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Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin.
Karsa M, Kosciolek A, Bongers A, Mariana A, Failes T, Gifford AJ, Kees UR, Cheung LC, Kotecha RS, Arndt GM, Haber M, Norris MD, Sutton R, Lock RB, Henderson MJ, Somers K. Karsa M, et al. Among authors: norris md. Br J Cancer. 2021 Jul;125(1):55-64. doi: 10.1038/s41416-021-01332-x. Epub 2021 Apr 9. Br J Cancer. 2021. PMID: 33837299 Free PMC article.
BACKGROUND: The prognosis for high-risk childhood acute leukaemias remains dismal and established treatment protocols often cause long-term side effects in survivors. This study aims to identify more effective and safer therapeutics for these patients. ...
BACKGROUND: The prognosis for high-risk childhood acute leukaemias remains dismal and established treatment protocols often cause long-te …
Long-Term Outcomes After Surgical Pulmonary Arterioplasty and Risk Factors for Reintervention.
Cresalia NM, Armstrong AK, Romano JC, Norris MD, Yu S, Rocchini AP, Zampi JD. Cresalia NM, et al. Among authors: norris md. Ann Thorac Surg. 2018 Feb;105(2):622-628. doi: 10.1016/j.athoracsur.2017.06.012. Epub 2017 Sep 28. Ann Thorac Surg. 2018. PMID: 28964419
BACKGROUND: Although surgical patch arterioplasty is the conventional therapy for branch pulmonary artery (PA) stenosis, limited data exist on long-term outcomes. We examined the incidence of and risk factors for reintervention after surgical arterioplasty for branch PA st …
BACKGROUND: Although surgical patch arterioplasty is the conventional therapy for branch pulmonary artery (PA) stenosis, limited data exist …
Cone reconstruction in children with Ebstein anomaly: the Mayo Clinic experience.
Anderson HN, Dearani JA, Said SM, Norris MD, Pundi KN, Miller AR, Cetta ML, Eidem BW, O'Leary PW, Cetta F. Anderson HN, et al. Among authors: norris md. Congenit Heart Dis. 2014 May-Jun;9(3):266-71. doi: 10.1111/chd.12155. Epub 2013 Dec 23. Congenit Heart Dis. 2014. PMID: 24373319
CONCLUSIONS: CR in children and young adults with Ebstein anomaly can be performed with low early mortality and excellent durability at short-term follow-up. CR represents an important surgical option for young patients. ...CR should be considered prior to the deleterious …
CONCLUSIONS: CR in children and young adults with Ebstein anomaly can be performed with low early mortality and excellent durability at shor …
An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro.
Haber M, Norris MD, Kavallaris M, Camacho M, Madafiglio J, Baker CJ, White L, Stewart BW. Haber M, et al. Among authors: norris md. Cancer Lett. 1995 Oct 20;97(1):49-55. doi: 10.1016/0304-3835(95)03950-2. Cancer Lett. 1995. PMID: 7585477
When accumulation of MTX by such cell populations was expressed, however, relative to their accumulation of thymidine, MTX accumulation was shown to be equal to that of drug-sensitive CCRF-CEM cells maintained in long-term culture. In contrast, significantly less MTX was a …
When accumulation of MTX by such cell populations was expressed, however, relative to their accumulation of thymidine, MTX accumulation was …
Therapy-induced drug resistance in a human leukemia line (LALW-2). A clinically relevant model.
White L, Haber M, Brian MJ, Norris MD, Trickett A, Sosula L, Tiley C, Stewart BW. White L, et al. Among authors: norris md. Cancer. 1989 Jun 1;63(11):2103-10. doi: 10.1002/1097-0142(19890601)63:11<2103::aid-cncr2820631106>3.0.co;2-n. Cancer. 1989. PMID: 2720561
The growth rate of LALW-2 xenografts was differentially affected by drugs administered to host mice, the cells being resistant to cytotoxic agents (particularly methotrexate and doxorubicin) used in treatment of the donor patient. In short-term in vitro culture, LALW-2 cel …
The growth rate of LALW-2 xenografts was differentially affected by drugs administered to host mice, the cells being resistant to cytotoxic …