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Prenatal exposure to diethylstilbestrol and long-term impact on the breast and reproductive tract in humans and mice.
Newbold RR. Newbold RR. J Dev Orig Health Dis. 2012 Apr;3(2):73-82. doi: 10.1017/S2040174411000754. J Dev Orig Health Dis. 2012. PMID: 25101917
The term 'developmental origins of health and disease' (DOHaD) originally referred to delayed effects of altered maternal factors (e.g. smoking or poor nutrition) on the developing offspring, but it now also encompasses early life exposure to environmental chemicals, which …
The term 'developmental origins of health and disease' (DOHaD) originally referred to delayed effects of altered maternal factors (e. …
Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life.
Newbold RR, Jefferson WN, Padilla-Banks E. Newbold RR, et al. Environ Health Perspect. 2009 Jun;117(6):879-85. doi: 10.1289/ehp.0800045. Epub 2009 Jan 15. Environ Health Perspect. 2009. PMID: 19590677 Free PMC article.
OBJECTIVES: In this study we investigated whether prenatal BPA causes long-term adverse effects in female reproductive tissues in an experimental animal model previously shown useful in studying effects of prenatal DES. ...We did not observe these lesions in controls. CONC …
OBJECTIVES: In this study we investigated whether prenatal BPA causes long-term adverse effects in female reproductive tissues in an …
NTP toxicity report of reproductive dose range-finding study of Genistein (CAS No. 446-72-0) administered in feed to Sprague-Dawley rats.
Delclos KB, Newbold R. Delclos KB, et al. Among authors: newbold r. Toxic Rep Ser. 2007 Nov;(79):1-C2. Toxic Rep Ser. 2007. PMID: 18685712 Free article.
A significant exposure concentration-related effect on litter birth weight was observed, but no exposed group differed significantly from the control group in pairwise comparisons. ...In particular, the long-term consequences of low dose exposures that may produce s …
A significant exposure concentration-related effect on litter birth weight was observed, but no exposed group differed significantly …
Effects of endocrine disruptors on obesity.
Newbold RR, Padilla-Banks E, Jefferson WN, Heindel JJ. Newbold RR, et al. Int J Androl. 2008 Apr;31(2):201-8. doi: 10.1111/j.1365-2605.2007.00858.x. Int J Androl. 2008. PMID: 18315718 Review.
Together, these data suggest new targets (i.e. adipocyte differentiation and mechanisms involved in weight homeostasis) of abnormal programming by EDCs, and provide evidence that support the scientific term 'the developmental origins of adult disease'. The emerging idea of …
Together, these data suggest new targets (i.e. adipocyte differentiation and mechanisms involved in weight homeostasis) of abnormal programm …
Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract.
Newbold RR, Jefferson WN, Padilla-Banks E. Newbold RR, et al. Reprod Toxicol. 2007 Aug-Sep;24(2):253-8. doi: 10.1016/j.reprotox.2007.07.006. Epub 2007 Jul 27. Reprod Toxicol. 2007. PMID: 17804194 Free PMC article.
Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical with estrogenic activity used in the synthesis of plastics, we investigated its long-term effects in an experimental animal model th …
Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical …
Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations.
Newbold RR, Padilla-Banks E, Jefferson WN. Newbold RR, et al. Endocrinology. 2006 Jun;147(6 Suppl):S11-7. doi: 10.1210/en.2005-1164. Epub 2006 May 11. Endocrinology. 2006. PMID: 16690809 Review.
In humans and experimental animals, exposure to DES during critical periods of reproductive tract differentiation permanently alters estrogen target tissues and results in long-term abnormalities such as uterine neoplasia that are not manifested until later in life. ...Tog …
In humans and experimental animals, exposure to DES during critical periods of reproductive tract differentiation permanently alters estroge …
Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH.
Cabuy E, Newton C, Roberts T, Newbold R, Slijepcevic P. Cabuy E, et al. Among authors: newbold r. Cytometry A. 2004 Dec;62(2):150-61. doi: 10.1002/cyto.a.20096. Cytometry A. 2004. PMID: 15523603 Free article.
Differences in telomere length between subpopulations of cells were significant, and we term this phenomenon TELEFLUCS (TElomere LEngth FLUctuations in Cell Subpopulations). ...
Differences in telomere length between subpopulations of cells were significant, and we term this phenomenon TELEFLUCS (TElomere LEng …
Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effects.
Newbold RR, Jefferson WN, Padilla-Banks E, Haseman J. Newbold RR, et al. Reprod Toxicol. 2004 May;18(3):399-406. doi: 10.1016/j.reprotox.2004.01.007. Reprod Toxicol. 2004. PMID: 15082075
A similar dose-response curve was seen in 4 months old ovariectomized DES-treated mice suggesting the altered response was long-term. These data suggest xenoestrogen exposure during critical developmental windows alters hormone programming so that the uterus responds abnor …
A similar dose-response curve was seen in 4 months old ovariectomized DES-treated mice suggesting the altered response was long-term. …
Behavioral responses of rats exposed to long-term dietary vinclozolin.
Flynn KM, Delclos KB, Newbold RR, Ferguson SA. Flynn KM, et al. Among authors: newbold rr. J Agric Food Chem. 2001 Mar;49(3):1658-65. doi: 10.1021/jf0008893. J Agric Food Chem. 2001. PMID: 11312911
Gestational duration, total and live pups per litter, litter sex ratios, and birth weight were also not significantly affected, nor were body weight and food intake for dams and offspring. These results indicate that long-term dietary exposure to vinclozolin does no …
Gestational duration, total and live pups per litter, litter sex ratios, and birth weight were also not significantly affected, nor w …
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