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Contrast enhanced endoscopic ultrasound detects early therapy response following anti-TNF-therapy in patients with ulcerative colitis.
Ellrichmann M, Schulte B, Conrad CC, Schoch S, Bethge J, Seeger M, Huber R, Goeb M, Arlt A, Nikolaus S, Röcken C, Schreiber S. Ellrichmann M, et al. Among authors: nikolaus s. J Crohns Colitis. 2024 Mar 8:jjae034. doi: 10.1093/ecco-jcc/jjae034. Online ahead of print. J Crohns Colitis. 2024. PMID: 38457414
CONCLUSION: dCEUS enables the early detection of therapy response in patients with aUC, which serves as a predictive marker for long term clinical success. Therefore, dCEUS serves as a diagnostic tool for assessing the probability of future therapy success....
CONCLUSION: dCEUS enables the early detection of therapy response in patients with aUC, which serves as a predictive marker for long term …
I-CARE, a European Prospective Cohort Study Assessing Safety and Effectiveness of Biologics in Inflammatory Bowel Disease.
Peyrin-Biroulet L, Rahier JF, Kirchgesner J, Abitbol V, Shaji S, Armuzzi A, Karmiris K, Gisbert JP, Bossuyt P, Helwig U, Burisch J, Yanai H, Doherty GA, Magro F, Molnar T, Löwenberg M, Halfvarson J, Zagorowicz E, Rousseau H, Baumann C, Baert F, Beaugerie L; I-CARE Collaborator Group. Peyrin-Biroulet L, et al. Clin Gastroenterol Hepatol. 2023 Mar;21(3):771-788.e10. doi: 10.1016/j.cgh.2022.09.018. Epub 2022 Sep 22. Clin Gastroenterol Hepatol. 2023. PMID: 36152897 Free article.
CONCLUSIONS: I-CARE is an ongoing investigator-initiated observational European prospective cohort study that will provide unique information on the long-term benefits and risks of biological therapies in IBD patients. ...
CONCLUSIONS: I-CARE is an ongoing investigator-initiated observational European prospective cohort study that will provide unique informatio …
Longitudinal monitoring of STAT3 phosphorylation and histologic outcome of tofacitinib therapy in patients with ulcerative colitis.
Verstockt B, Volk V, Jaeckel C, Alsoud D, Sabino J, Nikolaus S, Outtier A, Krönke N, Feuerhake F, De Hertogh G, Rosenstiel P, Vermeire S, Schreiber S, Ferrante M, Aden K. Verstockt B, et al. Among authors: nikolaus s. Aliment Pharmacol Ther. 2022 Jul;56(2):282-291. doi: 10.1111/apt.16955. Epub 2022 Apr 28. Aliment Pharmacol Ther. 2022. PMID: 35484689

Endoscopic improvement at week 8 was significantly associated with treatment continuation in the long-term (72.7% vs 20.6%, p = 0.003). Although we observed a gradual decrease of mucosal pSTAT3 levels in both remitters and non-remitters (p < 0.05), no association with t

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Endoscopic improvement at week 8 was significantly associated with treatment continuation in the long-term (72.7% vs 20.6%, p = 0.003 …
Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies.
Geisen UM, Sümbül M, Tran F, Berner DK, Reid HM, Vullriede L, Ciripoi M, Longardt AC, Hoff P, Morrison PJ, Schneider VE, Zeuner R, Schirmer JH, Steinbach A, Nikolaus S, Gerdes S, Schreiber S, Bacher P, Hoyer BF. Geisen UM, et al. Among authors: nikolaus s. RMD Open. 2021 Dec;7(3):e002008. doi: 10.1136/rmdopen-2021-002008. RMD Open. 2021. PMID: 34880128 Free PMC article.
No differences in SARS-CoV2 spike-specific CD4+ T-cell frequencies were detected. CONCLUSION: Although the long-term efficacy of SARS-CoV2 vaccination in CID patients undergoing disease-modifying therapy is still not known, the pronounced declines in humoral responses towa …
No differences in SARS-CoV2 spike-specific CD4+ T-cell frequencies were detected. CONCLUSION: Although the long-term efficacy of SARS …
Implementation of stepped care for patients with chronic fatigue syndrome in community-based mental health care: outcomes at post-treatment and long-term follow-up.
