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Towards a Standardized Classification of the Hepatobiliary Manifestations in Cystic Fibrosis (CFHBI): A Joint ESPGHAN/NASPGHAN Position Paper.
Bodewes FAJA, Freeman AJ, Weymann A, Debray D, Scheers I, Verkade HJ, Narkewicz MR. Bodewes FAJA, et al. Among authors: narkewicz mr. J Pediatr Gastroenterol Nutr. 2024 Jan;78(1):153-165. doi: 10.1097/MPG.0000000000003944. J Pediatr Gastroenterol Nutr. 2024. PMID: 38291686
We recommend using CFHBI (Cystic Fibrosis Hepato-Biliary Involvement) as the updated term to describe and classify all hepatobiliary manifestations in all pwCF. ...
We recommend using CFHBI (Cystic Fibrosis Hepato-Biliary Involvement) as the updated term to describe and classify all hepatobiliary …
Cystic fibrosis liver disease in the post-modulator era.
Narkewicz MR. Narkewicz MR. Curr Opin Pulm Med. 2023 Nov 1;29(6):621-625. doi: 10.1097/MCP.0000000000001017. Epub 2023 Sep 5. Curr Opin Pulm Med. 2023. PMID: 37678151 Review.
The purpose of this review is to assess the current literature on the impact of HEMT on liver disease, progression, regression, and safety. RECENT FINDINGS: Short-term studies of HEMT in pwCF have shown that there is no significant impact on the frequency of liver enzyme a …
The purpose of this review is to assess the current literature on the impact of HEMT on liver disease, progression, regression, and safety. …
Long-term follow-up and liver outcomes in children with cystic fibrosis and nodular liver on ultrasound in a multi-center study.
Leung DH, Ye W, Schwarzenberg SJ, Freeman AJ, Palermo JJ, Weymann A, Alonso EM, Karnsakul WW, Murray KF, Stoll JM, Huang S, Karmazyn B, Masand P, Magee JC, Alazraki AL, Towbin AJ, Nicholas JL, Green N, Otto RK, Siegel MJ, Ling SC, Navarro OM, Harned RK, Narkewicz MR, Molleston JP; CFLD Research Network. Leung DH, et al. Among authors: narkewicz mr. J Cyst Fibros. 2023 Mar;22(2):248-255. doi: 10.1016/j.jcf.2022.07.017. Epub 2022 Aug 16. J Cyst Fibros. 2023. PMID: 35985930
PROMISE: Working with the CF community to understand emerging clinical and research needs for those treated with highly effective CFTR modulator therapy.
Nichols DP, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Kelly A, Narkewicz MR, Pittman JE, Ratjen F, Sagel SD, Rosenfeld M, Schwarzenberg SJ, Singh PK, Solomon GM, Stalvey MS, Kirby S, VanDalfsen JM, Clancy JP, Rowe SM. Nichols DP, et al. Among authors: narkewicz mr. J Cyst Fibros. 2021 Mar;20(2):205-212. doi: 10.1016/j.jcf.2021.02.003. Epub 2021 Feb 19. J Cyst Fibros. 2021. PMID: 33619012 Free PMC article. Review.
Multiple observational research studies are now being conducted to better understand the impacts of this important therapeutic milestone on long-term outcomes, patient care needs, and future research priorities. ...
Multiple observational research studies are now being conducted to better understand the impacts of this important therapeutic milestone on …
Cystic Fibrosis-related Liver Disease: Research Challenges and Future Perspectives.
Debray D, Narkewicz MR, Bodewes FAJA, Colombo C, Housset C, de Jonge HR, Jonker JW, Kelly DA, Ling SC, Poynard T, Sogni P, Trauner M, Witters P, Baumann U, Wilschanski M, Verkade HJ. Debray D, et al. Among authors: narkewicz mr. J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):443-448. doi: 10.1097/MPG.0000000000001676. J Pediatr Gastroenterol Nutr. 2017. PMID: 28753176
A deeper understanding of the pathophysiology and prognostic factors for the long-term evolution of CFLD is fundamental to move forward and has a strong bearing on identifying potential treatments. ...
