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Dosing implications of rapid elimination of trimethoprim-sulfamethoxazole in patients with cystic fibrosis.
Reed MD, Stern RC, Bertino JS Jr, Myers CM, Yamashita TS, Blumer JL. Reed MD, et al. Among authors: myers cm. J Pediatr. 1984 Feb;104(2):303-7. doi: 10.1016/s0022-3476(84)81019-7. J Pediatr. 1984. PMID: 6607329
The area under the SMZ serum concentration-time curve was significantly greater at steady state, suggesting drug accumulation during long-term therapy. When pharmacokinetic characteristics for TMP and SMZ obtained in patients with cystic fibrosis were compared with those r …
The area under the SMZ serum concentration-time curve was significantly greater at steady state, suggesting drug accumulation during long- …