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Femoral Occlusion during Neonatal Cardiopulmonary Resuscitation Improves Outcomes in an Ovine Model of Perinatal Cardiac Arrest.
Rawat M, Mani S, Gugino SF, Koenigsknecht C, Helman J, Nielsen L, Nair J, Munshi U, Chandrasekharan P, Lakshminrusimha S. Rawat M, et al. Among authors: nair j. Children (Basel). 2023 Nov 13;10(11):1804. doi: 10.3390/children10111804. Children (Basel). 2023. PMID: 38002895 Free PMC article.
Our objectives were to determine the impact of bilateral femoral occlusion during chest compressions on the incidence and timing of ROSC and hemodynamics. METHODOLOGY: In this randomized study, 19 term fetal lambs in cardiac arrest were resuscitated based on the Neonatal R …
Our objectives were to determine the impact of bilateral femoral occlusion during chest compressions on the incidence and timing of ROSC and …
Polymorphous low-grade neuroepithelial tumour of young (PLNTY): the new kid on the block.
Nair JN, Naidu B, Balasubramanian A, Krishnamurthy G. Nair JN, et al. Childs Nerv Syst. 2024 Feb;40(2):555-561. doi: 10.1007/s00381-023-06162-1. Epub 2023 Oct 5. Childs Nerv Syst. 2024. PMID: 37796295
It is important to recognize and report similar tumors to determine the long-term risk of recurrence and create a more complete understanding on their radiology and molecular genetics....
It is important to recognize and report similar tumors to determine the long-term risk of recurrence and create a more complete under …
GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors.
Nair JD, Wilkinson KA, Yucel BP, Mulle C, Vissel B, Mellor J, Henley JM. Nair JD, et al. iScience. 2023 Aug 25;26(10):107708. doi: 10.1016/j.isci.2023.107708. eCollection 2023 Oct 20. iScience. 2023. PMID: 37720087 Free PMC article.
GluK2(Q) mice also had fewer GluA1-and GluA3-containing AMPA receptors (AMPARs) and reduced postsynaptic AMPAR currents at both MF-CA3 and CA1-Schaffer collateral synapses. Moreover, long-term potentiation of AMPAR-mediated transmission at CA1-Schaffer collateral synapses …
GluK2(Q) mice also had fewer GluA1-and GluA3-containing AMPA receptors (AMPARs) and reduced postsynaptic AMPAR currents at both MF-CA3 and C …
Masked Randomized Trial of Epinephrine versus Vasopressin in an Ovine Model of Perinatal Cardiac Arrest.
Rawat M, Gugino S, Koenigsknecht C, Helman J, Nielsen L, Sankaran D, Nair J, Chandrasekharan P, Lakshminrusimha S. Rawat M, et al. Among authors: nair j. Children (Basel). 2023 Feb 10;10(2):349. doi: 10.3390/children10020349. Children (Basel). 2023. PMID: 36832479 Free PMC article.
Objective: To compare the effect of epinephrine and vasopressin on the incidence and time to return of spontaneous circulation (ROSC), hemodynamics, plasma drug levels, and vasoreactivity in perinatal cardiac arrest. Design/Methods: Twenty-seven term fetal lambs in cardiac …
Objective: To compare the effect of epinephrine and vasopressin on the incidence and time to return of spontaneous circulation (ROSC), hemod …
Understanding Ballistic Injuries.
Ditkofsky N, Nair JR, Frank Y, Mathur S, Nanda B, Moreland R, Rotman JA. Ditkofsky N, et al. Among authors: nair jr. Radiol Clin North Am. 2023 Jan;61(1):119-128. doi: 10.1016/j.rcl.2022.08.005. Epub 2022 Oct 20. Radiol Clin North Am. 2023. PMID: 36336385 Review.
With ballistic injuries, an understanding of how the mechanism of injury translates to the injuries observed makes it possible to make sense of what can, at times be a complex imaging appearance and mitigate against the long-term complications of gunshot wounds. In this ar …
With ballistic injuries, an understanding of how the mechanism of injury translates to the injuries observed makes it possible to make sense …
Alloimmune Neutropenia in a Neonate: Case Report and Review of Literature.
