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Long-term outcome of patients presenting with myocardial injury or myocardial infarction.
Haller PM, Kellner C, Sörensen NA, Lehmacher J, Toprak B, Schock A, Hartikainen TS, Twerenbold R, Zeller T, Westermann D, Neumann JT. Haller PM, et al. Among authors: neumann jt. Clin Res Cardiol. 2023 Nov 20. doi: 10.1007/s00392-023-02334-w. Online ahead of print. Clin Res Cardiol. 2023. PMID: 37982865
AIMS: Patients with acute or chronic myocardial injury are frequently identified in the context of suspected myocardial infarction (MI). We aimed to investigate their long-term follow-up. METHODS AND RESULTS: We prospectively enrolled 2714 patients with suspected MI and fo …
AIMS: Patients with acute or chronic myocardial injury are frequently identified in the context of suspected myocardial infarction (MI). We …
Diagnostic and prognostic value of the sex-specific 99th percentile of four high-sensitivity cardiac troponin assays in patients with suspected myocardial infarction.
Lehmacher J, Sörensen NA, Twerenbold R, Goßling A, Haller PM, Hartikainen TS, Schock A, Toprak B, Zeller T, Westermann D, Neumann JT. Lehmacher J, et al. Among authors: neumann jt. Eur Heart J Acute Cardiovasc Care. 2024 Feb 9;13(1):3-12. doi: 10.1093/ehjacc/zuad131. Eur Heart J Acute Cardiovasc Care. 2024. PMID: 37890108

Concentrations above 99th percentile were independent predictors for impaired long-term outcome (hazard ratios 1.2-1.5, P < 0.001). CONCLUSION: We describe a good diagnostic accuracy of four hs-cTn assays using the assay-specific 99th percentile for detection of MI. ...

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Concentrations above 99th percentile were independent predictors for impaired long-term outcome (hazard ratios 1.2-1.5, P < 0.001)

