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Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.
Herbeck JT, Gottlieb GS, Winkler CA, Nelson GW, An P, Maust BS, Wong KG, Troyer JL, Goedert JJ, Kessing BD, Detels R, Wolinsky SM, Martinson J, Buchbinder S, Kirk GD, Jacobson LP, Margolick JB, Kaslow RA, O'Brien SJ, Mullins JI. Herbeck JT, et al. Among authors: nelson gw. J Infect Dis. 2010 Feb 15;201(4):618-26. doi: 10.1086/649842. J Infect Dis. 2010. PMID: 20064070 Free PMC article.
METHODS: The discovery stage comprised 156 individuals from the Multicenter AIDS Cohort Study, enriched with rapid and long-term nonprogressors to increase statistical power. This was followed by replication tests of putatively associated genotypes in an independent popula …
METHODS: The discovery stage comprised 156 individuals from the Multicenter AIDS Cohort Study, enriched with rapid and long-term nonp …
Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression.
Winkler CA, Hendel H, Carrington M, Smith MW, Nelson GW, O'brien SJ, Phair J, Vlahov D, Jacobson LP, Rappaport J, Vasilescu A, Bertin-Maghit S, An P, Lu W, Andrieu JM, Schächter F, Therwath A, Zagury JF. Winkler CA, et al. Among authors: nelson gw. J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1534-8. doi: 10.1097/01.qai.0000127353.01578.63. J Acquir Immune Defic Syndr. 2004. PMID: 15602133
Follow-up of SP demonstrated that these polymorphisms have little effect after 8 years, because the subset of SP who had progression after study entry had the same genotype distribution as the global population of SP, suggesting that factors other than CCR5 or CCR2 genetic varian …
Follow-up of SP demonstrated that these polymorphisms have little effect after 8 years, because the subset of SP who had progression after s …
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
Carrington M, Nelson GW, Martin MP, Kissner T, Vlahov D, Goedert JJ, Kaslow R, Buchbinder S, Hoots K, O'Brien SJ. Carrington M, et al. Among authors: nelson gw. Science. 1999 Mar 12;283(5408):1748-52. doi: 10.1126/science.283.5408.1748. Science. 1999. PMID: 10073943