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Posttranscriptional regulation of neurofilament proteins and tau in health and disease.
Yuan A, Nixon RA. Yuan A, et al. Among authors: nixon ra. Brain Res Bull. 2023 Jan;192:115-127. doi: 10.1016/j.brainresbull.2022.10.017. Epub 2022 Oct 29. Brain Res Bull. 2023. PMID: 36441047 Free PMC article. Review.
Both proteins share functions related to the modulation of stability and functions of the microtubule network in axons, axonal transport and scaffolding of organelles, long-term synaptic potentiation, and learning and memory. Expression of these proteins is regulated not o …
Both proteins share functions related to the modulation of stability and functions of the microtubule network in axons, axonal transport and …
Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors.
Yuan A, Veeranna, Sershen H, Basavarajappa BS, Smiley JF, Hashim A, Bleiwas C, Berg M, Guifoyle DN, Subbanna S, Darji S, Kumar A, Rao MV, Wilson DA, Julien JP, Javitt DC, Nixon RA. Yuan A, et al. Among authors: nixon ra. Transl Psychiatry. 2018 Aug 24;8(1):167. doi: 10.1038/s41398-018-0194-7. Transl Psychiatry. 2018. PMID: 30143609 Free PMC article.
NFL-/- deletion in mice reduces dendritic spines and GluN1 protein levels, elevates ubiquitin-dependent turnover of GluN1 and hippocampal glutamate measured by MRS, and depresses hippocampal long-term potentiation. NMDAR-related behaviors are also impaired, including pup r …
NFL-/- deletion in mice reduces dendritic spines and GluN1 protein levels, elevates ubiquitin-dependent turnover of GluN1 and hippocampal gl …
Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo.
Yuan A, Sershen H, Veeranna, Basavarajappa BS, Kumar A, Hashim A, Berg M, Lee JH, Sato Y, Rao MV, Mohan PS, Dyakin V, Julien JP, Lee VM, Nixon RA. Yuan A, et al. Among authors: nixon ra. Mol Psychiatry. 2015 Aug;20(8):986-94. doi: 10.1038/mp.2015.45. Epub 2015 Apr 14. Mol Psychiatry. 2015. PMID: 25869803 Free PMC article.
Completely eliminating NF proteins from brain by genetically deleting three subunits (alpha-internexin, NFH and NFL) markedly depresses hippocampal long-term potentiation induction without detectably altering synapse morphology. ...
Completely eliminating NF proteins from brain by genetically deleting three subunits (alpha-internexin, NFH and NFL) markedly depresses hipp …
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
Alzheimer's Association National Plan Milestone Workgroup; Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC. Alzheimer's Association National Plan Milestone Workgroup, et al. Among authors: nixon ra. Alzheimers Dement. 2014 Oct;10(5 Suppl):S430-52. doi: 10.1016/j.jalz.2014.08.103. Alzheimers Dement. 2014. PMID: 25341459 Free article.
To guide investments, activities, and the measurement of progress toward achieving this 2025 goal, in its first annual plan update (2013) HHS also incorporated into the plan a set of short, medium and long-term milestones. HHS further committed to updating these milestones …
To guide investments, activities, and the measurement of progress toward achieving this 2025 goal, in its first annual plan update (2013) HH …
Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.
Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC. Menzies FM, et al. Among authors: nixon ra. Cell Death Differ. 2015 Mar;22(3):433-44. doi: 10.1038/cdd.2014.151. Epub 2014 Sep 26. Cell Death Differ. 2015. PMID: 25257175 Free PMC article.
Furthermore, we demonstrate that, overexpression of the calpain inhibitor, calpastatin, increases autophagosome levels and is protective in a mouse model of Huntington's disease, improving motor signs and delaying the onset of tremors. Importantly, long-term inhibition of …
Furthermore, we demonstrate that, overexpression of the calpain inhibitor, calpastatin, increases autophagosome levels and is protective in …
Workgroup on NAPA's scientific agenda for a national initiative on Alzheimer's disease.
Alzheimer's Association Expert Advisory Workgroup on NAPA. Alzheimer's Association Expert Advisory Workgroup on NAPA. Alzheimers Dement. 2012 Jul;8(4):357-71. doi: 10.1016/j.jalz.2012.04.003. Alzheimers Dement. 2012. PMID: 22748940
The primary public policy aims of this 10-year scientific agenda are to discover, validate, and develop: (1) a broad range of technologies, tools and algorithms for early detection of people with symptomatic AD, and asymptomatic individuals at elevated risk for AD and other demen …
The primary public policy aims of this 10-year scientific agenda are to discover, validate, and develop: (1) a broad range of technologies, …
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.
Ginsberg SD, Alldred MJ, Counts SE, Cataldo AM, Neve RL, Jiang Y, Wuu J, Chao MV, Mufson EJ, Nixon RA, Che S. Ginsberg SD, et al. Among authors: nixon ra. Biol Psychiatry. 2010 Nov 15;68(10):885-93. doi: 10.1016/j.biopsych.2010.05.030. Epub 2010 Jul 23. Biol Psychiatry. 2010. PMID: 20655510 Free PMC article.
Increased endocytic pathway activity, driven by elevated rab GTPase expression, may result in long-term deficits in hippocampal neurotrophic signaling and represent a key pathogenic mechanism underlying AD progression....
Increased endocytic pathway activity, driven by elevated rab GTPase expression, may result in long-term deficits in hippocampal neuro …
Cortical plasticity in Alzheimer's disease in humans and rodents.
Battaglia F, Wang HY, Ghilardi MF, Gashi E, Quartarone A, Friedman E, Nixon RA. Battaglia F, et al. Among authors: nixon ra. Biol Psychiatry. 2007 Dec 15;62(12):1405-12. doi: 10.1016/j.biopsych.2007.02.027. Epub 2007 Jul 25. Biol Psychiatry. 2007. PMID: 17651702
BACKGROUND: The aim of this study was to determine whether neocortical long-term potentiation (LTP) is deficient in patients with Alzheimer's disease (AD) and in amyloid precursor protein (APP)/presenilin-1 (PS1) mice, an AD animal model. ...
BACKGROUND: The aim of this study was to determine whether neocortical long-term potentiation (LTP) is deficient in patients with Alz …
Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death.
Adamec E, Beermann ML, Nixon RA. Adamec E, et al. Among authors: nixon ra. Brain Res Mol Brain Res. 1998 Feb;54(1):35-48. doi: 10.1016/s0169-328x(97)00304-5. Brain Res Mol Brain Res. 1998. PMID: 9526039
Additionally, the presence of calpain inhibitors was detrimental to the clearance of neuritic varicosities resulting from a short-term sublethal exposure to glutamate, suggesting that a physiological level of calpain I activation might actually play an important homeostati …
Additionally, the presence of calpain inhibitors was detrimental to the clearance of neuritic varicosities resulting from a short-term …
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