A deeper understanding of the pathophysiology and prognostic factors for the long-term evolution of CFLD is fundamental to move forwa …
CD4+ and CD8+ T Cell Activation in Children with Hepatitis C.
Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR. Sheiko MA, et al. Among authors: narkewicz mr. J Pediatr. 2016 Mar;170:142-8.e1. doi: 10.1016/j.jpeds.2015.11.055. Epub 2015 Dec 30. J Pediatr. 2016. PMID: 26743497 Free PMC article.
Of note, cytokine production by CD4(+) helper T cells is increased in children with HCV compared with age- and sex-matched control children, which may influence long-term prognosis in children with HCV....
Of note, cytokine production by CD4(+) helper T cells is increased in children with HCV compared with age- and sex-matched control children, …
Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia.
Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN). Shneider BL, et al. Among authors: narkewicz mr. J Pediatr. 2016 Mar;170:211-7.e1-2. doi: 10.1016/j.jpeds.2015.11.058. Epub 2015 Dec 24. J Pediatr. 2016. PMID: 26725209 Free PMC article.
Adverse Events Following Gastrointestinal Endoscopy in Children: Classifications, Characterizations, and Implications.
Kramer RE, Narkewicz MR. Kramer RE, et al. Among authors: narkewicz mr. J Pediatr Gastroenterol Nutr. 2016 Jun;62(6):828-33. doi: 10.1097/MPG.0000000000001038. J Pediatr Gastroenterol Nutr. 2016. PMID: 26594830
BACKGROUND: Previous studies of endoscopic AE in children have focused on intraprocedural and short-term outcomes, such as bleeding, perforation, and infection, and may underestimate the incidence of AEs. ...
BACKGROUND: Previous studies of endoscopic AE in children have focused on intraprocedural and short-term outcomes, such as bleeding, …
Evaluating progression of liver disease from repeat liver biopsies in children with chronic hepatitis C: a retrospective study.
Mohan P, Barton BA, Narkewicz MR, Molleston JP, Gonzalez-Peralta RP, Rosenthal P, Murray KF, Haber B, Schwarz KB, Goodman ZD. Mohan P, et al. Among authors: narkewicz mr. Hepatology. 2013 Nov;58(5):1580-6. doi: 10.1002/hep.26519. Epub 2013 Sep 30. Hepatology. 2013. PMID: 23703847 Free PMC article.
CONCLUSION: Although in aggregate this cohort did not show significant histologic progression of liver disease over 5 years, 29.5% (n = 13) of children showed an increase in severity of fibrosis. These findings may have long-term implications for the timing of follow-up bi …
CONCLUSION: Although in aggregate this cohort did not show significant histologic progression of liver disease over 5 years, 29.5% (n = 13) …
Durability of sustained response shown in paediatric patients with chronic hepatitis C who were treated with interferon alfa-2b plus ribavirin.
Kelly DA, Haber B, González-Peralta RP, Murray KF, Jonas MM, Molleston JP, Narkewicz MR, Sinatra FR, Lang T, Lachaux A, Wirth S, Shelton M, Te HS, Pollack H, Deng W, Noviello S, Albrecht JK. Kelly DA, et al. Among authors: narkewicz mr. J Viral Hepat. 2012 Apr;19(4):263-70. doi: 10.1111/j.1365-2893.2011.01544.x. Epub 2011 Nov 17. J Viral Hepat. 2012. PMID: 22404724
Long-term studies in adults indicate that sustained virologic response (SVR) after combination treatment for chronic hepatitis C (CHC) predicts long-term clearance. ...Similar long-term results could be expected after peginterferon alfa-2b plus ribavirin trea …
Long-term studies in adults indicate that sustained virologic response (SVR) after combination treatment for chronic hepatitis C (CHC …
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