. 2022. PMID: 35168964 Free PMC article.
A randomised controlled trial (RCT) will investigate programme effectiveness via impact on glycosylated haemoglobin (primary outcome), food insecurity, diet quality and other clinical and patient-reported outcomes. A modelling study will estimate longer-term programme effe …
A randomised controlled trial (RCT) will investigate programme effectiveness via impact on glycosylated haemoglobin (primary outcome), food …
Impact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.
STARSurg Collaborative. STARSurg Collaborative. BJS Open. 2021 Nov 9;5(6):zrab134. doi: 10.1093/bjsopen/zrab134. BJS Open. 2021. PMID: 35029656 Free PMC article.
BACKGROUND: The intermediate-term impact of acute kidney injury (AKI) in patients after major gastrointestinal and liver surgery has not been well characterized. ...
BACKGROUND: The intermediate-term impact of acute kidney injury (AKI) in patients after major gastrointestinal and liver surgery has …
Evaluating Community-Facing Virtual Modalities to Support Complex Neurological Populations During the COVID-19 Pandemic: Protocol for a Mixed Methods Study.
Brehon K, Carriere J, Churchill K, Loyola-Sanchez A, O'Connell P, Papathanassoglou E, MacIsaac R, Tavakoli M, Ho C, Pohar Manhas K. Brehon K, et al. Among authors: o connell p. JMIR Res Protoc. 2021 Jul 23;10(7):e28267. doi: 10.2196/28267. JMIR Res Protoc. 2021. PMID: 34101610 Free PMC article.
The second approach is a webinar series aimed at supporting self-management and social connectedness of individuals living with spinal cord injury. OBJECTIVE: The study aims to evaluate the short- and long-term impacts and sustainability of two virtual modalities (teleheal …
The second approach is a webinar series aimed at supporting self-management and social connectedness of individuals living with spinal cord …
Organizational changes in diabetic foot care practices for patients at low and moderate risk after implementing a comprehensive foot care program in Alberta, Canada.
Chan CB, Dmytruk K, Labbie M, O'Connell P. Chan CB, et al. Among authors: o connell p. J Foot Ankle Res. 2020 May 19;13(1):26. doi: 10.1186/s13047-020-00393-0. J Foot Ankle Res. 2020. PMID: 32430079 Free PMC article.

The proportion of primary care and home care/long-term care (HC/LTC) sites providing screening increased significantly (p < 0.05). ...Further analyses of outcomes such as incident lower limb amputation and long-term cost-effectiveness of pathway implementation ar

The proportion of primary care and home care/long-term care (HC/LTC) sites providing screening increased significantly (p < 0.05).

67 results