Prasath A, Grafius A, Bonanno M, Ambrusko S, Nair J. Prasath A, et al. Among authors: nair j. Antibodies (Basel). 2022 Oct 3;11(4):63. doi: 10.3390/antib11040063. Antibodies (Basel). 2022. PMID: 36278616 Free PMC article.
Infants affected by this self-limiting condition can present asymptomatically or have a wide range of symptoms, from skin manifestations and mucositis to severe infections such as sepsis and pneumonia. In our case, we report an otherwise asymptomatic term infant born with …
Infants affected by this self-limiting condition can present asymptomatically or have a wide range of symptoms, from skin manifestations and …
Distinct roles of treatment schemes and BRCA2 on the restoration of homologous recombination DNA repair and PARP inhibitor resistance in ovarian cancer.
Huang TT, Burkett SS, Tandon M, Yamamoto TM, Gupta N, Bitler BG, Lee JM, Nair JR. Huang TT, et al. Among authors: nair jr. Oncogene. 2022 Nov;41(46):5020-5031. doi: 10.1038/s41388-022-02491-8. Epub 2022 Oct 12. Oncogene. 2022. PMID: 36224341 Free PMC article.
PARPi-resistant variants PEO1/OlaJR, established by higher initial doses and short-term PARPi treatment, develops PARPi resistance by rapidly restoring functional BRCA2 and promoting drug efflux activity. In contrast, PEO1/OlaR, developed by lower initial doses with long- …
PARPi-resistant variants PEO1/OlaJR, established by higher initial doses and short-term PARPi treatment, develops PARPi resistance by …
Acute intermittent hypercapnic-hypoxia elicits central neural respiratory motor plasticity in humans.
Welch JF, Nair J, Argento PJ, Mitchell GS, Fox EJ. Welch JF, et al. Among authors: nair j. J Physiol. 2022 May;600(10):2515-2533. doi: 10.1113/JP282822. Epub 2022 Apr 28. J Physiol. 2022. PMID: 35348218 Free article.
Acute intermittent hypoxia (AIH) elicits long-term facilitation (LTF) of respiration. Although LTF is observed when CO(2) is elevated during AIH in awake humans, the influence of CO(2) on corticospinal respiratory motor plasticity is unknown. ...Thus, moderate AIHH elicits …
Acute intermittent hypoxia (AIH) elicits long-term facilitation (LTF) of respiration. Although LTF is observed when CO(2) is elevated …
Inadequate Bioavailability of Intramuscular Epinephrine in a Neonatal Asphyxia Model.
Berkelhamer SK, Vali P, Nair J, Gugino S, Helman J, Koenigsknecht C, Nielsen L, Lakshminrusimha S. Berkelhamer SK, et al. Among authors: nair j. Front Pediatr. 2022 Feb 21;10:828130. doi: 10.3389/fped.2022.828130. eCollection 2022. Front Pediatr. 2022. PMID: 35265564 Free PMC article.
Intramuscular (IM) epinephrine may represent a simple, low cost and highly accessible alternative for consideration in the care of infants compromised at birth. At present, the bioavailability of IM epinephrine in asphyxia remains unclear. METHODS: Four term fetal l …
Intramuscular (IM) epinephrine may represent a simple, low cost and highly accessible alternative for consideration in the care of infants c …
Gestational Age Alters Assessment of Neonatal Abstinence Syndrome.
Amiri S, Nair J. Amiri S, et al. Among authors: nair j. Pediatr Rep. 2022 Jan 28;14(1):50-57. doi: 10.3390/pediatric14010009. Pediatr Rep. 2022. PMID: 35225878 Free PMC article.
Neonatal abstinence syndrome (NAS) due to maternal opioid use affects both term and preterm infants; however, the relationship between gestational age and clinical symptomatology is still poorly understood. ...In total, 166 infants with a diagnosis of NAS were included, wi …
Neonatal abstinence syndrome (NAS) due to maternal opioid use affects both term and preterm infants; however, the relationship betwee …
49 results