Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

24 results

Filters applied: . Clear all
Page 1
Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes.
Ozawa K, Nagao M, Konno A, Iwai Y, Vittani M, Kusk P, Mishima T, Hirai H, Nedergaard M, Hirase H. Ozawa K, et al. Among authors: nedergaard m. Int J Mol Sci. 2023 Sep 2;24(17):13590. doi: 10.3390/ijms241713590. Int J Mol Sci. 2023. PMID: 37686396 Free PMC article.
Together, compelling evidence for astrocytic Gq pathway-induced vasodiameter changes was not observed. Our results support the notion that short-term (<10 s) hyperemia is not mediated by GPCR-induced astrocytic Ca(2+) signaling....
Together, compelling evidence for astrocytic Gq pathway-induced vasodiameter changes was not observed. Our results support the notion that s …
Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.
Agarwal N, Lewis LD, Hirschler L, Rivera LR, Naganawa S, Levendovszky SR, Ringstad G, Klarica M, Wardlaw J, Iadecola C, Hawkes C, Carare RO, Wells J, Bakker ENTP, Kurtcuoglu V, Bilston L, Nedergaard M, Mori Y, Stoodley M, Alperin N, de Leon M, van Osch MJP. Agarwal N, et al. Among authors: nedergaard m. J Magn Reson Imaging. 2024 Feb;59(2):431-449. doi: 10.1002/jmri.28759. Epub 2023 May 4. J Magn Reson Imaging. 2024. PMID: 37141288 Free PMC article. Review.
Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial fluid. ...
Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial flu …
Fluid compartments influence elastography of the aging mouse brain.
Ge GR, Rolland JP, Song W, Nedergaard M, Parker KJ. Ge GR, et al. Among authors: nedergaard m. Phys Med Biol. 2023 Apr 17;68(9):095004. doi: 10.1088/1361-6560/acc922. Phys Med Biol. 2023. PMID: 36996842 Free PMC article.
Rheological models are applied, and the strong effect is captured by specific assignment of changes to the glymphatic compartment of the brain fluid structures along with a correlated change in the parenchymal stiffness.Significance. Short-term and longer-term chang …
Rheological models are applied, and the strong effect is captured by specific assignment of changes to the glymphatic compartment of the bra …
Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice.
Delle C, Cankar N, Digebjerg Holgersson C, Hvorup Knudsen H, Schiøler Nielsen E, Kjaerby C, Mori Y, Nedergaard M, Weikop P. Delle C, et al. Among authors: nedergaard m. Sci Rep. 2023 Mar 13;13(1):4137. doi: 10.1038/s41598-023-30630-y. Sci Rep. 2023. PMID: 36914703 Free PMC article.
The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linked to dementia. We herein examined glymphatic transport in mice with long-term obesity induced by a high-fat diet for 10 months. The obese mice developed hypertension and el …
The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linked to dementia. We herein examined glymp …
Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?
Wostyn P, Mader TH, Gibson CR, Nedergaard M. Wostyn P, et al. Among authors: nedergaard m. Eye Brain. 2022 May 4;14:49-58. doi: 10.2147/EB.S354710. eCollection 2022. Eye Brain. 2022. PMID: 35546965 Free PMC article. Review.
The considerations outlined in the present paper further stress the crucial need to develop effective long-term countermeasures to mitigate SANS-related physiologic changes during long-duration spaceflight....
The considerations outlined in the present paper further stress the crucial need to develop effective long-term countermeasures to mi …
Fluid transport in the brain.
Rasmussen MK, Mestre H, Nedergaard M. Rasmussen MK, et al. Among authors: nedergaard m. Physiol Rev. 2022 Apr 1;102(2):1025-1151. doi: 10.1152/physrev.00031.2020. Epub 2021 May 5. Physiol Rev. 2022. PMID: 33949874 Free PMC article. Review.
Consequently, the brain depends on a special fluid [the cerebrospinal fluid (CSF)] that is flushed into brain along the unique perivascular spaces created by astrocytic vascular endfeet. We describe this pathway, coined the term glymphatic system, based on its dependency o …
Consequently, the brain depends on a special fluid [the cerebrospinal fluid (CSF)] that is flushed into brain along the unique perivascular …
Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.
Hauglund NL, Kusk P, Kornum BR, Nedergaard M. Hauglund NL, et al. Among authors: nedergaard m. J Neurosci. 2020 Mar 11;40(11):2371-2380. doi: 10.1523/JNEUROSCI.2223-19.2020. Epub 2020 Feb 11. J Neurosci. 2020. PMID: 32047056 Free PMC article.
Chronic electroencephalography (EEG) is a widely used tool for monitoring cortical electrical activity in experimental animals. Although chronic implants allow for high-quality, long-term recordings in preclinical studies, the electrodes are foreign objects and might there …
Chronic electroencephalography (EEG) is a widely used tool for monitoring cortical electrical activity in experimental animals. Although chr …
Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.
Smith NA, Bekar LK, Nedergaard M. Smith NA, et al. Among authors: nedergaard m. Neurochem Res. 2020 Jan;45(1):100-108. doi: 10.1007/s11064-019-02834-0. Epub 2019 Jun 28. Neurochem Res. 2020. PMID: 31254249 Free PMC article.
Astrocytes are highly dynamic cells that modulate synaptic transmission within a temporal domain of seconds to minutes in physiological contexts such as Long-Term Potentiation (LTP) and Heterosynaptic Depression (HSD). Recent studies have revealed that astrocytes also modu …
Astrocytes are highly dynamic cells that modulate synaptic transmission within a temporal domain of seconds to minutes in physiological cont …
24 results