Janse A, van Dam A, Pijpers C, Wiborg JF, Bleijenberg G, Tummers M, Twisk J, Nikolaus S, Knoop H. Janse A, et al. Among authors: nikolaus s. Behav Cogn Psychother. 2019 Sep;47(5):548-558. doi: 10.1017/S1352465819000110. Epub 2019 Mar 12. Behav Cogn Psychother. 2019. PMID: 30859928 Clinical Trial.
AIMS: (1) To test the effectiveness of stepped care for CFS implemented in a MHC at post-treatment and at long-term follow-up; and (2) compare post-treatment outcomes of implemented stepped care with treatment outcomes of a CFS specialist centre. ...CONCLUSION: Implemented …
AIMS: (1) To test the effectiveness of stepped care for CFS implemented in a MHC at post-treatment and at long-term follow-up; and (2 …
Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.
Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C. Wichert R, et al. Among authors: nikolaus s. Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087. Cell Rep. 2017. PMID: 29166602 Free article.
Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene.
Wang AL, Fazari B, Chao OY, Nikolaus S, Trossbach SV, Korth C, Sialana FJ, Lubec G, Huston JP, Mattern C, de Souza Silva MA. Wang AL, et al. Among authors: nikolaus s. Neurobiol Learn Mem. 2017 Dec;146:12-20. doi: 10.1016/j.nlm.2017.10.015. Epub 2017 Oct 28. Neurobiol Learn Mem. 2017. PMID: 29107702
To ascertain whether the DISC1 gene also impacts cognitive functions, 14-15 months old male tgDISC1 rats and wild-type controls were subjected to the novel object preference (NOP) test and the object-based attention test (OBAT) in order to assess short-term memory (1 h), l …
To ascertain whether the DISC1 gene also impacts cognitive functions, 14-15 months old male tgDISC1 rats and wild-type controls were subject …
Long-term follow-up after cognitive behaviour therapy for chronic fatigue syndrome.
Janse A, Nikolaus S, Wiborg JF, Heins M, van der Meer JWM, Bleijenberg G, Tummers M, Twisk J, Knoop H. Janse A, et al. Among authors: nikolaus s. J Psychosom Res. 2017 Jun;97:45-51. doi: 10.1016/j.jpsychores.2017.03.016. Epub 2017 Mar 27. J Psychosom Res. 2017. PMID: 28606498
METHODS: Participants (n=583) of previously published studies on the effects of CBT for CFS were contacted for a long-term follow-up assessment. They completed questionnaires on main outcomes fatigue severity (CIS) and physical functioning (SF-36). ...CONCLUSION: Positive …
METHODS: Participants (n=583) of previously published studies on the effects of CBT for CFS were contacted for a long-term follow-up …
Promnestic effects of intranasally applied pregnenolone in rats.
Abdel-Hafiz L, Chao OY, Huston JP, Nikolaus S, Spieler RE, de Souza Silva MA, Mattern C. Abdel-Hafiz L, et al. Among authors: nikolaus s. Neurobiol Learn Mem. 2016 Sep;133:185-195. doi: 10.1016/j.nlm.2016.07.012. Epub 2016 Jul 14. Neurobiol Learn Mem. 2016. PMID: 27423520
The main findings were: (a) Pre-trial, but not post-trial, administration of IN-PREG facilitated long-term memory in a novel object-preference test and a novel object-location preference test when tested 48h after dosing. ...
The main findings were: (a) Pre-trial, but not post-trial, administration of IN-PREG facilitated long-term memory in a novel object-p …
Investigating the dopaminergic synapse in vivo. II. Molecular imaging studies in small laboratory animals.
Nikolaus S, Larisch R, Beu M, Antke C, Kley K, Forutan F, Wirrwar A, Müller HW. Nikolaus S, et al. Rev Neurosci. 2007;18(6):473-504. doi: 10.1515/revneuro.2007.18.6.473. Rev Neurosci. 2007. PMID: 18330213 Review.
The performance of animal studies allows the induction of specific short-term or long-term synaptic conditions via pharmacological challenges or infliction of neurotoxic lesions. ...Findings also showed that chronic application of cocaine induced long-term re …
The performance of animal studies allows the induction of specific short-term or long-term synaptic conditions via pharmacolog …
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