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Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism.
Liu Y, Kuang A, Bain JR, Muehlbauer MJ, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Liu Y, et al. Among authors: newgard cb. J Clin Endocrinol Metab. 2021 Oct 21;106(11):3283-3294. doi: 10.1210/clinem/dgab513. J Clin Endocrinol Metab. 2021. PMID: 34255031 Free PMC article.
CONTEXT: Gestational diabetes is associated with a long-term risk of developing a disorder of glucose metabolism. However, neither the metabolic changes characteristic of gestational diabetes in a large, multi-ancestry cohort nor the ability of metabolic changes during pre …
CONTEXT: Gestational diabetes is associated with a long-term risk of developing a disorder of glucose metabolism. However, neither th …
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.
White PJ, McGarrah RW, Herman MA, Bain JR, Shah SH, Newgard CB. White PJ, et al. Among authors: newgard cb. Mol Metab. 2021 Oct;52:101261. doi: 10.1016/j.molmet.2021.101261. Epub 2021 May 24. Mol Metab. 2021. PMID: 34044180 Free PMC article. Review.
Lowering of BCAA and branched-chain ketoacid (BCKA) levels by feeding BCAA-restricted diet or by the activation of the rate-limiting enzyme in BCAA catabolism, branched-chain ketoacid dehydrogenase (BCKDH), in rodent models of obesity have clear salutary effects on glucose and li …
Lowering of BCAA and branched-chain ketoacid (BCKA) levels by feeding BCAA-restricted diet or by the activation of the rate-limiting enzyme …
Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
Hohmeier HE, Zhang L, Taylor B, Stephens S, Lu D, McNamara P, Laffitte B, Newgard CB. Hohmeier HE, et al. Among authors: newgard cb. PLoS One. 2020 Mar 16;15(3):e0224344. doi: 10.1371/journal.pone.0224344. eCollection 2020. PLoS One. 2020. PMID: 32176701 Free PMC article.
Further studies of the most potent of these compounds, GNF-9228, revealed that it selectively activates human beta-cell relative to alpha-cell proliferation and has no effect on delta-cell replication. In addition, pre-treatment, but not short term exposure of human islets …
Further studies of the most potent of these compounds, GNF-9228, revealed that it selectively activates human beta-cell relative to alpha-ce …
Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure.
Younge NE, Newgard CB, Cotten CM, Goldberg RN, Muehlbauer MJ, Bain JR, Stevens RD, O'Connell TM, Rawls JF, Seed PC, Ashley PL. Younge NE, et al. Among authors: newgard cb. Sci Rep. 2019 Jun 3;9(1):8167. doi: 10.1038/s41598-019-44547-y. Sci Rep. 2019. PMID: 31160673 Free PMC article.
Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. ...
Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm in …
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.
Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Meyer JG, et al. Among authors: newgard cb. PLoS One. 2018 Dec 26;13(12):e0208973. doi: 10.1371/journal.pone.0208973. eCollection 2018. PLoS One. 2018. PMID: 30586434 Free PMC article.
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high-fat diet (HFD), with or without glucose or fructose supplementation, and quantified liver metabolites, 861 proteins, and 1,815 protein level …
To connect diet and molecular changes, here we performed short- and long-term feeding of mice with standard chow diet (SCD) and high- …
Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes.
Sandler V, Reisetter AC, Bain JR, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL Jr; HAPO Study Cooperative Research Group. Sandler V, et al. Among authors: newgard cb. Diabetologia. 2017 Mar;60(3):518-530. doi: 10.1007/s00125-016-4182-2. Epub 2016 Dec 16. Diabetologia. 2017. PMID: 27981358 Free PMC article.
AIMS/HYPOTHESIS: Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediated through the intrauterine environment. …
AIMS/HYPOTHESIS: Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are asso …
Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short-term high-fat overfeeding.
Ribel-Madsen A, Hellgren LI, Brøns C, Ribel-Madsen R, Newgard CB, Vaag AA. Ribel-Madsen A, et al. Among authors: newgard cb. Physiol Rep. 2016 Dec;4(23):e13044. doi: 10.14814/phy2.13044. Physiol Rep. 2016. PMID: 27956466 Free PMC article.
Low birth weight (LBW) individuals exhibit a disproportionately increased, incomplete fatty acid oxidation and a decreased glucose oxidation, compared with normal birth weight (NBW) individuals, and furthermore have an increased risk of developing insulin resistance …
Low birth weight (LBW) individuals exhibit a disproportionately increased, incomplete fatty acid oxidation and a decreased glucose ox …
Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model.
Masko EM, Alfaqih MA, Solomon KR, Barry WT, Newgard CB, Muehlbauer MJ, Valilis NA, Phillips TE, Poulton SH, Freedland AR, Sun S, Dambal SK, Sanders SE, Macias E, Freeman MR, Dewhirst MW, Pizzo SV, Freedland SJ. Masko EM, et al. Among authors: newgard cb. Prostate. 2017 Apr;77(5):446-457. doi: 10.1002/pros.23282. Epub 2016 Nov 30. Prostate. 2017. PMID: 27900797 Free PMC article.
We used a generalized linear model with the predictor variables of treatment, time, and treatment by time (i.e., interaction term) with tumor volume as the outcome variable. Total serum and tumor cholesterol were measured. ...
We used a generalized linear model with the predictor variables of treatment, time, and treatment by time (i.e., interaction term) wi …
Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.
Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C. Shin AC, et al. Among authors: newgard cb. Cell Metab. 2014 Nov 4;20(5):898-909. doi: 10.1016/j.cmet.2014.09.003. Epub 2014 Oct 9. Cell Metab. 2014. PMID: 25307860 Free PMC article.
Selective induction of hypothalamic insulin signaling in rats and genetic modulation of brain insulin receptors in mice demonstrate that brain insulin signaling is a major regulator of BCAA metabolism by inducing hepatic BCKDH. Short-term overfeeding impairs the ability of …
Selective induction of hypothalamic insulin signaling in rats and genetic modulation of brain insulin receptors in mice demonstrate that bra …
19 results