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A Bright, Nontoxic, and Non-aggregating red Fluorescent Protein for Long-Term Labeling of Fine Structures in Neurons.
Ning L, Geng Y, Lovett-Barron M, Niu X, Deng M, Wang L, Ataie N, Sens A, Ng HL, Chen S, Deisseroth K, Lin MZ, Chu J. Ning L, et al. Among authors: ng hl. Front Cell Dev Biol. 2022 Jun 29;10:893468. doi: 10.3389/fcell.2022.893468. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35846353 Free PMC article.
We report the engineering of a bright red fluorescent protein, Crimson, that enables long-term morphological labeling of neurons without aggregation or toxicity. ...
We report the engineering of a bright red fluorescent protein, Crimson, that enables long-term morphological labeling of neurons with …
Longitudinal Healthcare Utilization and Costs in Parkinson's Disease: Pre-Diagnosis to 9 Years After.
Soh EML, Neo S, Saffari SE, Wong ASY, Ganesan G, Li W, Ng HL, Xu Z, Tay KY, Au WL, Tan KB, Tan LCS. Soh EML, et al. Among authors: ng hl. J Parkinsons Dis. 2022;12(3):957-966. doi: 10.3233/JPD-212982. J Parkinsons Dis. 2022. PMID: 34974439
BACKGROUND: There is currently insufficient long-term data on costs of treatment in patients with Parkinson's disease (PD), which is chronic and progressive, and associated with substantial healthcare costs. Identifying patterns in healthcare utilization and cost may illum …
BACKGROUND: There is currently insufficient long-term data on costs of treatment in patients with Parkinson's disease (PD), which is …
Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones.
Balamurugan A, Ng HL, Yang OO. Balamurugan A, et al. Among authors: ng hl. J Virol. 2018 Jul 31;92(16):e00617-18. doi: 10.1128/JVI.00617-18. Print 2018 Aug 15. J Virol. 2018. PMID: 29899094 Free PMC article.
While these are low-avidity interactions that do not appear to contribute directly to the antiviral activity of CTLs, this raises interesting biologic implications regarding the purpose of the phenomenon, such as providing a stimulus for these responses to persist long term …
While these are low-avidity interactions that do not appear to contribute directly to the antiviral activity of CTLs, this raises interestin …
Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence.
Forest KH, Alfulaij N, Arora K, Taketa R, Sherrin T, Todorovic C, Lawrence JLM, Yoshikawa GT, Ng HL, Hruby VJ, Nichols RA. Forest KH, et al. Among authors: ng hl. J Neurochem. 2018 Jan;144(2):201-217. doi: 10.1111/jnc.14257. Epub 2017 Dec 18. J Neurochem. 2018. PMID: 29164616 Free article.
An N-terminal Abeta fragment (1-15/16), found in cerebrospinal fluid, was also shown to be a highly active neuromodulator and to reverse Abeta-induced impairments of long-term potentiation. Here, we show the impact of this N-terminal Abeta fragment and a shorter hexapeptid …
An N-terminal Abeta fragment (1-15/16), found in cerebrospinal fluid, was also shown to be a highly active neuromodulator and to reverse Abe …
Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.
Brennan CA, Ibarrondo FJ, Sugar CA, Hausner MA, Shih R, Ng HL, Detels R, Margolick JB, Rinaldo CR, Phair J, Jacobson LP, Yang OO, Jamieson BD. Brennan CA, et al. Among authors: ng hl. J Virol. 2012 Oct;86(19):10505-16. doi: 10.1128/JVI.00102-12. Epub 2012 Jul 18. J Virol. 2012. PMID: 22811521 Free PMC article.
Although CTL responses in the early months of infection are likely to be the most important for the long-term rate of HIV-1 disease progression, few data on the early CTL responses of eventual slow progressors have been available. ...
Although CTL responses in the early months of infection are likely to be the most important for the long-term rate of HIV-1 disease p …
Increasing CTL targeting of conserved sequences during early HIV-1 infection is correlated to decreasing viremia.
Yang OO, Daar ES, Ng HL, Shih R, Jamieson BD. Yang OO, et al. Among authors: ng hl. AIDS Res Hum Retroviruses. 2011 Apr;27(4):391-8. doi: 10.1089/aid.2010.0183. Epub 2010 Nov 18. AIDS Res Hum Retroviruses. 2011. PMID: 21087140 Free PMC article.
Circumventing this natural history by pre-targeting CTL against more conserved epitopes with a vaccine could minimize the initial period of viral escape and immune damage during acute infection, improving long-term containment of HIV-1....
Circumventing this natural history by pre-targeting CTL against more conserved epitopes with a vaccine could minimize the initial period of …
Grouping in short-term memory: do oscillators code the positions of items?
Ng HL, Maybery MT. Ng HL, et al. J Exp Psychol Learn Mem Cogn. 2005 Jan;31(1):175-81. doi: 10.1037/0278-7393.31.1.175. J Exp Psychol Learn Mem Cogn. 2005. PMID: 15641915
According to several current models of short-term memory, items are retained in order by associating them with positional codes. ...
According to several current models of short-term memory, items are retained in order by associating them with positional codes. ...
Grouping in short-term verbal memory: is position coded temporally?
Ng HL, Maybery MT. Ng HL, et al. Q J Exp Psychol A. 2002 Apr;55(2):391-424. doi: 10.1080/02724980143000343. Q J Exp Psychol A. 2002. PMID: 12047051
The nature of the mechanisms that code item position in serial short-term verbal recall was investigated with reference to temporal grouping phenomena--effects that arise when additional pauses are inserted in a presented list to form groups of items. ...
The nature of the mechanisms that code item position in serial short-term verbal recall was investigated with reference to temporal g …