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T3 Intratracheal Therapy Alleviates Pulmonary Pathology in an Elastase-Induced Emphysema-Dominant COPD Mouse Model.
Takahashi N, Nakashima R, Nasu A, Hayashi M, Fujikawa H, Kawakami T, Eto Y, Kishimoto T, Fukuyama A, Ogasawara C, Kawano K, Fujiwara Y, Suico MA, Kai H, Shuto T. Takahashi N, et al. Among authors: nakashima r. Antioxidants (Basel). 2023 Dec 22;13(1):30. doi: 10.3390/antiox13010030. Antioxidants (Basel). 2023. PMID: 38247455 Free PMC article.
T(3)-dependent improvement is likely linked to the up-regulation of Ppargc1a, a master regulator of mitochondrial biogenesis, and Gclm, a factor associated with oxidative stress. Conversely, neither short- nor long-term T(3) treatments improved COPD pathology in the C57BL/ …
T(3)-dependent improvement is likely linked to the up-regulation of Ppargc1a, a master regulator of mitochondrial biogenesis, and Gclm, a fa …
Long-term outcomes of stimulated salivary flow and xerostomia after definitive intensity-modulated radiation therapy for patients with head and neck cancer.
Hiraoka S, Yoshimura M, Nakajima A, Nakashima R, Mizowaki T. Hiraoka S, et al. Among authors: nakashima r. J Radiat Res. 2024 Jan 19;65(1):71-77. doi: 10.1093/jrr/rrad087. J Radiat Res. 2024. PMID: 37996093 Free PMC article.
This retrospective study aimed to evaluate the time to recovery from xerostomia and analyze its predictors, along with long-term outcomes of stimulated salivary flow after intensity-modulated radiation therapy (IMRT) for head and neck cancer (HNC). ...
This retrospective study aimed to evaluate the time to recovery from xerostomia and analyze its predictors, along with long-term outc …
Long-Term Prognosis of Antimelanoma Differentiation-Associated Gene 5-Positive Dermatomyositis With Interstitial Lung Disease.
Sasai T, Nakashima R, Tsuji H, Nakajima T, Imura Y, Yoshida Y, Hirata S, Shirakashi M, Hiwa R, Kitagori K, Akizuki S, Yoshifuji H, Mimori T, Morinobu A. Sasai T, et al. Among authors: nakashima r. J Rheumatol. 2023 Nov;50(11):1454-1461. doi: 10.3899/jrheum.2023-0371. Epub 2023 Sep 15. J Rheumatol. 2023. PMID: 37714541
Previously, we reported the efficacy of a combination therapy comprising high-dose glucocorticoids (GCs), calcineurin inhibitors (CNIs), and intravenous cyclophosphamide (IV CYC) in a multicenter clinical trial (UMIN000014344). In the present study, we evaluated the long-term …
Previously, we reported the efficacy of a combination therapy comprising high-dose glucocorticoids (GCs), calcineurin inhibitors (CNIs), and …
Type 1 diabetes, COVID-19 vaccines and short-term safety: Subgroup analysis from the global COVAD study.
Chatterjee T, Ravichandran N, Nair N, Gracia-Ramos AE, Barman B, Sen P, Joshi M, Saha S, Nune A, Pande AKR, Velikova T, Parodis I, Tan AL, Shinjo SK, Boro H, Agarwal V, Aggarwal R, Gupta L; COVAD Study Group. Chatterjee T, et al. J Diabetes Investig. 2024 Jan;15(1):131-138. doi: 10.1111/jdi.14079. Epub 2023 Sep 11. J Diabetes Investig. 2024. PMID: 37697820 Free PMC article.
This study aimed to evaluate the frequency and severity of short-term (<7-day) adverse vaccination events (AEs) and their risk factors among type 1 diabetes patients. ...
This study aimed to evaluate the frequency and severity of short-term (<7-day) adverse vaccination events (AEs) and their risk fac …
The Safety of Laparoscopic Cholecystectomy in Super-elderly Patients: A Propensity Score Matching Analysis.
Naito S, Kajiwara M, Nakashima R, Sasaki T, Hasegawa S. Naito S, et al. Among authors: nakashima r. Cureus. 2023 Jul 18;15(7):e42097. doi: 10.7759/cureus.42097. eCollection 2023 Jul. Cureus. 2023. PMID: 37602119 Free PMC article.
CONCLUSIONS: There were no clinically significant differences in the short-term outcomes of LC between super-elderly patients aged 85 years and patients aged < 85 years. ...
CONCLUSIONS: There were no clinically significant differences in the short-term outcomes of LC between super-elderly patients aged 85 …
Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study.
Doskaliuk B, Ravichandran N, Sen P, Day J, Joshi M, Nune A, Nikiphorou E, Saha S, Tan AL, Shinjo SK, Ziade N, Velikova T, Milchert M, Jagtap K, Parodis I, Gracia-Ramos AE, Cavagna L, Kuwana M, Knitza J, Chen YM, Makol A, Agarwal V, Patel A, Pauling JD, Wincup C, Barman B, Tehozol EAZ, Serrano JR, La Torre IG, Colunga-Pedraza IJ, Merayo-Chalico J, Chibuzo OC, Katchamart W, Goo PA, Shumnalieva R, Hoff LS, Kibbi LE, Halabi H, Vaidya B, Shaharir SS, Hasan ATMT, Dey D, Gutiérrez CET, Caballero-Uribe CV, Lilleker JB, Salim B, Gheita T, Chatterjee T, Distler O, Saavedra MA; COVAD study group; Chinoy H, Agarwal V, Aggarwal R, Gupta L. Doskaliuk B, et al. Rheumatol Int. 2023 Sep;43(9):1651-1664. doi: 10.1007/s00296-023-05345-y. Epub 2023 Jun 23. Rheumatol Int. 2023. PMID: 37351634 Free PMC article.
Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. ...
Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contrib …
Systemic sclerosis and COVID-19 vaccine safety: short-term insights from the global COVID-19 vaccination in autoimmune disease (COVAD) survey.
Naveen R, Thakare DR, Kuwana M, Pauling JD, Day J, Joshi M, Parodis I, Sen P, Jagtap K, Nikiphorou E, Saha S, Agarwal V, Chatterjee T, Lilleker JB, Kardes S, Milchert M, Gheita T, Salim B, Velikova T, Gracia-Ramos AE, Tan AL, Nune A, Cavagna L, Saavedra MA, Shinjo SK, Ziade N, Knitza J, Distler O, Chinoy H; COVAD Study Group; Aggarwal R, Gupta L, Agarwal V, Makol A. Naveen R, et al. Rheumatol Int. 2023 Jul;43(7):1265-1275. doi: 10.1007/s00296-023-05310-9. Epub 2023 Mar 31. Rheumatol Int. 2023. PMID: 37000295 Free PMC article.
The safety profile of COVID-19 vaccines is understudied in patients with systemic sclerosis (SSc). We compared short-term adverse events (AEs) 7 days following vaccination in patients with SSc vs other rheumatic (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and heal …
The safety profile of COVID-19 vaccines is understudied in patients with systemic sclerosis (SSc). We compared short-term adverse eve …
Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys.
Sen P, R N, Houshmand N, Moghadam Kia S, Joshi M, Saha S, Jagtap K, Agarwal V, Nune A, Nikiphorou E, Tan AL, Shinjo SK, Ziade N, Velikova T, Milchert M, Parodis I, Gracia-Ramos AE, Cavagna L, Kuwana M, Knitza J, Makol A, Patel A, Pauling JD, Wincup C, Barman B, Zamora Tehozol EA, Rojas Serrano J, García-De La Torre I, Colunga-Pedraza IJ, Merayo-Chalico J, Chibuzo OC, Katchamart W, Akawatcharangura Goo P, Shumnalieva R, Chen YM, Hoff LS, El Kibbi L, Halabi H, Vaidya B, Sazliyana Shaharir S, Hasan ATMT, Dey D, Gutiérrez CET, Caballero-Uribe CV, Lilleker JB, Salim B, Gheita T, Chatterjee T, Distler O, Saavedra MA, Day J, Chinoy H; COVAD Study Group; Agarwal V, Aggarwal R, Gupta L. Sen P, et al. Rheumatology (Oxford). 2023 Oct 3;62(10):3291-3301. doi: 10.1093/rheumatology/kead057. Rheumatology (Oxford). 2023. PMID: 36734536 Free article.

Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). ...CONCLUSION: Vaccine hesitancy has decreased from 2021 to

…

Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over

…
Enteric Toll-like receptor 7 stimulation causes acute exacerbation in lupus-susceptible mice.
Takase Y, Shirakashi M, Nishida Y, Katsushima M, Onizawa H, Hiwa R, Tsuji H, Kitagori K, Akizuki S, Onishi A, Nakashima R, Murakami K, Yoshifuji H, Tanaka M, Tsuruyama T, Morinobu A, Hashimoto M. Takase Y, et al. Among authors: nakashima r. Clin Rheumatol. 2023 Apr;42(4):1185-1194. doi: 10.1007/s10067-022-06467-7. Epub 2022 Dec 14. Clin Rheumatol. 2023. PMID: 36515794
However, the mechanism underlying systemic lupus erythematosus (SLE) flares remains unclear. We investigated whether short-term enteric Toll-like receptor 7 (TLR7) stimulation can exacerbate SLE using B6SKG mice, which spontaneously develop SLE due to a mutation in the zet …
However, the mechanism underlying systemic lupus erythematosus (SLE) flares remains unclear. We investigated whether short-term enter …
28 results