Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.
Kumar A, Aglyamova G, Yim YY, Bailey AO, Lynch HM, Powell RT, Nguyen ND, Rosenthal Z, Zhao WN, Li Y, Chen J, Fan S, Lee H, Russell WK, Stephan C, Robison AJ, Haggarty SJ, Nestler EJ, Zhou J, Machius M, Rudenko G.
Kumar A, et al. Among authors: nguyen nd.
Nucleic Acids Res. 2022 Sep 9;50(16):9548-9567. doi: 10.1093/nar/gkac710.
Nucleic Acids Res. 2022.
PMID: 36039764
Free PMC article.
The AP1 transcription factor deltaFOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults such as exposure to drugs of abuse, depression, Alzheimer's disease and tardive dyskinesias, and mediates subsequent long-term neuroadaptations. deltaF …
The AP1 transcription factor deltaFOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults such as exposure t …