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A single-institutional experience with 36 children less than 5 kilograms supported with the Berlin Heart: Comparison of congenital versus acquired heart disease.
Bleiweis MS, Sharaf OM, Philip J, Peek GJ, Stukov Y, Janelle GM, Pitkin AD, Sullivan KJ, Nixon CS, Neal D, Jacobs JP. Bleiweis MS, et al. Among authors: nixon cs. Cardiol Young. 2024 Feb 16:1-8. doi: 10.1017/S1047951123004134. Online ahead of print. Cardiol Young. 2024. PMID: 38362907
The Kaplan-Meier method and log-rank tests were used to assess group differences in long-term survival after ventricular assist device insertion. T-tests using estimated survival proportions were used to compare groups at specific time points. ...
The Kaplan-Meier method and log-rank tests were used to assess group differences in long-term survival after ventricular assist devic …
Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases.
Wood CS, Pennel KAF, Leslie H, Legrini A, Cameron AJ, Melissourgou-Syka L, Quinn JA, van Wyk HC, Hay J, Roseweir AK, Nixon C, Roxburgh CSD, McMillan DC, Biankin AV, Sansom OJ, Horgan PG, Edwards J, Steele CW, Jamieson NB. Wood CS, et al. Among authors: nixon c. Cancer Res. 2023 Apr 14;83(8):1329-1344. doi: 10.1158/0008-5472.CAN-22-2794. Cancer Res. 2023. PMID: 37057593 Free PMC article.
Bulk transcriptomic analysis was confounded by stromal content, but ST demonstrated that the invasive edge of the metastases of long-term survivors was characterized by adaptive immune cell populations enriched for type II IFN signaling and MHC-class II antigen presentatio …
Bulk transcriptomic analysis was confounded by stromal content, but ST demonstrated that the invasive edge of the metastases of long-term …
A Single-Institutional Experience with 36 Children Smaller Than 5 Kilograms Supported with the Berlin Heart Ventricular Assist Device (VAD) over 12 Years: Comparison of Patients with Biventricular versus Functionally Univentricular Circulation.
Bleiweis MS, Philip J, Peek GJ, Stukov Y, Janelle GM, Pitkin AD, Sullivan KJ, Nixon CS, Sharaf OM, Neal D, Jacobs JP. Bleiweis MS, et al. Among authors: nixon cs. World J Pediatr Congenit Heart Surg. 2023 Mar;14(2):117-124. doi: 10.1177/21501351221146150. Epub 2023 Feb 16. World J Pediatr Congenit Heart Surg. 2023. PMID: 36798022 Review.
Kaplan-Meier methods and log-rank tests were used to assess group differences in long-term survival after VAD insertion. T-tests using estimated survival proportions and standard errors were used to compare groups at specific time points. ...
Kaplan-Meier methods and log-rank tests were used to assess group differences in long-term survival after VAD insertion. T-tests usin …
First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.
Beckford-Vera DR, Flavell RR, Seo Y, Martinez-Ortiz E, Aslam M, Thanh C, Fehrman E, Pardons M, Kumar S, Deitchman AN, Ravanfar V, Schulte B, Wu IK, Pan T, Reeves JD, Nixon CC, Iyer NS, Torres L, Munter SE, Hyunh T, Petropoulos CJ, Hoh R, Franc BL, Gama L, Koup RA, Mascola JR, Chomont N, Deeks SG, VanBrocklin HF, Henrich TJ. Beckford-Vera DR, et al. Among authors: nixon cc. Nat Commun. 2022 Mar 9;13(1):1219. doi: 10.1038/s41467-022-28727-5. Nat Commun. 2022. PMID: 35264559 Free PMC article.
A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure of HIV infection is the presence of persistently infected cells that establish a long-lived viral reservoir. ...
A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure of HIV infection is the presence of pe …
Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice.
Kiourtis C, Wilczynska A, Nixon C, Clark W, May S, Bird TG. Kiourtis C, et al. Among authors: nixon c. Biol Open. 2021 Sep 15;10(9):bio058678. doi: 10.1242/bio.058678. Epub 2021 Sep 22. Biol Open. 2021. PMID: 34435198 Free PMC article.
However, their off-target effects in mice have not been thoroughly explored. Here, we sought to identify the short-term off-target effects of AAV8 administration in mice. To do this, we injected C57BL/6J wild-type mice with either recombinant AAV8 vectors expressing Cre re …
However, their off-target effects in mice have not been thoroughly explored. Here, we sought to identify the short-term off-target ef …
Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms.