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Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.
Clemons GA, Silva ACE, Acosta CH, Udo MSB, Tesic V, Rodgers KM, Wu CY, Citadin CT, Lee RH, Neumann JT, Allani S, Prentice H, Zhang Q, Lin HW. Clemons GA, et al. Among authors: neumann jt. J Cell Physiol. 2022 Aug 29:10.1002/jcp.30858. doi: 10.1002/jcp.30858. Online ahead of print. J Cell Physiol. 2022. PMID: 36036549 Free PMC article.
Alzheimer's disease (AD) is the leading cause of mortality, disability, and long-term care burden in the United States, with women comprising the majority of AD diagnoses. ...
Alzheimer's disease (AD) is the leading cause of mortality, disability, and long-term care burden in the United States, with women co …
Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication.
Hussain SM, Ernst ME, Barker AL, Margolis KL, Reid CM, Neumann JT, Tonkin AM, Phuong TLT, Beilin LJ, Pham T, Chowdhury EK, Cicuttini FM, Gilmartin-Thomas JFM, Carr PR, McNeil JJ. Hussain SM, et al. Among authors: neumann jt. Hypertension. 2022 Sep;79(9):2051-2061. doi: 10.1161/HYPERTENSIONAHA.122.19356. Epub 2022 Jun 20. Hypertension. 2022. PMID: 35722878 Free PMC article.
Cox regression was used to calculate hazard ratio and 95% CI for associations with falls. RESULTS: Long-term variability in MAP was not associated with falls except amongst frail or prefrail participants using antihypertensive medications. Within this group each 5 mm Hg in …
Cox regression was used to calculate hazard ratio and 95% CI for associations with falls. RESULTS: Long-term variability in MAP was n …
Activation of Neuropeptide Y2 Receptor Can Inhibit Global Cerebral Ischemia-Induced Brain Injury.
Lee RH, Wu CY, Citadin CT, Couto E Silva A, Possoit HE, Clemons GA, Acosta CH, de la Llama VA, Neumann JT, Lin HW. Lee RH, et al. Among authors: neumann jt. Neuromolecular Med. 2022 Jun;24(2):97-112. doi: 10.1007/s12017-021-08665-z. Epub 2021 May 21. Neuromolecular Med. 2022. PMID: 34019239 Free PMC article.
Cardiopulmonary arrest (CA) can greatly impact a patient's life, causing long-term disability and death. Although multi-faceted treatment strategies against CA have improved survival rates, the prognosis of CA remains poor. ...
Cardiopulmonary arrest (CA) can greatly impact a patient's life, causing long-term disability and death. Although multi-faceted treat …
SC411 treatment can enhance survival in a mouse model of sickle cell disease.
Wu CYC, Lopez-Toledano MA, Daak AA, Clemons GA, Citadin CT, Sancilio FD, Rabinowicz AL, Minagar A, Neumann JT, Lee RHC, Lin HW. Wu CYC, et al. Among authors: neumann jt. Prostaglandins Leukot Essent Fatty Acids. 2020 Jul;158:102110. doi: 10.1016/j.plefa.2020.102110. Epub 2020 May 3. Prostaglandins Leukot Essent Fatty Acids. 2020. PMID: 32447175 Free article.
Application of High-Sensitivity Troponin in Suspected Myocardial Infarction.
Neumann JT, Twerenbold R, Ojeda F, Sörensen NA, Chapman AR, Shah ASV, Anand A, Boeddinghaus J, Nestelberger T, Badertscher P, Mokhtari A, Pickering JW, Troughton RW, Greenslade J, Parsonage W, Mueller-Hennessen M, Gori T, Jernberg T, Morris N, Liebetrau C, Hamm C, Katus HA, Münzel T, Landmesser U, Salomaa V, Iacoviello L, Ferrario MM, Giampaoli S, Kee F, Thorand B, Peters A, Borchini R, Jørgensen T, Söderberg S, Sans S, Tunstall-Pedoe H, Kuulasmaa K, Renné T, Lackner KJ, Worster A, Body R, Ekelund U, Kavsak PA, Keller T, Lindahl B, Wild P, Giannitsis E, Than M, Cullen LA, Mills NL, Mueller C, Zeller T, Westermann D, Blankenberg S; COMPASS-MI Study Group. Neumann JT, et al. N Engl J Med. 2019 Jun 27;380(26):2529-2540. doi: 10.1056/NEJMoa1803377. N Engl J Med. 2019. PMID: 31242362
Lower high-sensitivity troponin concentrations at presentation and smaller absolute changes during serial sampling were associated with a lower likelihood of myocardial infarction and a lower short-term risk of cardiovascular events. For example, high-sensitivity troponin …
Lower high-sensitivity troponin concentrations at presentation and smaller absolute changes during serial sampling were associated with a lo …
Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest.
Wu CYC, Lerner FM, Couto E Silva A, Possoit HE, Hsieh TH, Neumann JT, Minagar A, Lin HW, Lee RHC. Wu CYC, et al. Among authors: neumann jt. J Vis Exp. 2018 Jan 5;(131):56694. doi: 10.3791/56694. J Vis Exp. 2018. PMID: 29364254 Free PMC article.
However, the Morris water maze is more stressful than other mazes. The Barnes maze is widely used to measure reference (long-term) memory, while ACA-induced neurocognitive deficits are more closely related to working (short-term) memory. CONCLUSIONS: We have develop …
However, the Morris water maze is more stressful than other mazes. The Barnes maze is widely used to measure reference (long-term) me …
Cardiovascular Biomarkers in Hypertensive Patients with Medical Treatment-Results from the Randomized TEAMSTA Protect I Trial.
Jagodzinski A, Neumann JT, Ojeda F, Sörensen NA, Wild P, Münzel T, Zeller T, Westermann D, Blankenberg S. Jagodzinski A, et al. Among authors: neumann jt. Clin Chem. 2017 Dec;63(12):1877-1885. doi: 10.1373/clinchem.2017.275289. Epub 2017 Sep 13. Clin Chem. 2017. PMID: 28904053 Clinical Trial.
BACKGROUND: High blood pressure (BP) is associated with an increased rate of cardiovascular events and mortality. Cardiovascular biomarkers are able to predict long-term risk in the general population, particularly in diseased cohorts. ...
BACKGROUND: High blood pressure (BP) is associated with an increased rate of cardiovascular events and mortality. Cardiovascular biomarkers …
Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
Zeller T, Schurmann C, Schramm K, Müller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T, Schnabel RB, Roden M, Wahl S, Rotter JI, Ojeda F, Carstensen-Kirberg M, Tregouet DA, Dörr M, Meitinger T, Lackner KJ, Wolf P, Felix SB, Landmesser U, Costanzo S, Ziegler A, Liu Y, Völker U, Palmas W, Prokisch H, Guo X, Herder C, Blankenberg S, Homuth G. Zeller T, et al. Among authors: neumann jt. Hypertension. 2017 Oct;70(4):743-750. doi: 10.1161/HYPERTENSIONAHA.117.09458. Epub 2017 Aug 7. Hypertension. 2017. PMID: 28784648 Free PMC article.
Replication was performed in 2 independent studies of whole-blood transcriptome data including 1990 individuals. For identified candidate genes, a direct link between long-term changes in BP and gene expression over time and by treatment with BP-lowering therapy was assess …
Replication was performed in 2 independent studies of whole-blood transcriptome data including 1990 individuals. For identified candidate ge …
11 results