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Identifying novel therapeutic agents using xenograft models of pediatric cancer.
Kurmasheva RT, Houghton PJ. Kurmasheva RT, et al. Cancer Chemother Pharmacol. 2016 Aug;78(2):221-32. doi: 10.1007/s00280-016-3042-6. Epub 2016 May 18. Cancer Chemother Pharmacol. 2016. PMID: 27193096 Free PMC article. Review.
However, current approaches to curative therapy result in significant morbidity and long-term sequelae, including cardiac dysfunction and cognitive impairment. ...
However, current approaches to curative therapy result in significant morbidity and long-term sequelae, including cardiac dysfunction …
Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma.
Studebaker A, Bondra K, Seum S, Shen C, Phelps DA, Chronowski C, Leasure J, Smith PD, Kurmasheva RT, Mo X, Fouladi M, Houghton PJ. Studebaker A, et al. Pediatr Blood Cancer. 2015 Oct;62(10):1768-74. doi: 10.1002/pbc.25579. Epub 2015 May 15. Pediatr Blood Cancer. 2015. PMID: 25981859 Free PMC article.
Patients with recurrent low-grade tumors or anaplastic astrocytoma may receive radiation treatment; however, the long-term sequellae from radiation treatment can be severe. As many childhood gliomas are associated with activation of BRAF, we have explored the combination o …
Patients with recurrent low-grade tumors or anaplastic astrocytoma may receive radiation treatment; however, the long-term sequellae …