Peluso MJ, Deitchman AN, Torres L, Iyer NS, Munter SE, Nixon CC, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman EA, Spinelli MA, Gandhi M, Trinh L, Wrin T, Petropoulos CJ, Aweeka FT, Rodriguez-Barraquer I, Kelly JD, Martin JN, Deeks SG, Greenhouse B, Rutishauser RL, Henrich TJ. Peluso MJ, et al. Among authors: nixon cc. Cell Rep. 2021 Aug 10;36(6):109518. doi: 10.1016/j.celrep.2021.109518. Epub 2021 Aug 6. Cell Rep. 2021. PMID: 34358460 Free PMC article.
Whereas the magnitude of early CD4(+) T cell immune responses correlates with severity of initial infection, pre-existing lung disease is independently associated with higher long-term SARS-CoV-2-specific CD8(+) T cell responses. Among participants with PASC 4 months follo …
Whereas the magnitude of early CD4(+) T cell immune responses correlates with severity of initial infection, pre-existing lung disease is in …
Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19.
Peluso MJ, Deitchman AN, Torres L, Iyer NS, Nixon CC, Munter SE, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman E, Spinelli MA, Gandhi M, Trinh L, Wrin T, Petropoulos CJ, Aweeka FT, Rodriguez-Barraquer I, Kelly JD, Martin JN, Deeks SG, Greenhouse B, Rutishauser RL, Henrich TJ. Peluso MJ, et al. Among authors: nixon cc. medRxiv [Preprint]. 2021 Mar 1:2021.02.26.21252308. doi: 10.1101/2021.02.26.21252308. medRxiv. 2021. PMID: 33688685 Free PMC article. Updated. Preprint.
A detailed understanding of long-term SARS-CoV-2-specific T cell responses and their relationship to humoral immunity and markers of inflammation in diverse groups of individuals representing the spectrum of COVID-19 illness and recovery is urgently needed. ...Importantly, …
A detailed understanding of long-term SARS-CoV-2-specific T cell responses and their relationship to humoral immunity and markers of …
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations.
Sun B, Tang N, Peluso MJ, Iyer NS, Torres L, Donatelli JL, Munter SE, Nixon CC, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Pulliam L. Sun B, et al. Among authors: nixon cc. Cells. 2021 Feb 13;10(2):386. doi: 10.3390/cells10020386. Cells. 2021. PMID: 33668514 Free PMC article.
As the SARS-CoV-2 pandemic continues, reports have demonstrated neurologic sequelae following COVID-19 recovery. Mechanisms to explain long-term neurological sequelae are unknown and need to be identified. ...
As the SARS-CoV-2 pandemic continues, reports have demonstrated neurologic sequelae following COVID-19 recovery. Mechanisms to explain long- …
Trial of healthy relationship initiatives for the very early years (THRIVE), evaluating Enhanced Triple P for Baby and Mellow Bumps additional social and care needs during pregnancy and their infants who are at higher risk of maltreatment: study protocol for a randomised controlled trial.
Henderson M, Wittkowski A, McIntosh E, McConnachie A, Buston K, Wilson P, Calam R, Minnis H, Thompson L, O'Dowd J, Law J, McGee E, Wight D; THRIVE Trial Research Team. Henderson M, et al. Trials. 2019 Aug 14;20(1):499. doi: 10.1186/s13063-019-3571-5. Trials. 2019. PMID: 31412902 Free PMC article.
As both interventions aim to improve maternal mental health and parenting skills, we hypothesise that in the longer term, participation may lead to an improvement in children's life trajectories. ...
As both interventions aim to improve maternal mental health and parenting skills, we hypothesise that in the longer term, participati …
Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas.
Forconi CS, Cosgrove CP, Saikumar-Lakshmi P, Nixon CE, Foley J, Ong'echa JM, Otieno JA, Alter G, Münz C, Moormann AM. Forconi CS, et al. Among authors: nixon ce. Blood Adv. 2018 May 22;2(10):1101-1114. doi: 10.1182/bloodadvances.2017015404. Blood Adv. 2018. PMID: 29764843 Free PMC article.
Of note, the accumulation of poorly cytotoxic CD56(neg)CD16(pos) NK cells resolved in long-term eBL survivors. Our study demonstrates impaired NK cell-mediated immunosurveillance in eBL patients but with the potential to restore a protective NK cell repertoire after cancer …
Of note, the accumulation of poorly cytotoxic CD56(neg)CD16(pos) NK cells resolved in long-term eBL survivors. Our study demonstrates …
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