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Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression.
Mwangi SM, Peng S, Nezami BG, Thorn N, Farris AB 3rd, Jain S, Laroui H, Merlin D, Anania F, Srinivasan S. Mwangi SM, et al. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2):G103-16. doi: 10.1152/ajpgi.00196.2015. Epub 2015 Nov 12. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 26564715 Free PMC article.
They also had significantly reduced peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and CD36 gene expression and protein levels, and lower expression of mRNA coding for enzymes involved in de novo lipogenesis. GDNF-loaded nanoparticles were protective against short- …
They also had significantly reduced peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and CD36 gene expression and protein level …