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Evaluating the stability of colistin and colistin methanesulphonate in human plasma under different conditions of storage.
Dudhani RV, Nation RL, Li J. Dudhani RV, et al. Among authors: nation rl. J Antimicrob Chemother. 2010 Jul;65(7):1412-5. doi: 10.1093/jac/dkq134. Epub 2010 Apr 22. J Antimicrob Chemother. 2010. PMID: 20413406 Free PMC article.
At all three storage temperatures, the stability of CMS was substantially better for the plasma spiked to contain 30 mg/L as compared with 2 mg/L. CONCLUSIONS: The results of our long-term stability study have significant implications for those involved in conducting clini …
At all three storage temperatures, the stability of CMS was substantially better for the plasma spiked to contain 30 mg/L as compared with 2 …
Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus.
Sudhakaran S, Rayner CR, Li J, Kong DC, Gude NM, Nation RL. Sudhakaran S, et al. Among authors: nation rl. Br J Clin Pharmacol. 2008 May;65(5):667-73. doi: 10.1111/j.1365-2125.2007.03067.x. Epub 2007 Dec 17. Br J Clin Pharmacol. 2008. PMID: 18093255 Free PMC article.
AIMS: To investigate the effect of P-gp inhibition on the maternal to foetal transfer of indinavir. METHODS: Term human placentae (n = 12) were from non-HIV infected women. Maternal to foetal transfer of indinavir was examined in the absence and presence of P-gp inhibitors …
AIMS: To investigate the effect of P-gp inhibition on the maternal to foetal transfer of indinavir. METHODS: Term human placentae (n …
High-performance liquid chromatographic method for simple and rapid determination of linezolid in human plasma.
Boak LM, Li J, Nation RL, Rayner CR. Boak LM, et al. Among authors: nation rl. Biomed Chromatogr. 2006 Aug;20(8):782-6. doi: 10.1002/bmc.597. Biomed Chromatogr. 2006. PMID: 16292746
Tests confirmed the stability of linezolid in plasma during three freeze-thaw cycles, on the bench during 24 h and during long-term storage of frozen plasma for up to 12 weeks; in extracts it was stable in the HPLC autosampler over 12 h. ...
Tests confirmed the stability of linezolid in plasma during three freeze-thaw cycles, on the bench during 24 h and during long-term s …
Differential bidirectional transfer of indinavir in the isolated perfused human placenta.
Sudhakaran S, Ghabrial H, Nation RL, Kong DC, Gude NM, Angus PW, Rayner CR. Sudhakaran S, et al. Among authors: nation rl. Antimicrob Agents Chemother. 2005 Mar;49(3):1023-8. doi: 10.1128/AAC.49.3.1023-1028.2005. Antimicrob Agents Chemother. 2005. PMID: 15728898 Free PMC article.
The bidirectional transfer of indinavir was assessed in dually perfused, isolated human placentae. Term placentae (n = 5) were obtained from non-HIV-infected pregnant women. ...
The bidirectional transfer of indinavir was assessed in dually perfused, isolated human placentae. Term placentae (n = 5) were obtain …
Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease.
Evans AM, Faull RJ, Nation RL, Prasad S, Elias T, Reuter SE, Fornasini G. Evans AM, et al. Among authors: nation rl. Kidney Int. 2004 Oct;66(4):1527-34. doi: 10.1111/j.1523-1755.2004.00916.x. Kidney Int. 2004. PMID: 15458447 Free article.
An inverse relationship between dialysis age and muscle L-carnitine concentrations was observed. CONCLUSION: Long-term hemodialysis treatment is associated with a significant reduction in endogenous plasma and muscle L-carnitine levels and a significant increase in plasma …
An inverse relationship between dialysis age and muscle L-carnitine concentrations was observed. CONCLUSION: Long-term hemodialysis t …
Pharmacokinetics of L-carnitine in patients with end-stage renal disease undergoing long-term hemodialysis.
Evans AM, Faull R, Fornasini G, Lemanowicz EF, Longo A, Pace S, Nation RL. Evans AM, et al. Among authors: nation rl. Clin Pharmacol Ther. 2000 Sep;68(3):238-49. doi: 10.1067/mcp.2000.108850. Clin Pharmacol Ther. 2000. PMID: 11014405
Secondary carnitine deficiency may develop in patients with end-stage renal disease undergoing long-term hemodialysis because of dialytic loss. In these patients L-carnitine can be administered to restore plasma and tissue levels. The objective of this study was to evaluat …
Secondary carnitine deficiency may develop in patients with end-stage renal disease undergoing long-term hemodialysis because of dial …
Application of a loading wash-out method for investigating the hepatocellular efflux of a hepatically-generated metabolite, morphine-3-glucuronide.
Evans AM, O'Brien J, Nation RL. Evans AM, et al. Among authors: nation rl. J Pharm Pharmacol. 1999 Nov;51(11):1289-97. doi: 10.1211/0022357991776868. J Pharm Pharmacol. 1999. PMID: 10632087
The mean (+/-s.d.) rate constants for the biliary excretion and sinusoidal efflux of morphine-3-glucuronide were determined to be 0.160 +/- 0.043 and 0.169 +/- 0.068 min(-1), respectively, and the corresponding membrane permeability parameters were 1.12 and 1.18 mL min(-1), respe …
The mean (+/-s.d.) rate constants for the biliary excretion and sinusoidal efflux of morphine-3-glucuronide were determined to be 0.160 +/- …
Plasma concentrations and renal clearance of morphine, morphine-3-glucuronide and morphine-6-glucuronide in cancer patients receiving morphine.
Somogyi AA, Nation RL, Olweny C, Tsirgiotis P, van Crugten J, Milne RW, Cleary JF, Danz C, Bochner F. Somogyi AA, et al. Among authors: nation rl. Clin Pharmacokinet. 1993 May;24(5):413-20. doi: 10.2165/00003088-199324050-00005. Clin Pharmacokinet. 1993. PMID: 8504624
The plasma concentrations and renal clearance values of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were determined in 11 adult cancer patients maintained on a long term oral morphine dosage (10 to 100mg every 4h). Concentrations in plasma and u …
The plasma concentrations and renal clearance values of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were determi …
The disposition and placental transfer of diazepam in cesarean section.
Ridd MJ, Brown KF, Nation RL, Collier CB. Ridd MJ, et al. Among authors: nation rl. Clin Pharmacol Ther. 1989 May;45(5):506-12. doi: 10.1038/clpt.1989.65. Clin Pharmacol Ther. 1989. PMID: 2721106
The disposition parameters and placental transfer of diazepam were determined from blood and both plasma total and free concentration data in five women who had not undergone labor and who received diazepam (5 mg intravenously for 2 minutes) 1 1/2 to 3 hours before cesarean secti …
The disposition parameters and placental transfer of diazepam were determined from blood and both plasma total and free concentration data i …
Diazepam plasma binding in the perinatal period: influence of nonesterified fatty acids.
Ridd MJ, Brown KF, Moore RG, McBride WG, Nation RL. Ridd MJ, et al. Among authors: nation rl. Eur J Clin Pharmacol. 1982;22(2):153-60. doi: 10.1007/BF00542461. Eur J Clin Pharmacol. 1982. PMID: 7094985
The plasma binding of diazepam was determined serially in 24 women undergoing either elective induction of labour (vaginal or emergency caesarean delivery) or elective caesarean section at term and in 5 nonpregnant women requiring abdominal surgery. In the majority of preg …
The plasma binding of diazepam was determined serially in 24 women undergoing either elective induction of labour (vaginal or emergency caes …
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