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Year Number of Results
2013 1
2017 1
2018 2
2019 6
2020 2
2021 3
2023 2
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15 results

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Page 1
The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis.
Muscedere J, Waters B, Varambally A, Bagshaw SM, Boyd JG, Maslove D, Sibley S, Rockwood K. Muscedere J, et al. Intensive Care Med. 2017 Aug;43(8):1105-1122. doi: 10.1007/s00134-017-4867-0. Epub 2017 Jul 4. Intensive Care Med. 2017. PMID: 28676896 Free PMC article. Review.
Two reviewers independently applied eligibility criteria, assessed quality, and extracted data. The primary outcomes were hospital and long-term mortality. We also determined the prevalence of frailty, the impact on other patient-centered outcomes such as discharge disposi …
Two reviewers independently applied eligibility criteria, assessed quality, and extracted data. The primary outcomes were hospital and long- …
Development and validation of a hospital frailty risk measure using Canadian clinical administrative data.
Amuah JE, Molodianovitsh K, Carbone S, Diestelkamp N, Guo Y, Hogan DB, Li M, Maxwell CJ, Muscedere J, Rockwood K, Sinha S, Theou O, Karmakar-Hore S. Amuah JE, et al. Among authors: muscedere j. CMAJ. 2023 Mar 27;195(12):E437-E448. doi: 10.1503/cmaj.220926. CMAJ. 2023. PMID: 36972914 Free PMC article.
For the continuous risk score format (unit = 0.1), the hazard ratio (HR) for 1-year risk of death was 1.39 (95% confidence interval [CI] 1.38-1.41), with a C-statistic of 0.717 (95% CI 0.715-0.720); the odds ratio for high users of hospital beds was 1.85 (95% CI 1.82-1.88), with …
For the continuous risk score format (unit = 0.1), the hazard ratio (HR) for 1-year risk of death was 1.39 (95% confidence interval [CI] 1.3 …
Frailty and Aging: How the Danish Experience Might Inform Canada.
Muscedere J, Barrie C, Chan K, Cooper B, Critchley K, Kim P, Lorbergs A, Mackenzie I, Martineau C, Noseworthy T, O'Neil M, Resin J, Sinha S, Williams R. Muscedere J, et al. Healthc Q. 2019 Apr;22(1):14-21. doi: 10.12927/hcq.2019.25841. Healthc Q. 2019. PMID: 31244463
Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis.
Daneman N, Sarwar S, Fowler RA, Cuthbertson BH; SuDDICU Canadian Study Group. Daneman N, et al. Lancet Infect Dis. 2013 Apr;13(4):328-41. doi: 10.1016/S1473-3099(12)70322-5. Epub 2013 Jan 25. Lancet Infect Dis. 2013. PMID: 23352693 Review.
INTERPRETATION: We detected no relation between the use of SDD or SOD and the development of antimicrobial-resistance in pathogens in patients in the ICU, suggesting that the perceived risk of long-term harm related to selective decontamination cannot be justified by avail …
INTERPRETATION: We detected no relation between the use of SDD or SOD and the development of antimicrobial-resistance in pathogens in patien …
Neurological Impairment in Critically Ill Patients on Dialysis: Research Letter for the INCOGNITO-AKI Feasibility Study.
Jawa NA, Silver SA, Holden RM, Scott SH, Day AG, Norman PA, Kwan BYM, Maslove DM, Muscedere J, Boyd JG. Jawa NA, et al. Among authors: muscedere j. Can J Kidney Health Dis. 2023 Aug 24;10:20543581231192743. doi: 10.1177/20543581231192743. eCollection 2023. Can J Kidney Health Dis. 2023. PMID: 37644980 Free PMC article.
OBJECTIVE: To assess the feasibility of testing the association between intradialytic rSO(2) and acute and long-term neurological outcomes. DESIGN: Longitudinal observational study. ...We measured acute neurological impairment by daily delirium screening and long-term
OBJECTIVE: To assess the feasibility of testing the association between intradialytic rSO(2) and acute and long-term neurological out …
Delirium, Cerebral Perfusion, and High-Frequency Vital-Sign Monitoring in the Critically Ill. The CONFOCAL-2 Feasibility Study.
Khan JM, Wood MD, Lee KFH, Maslove D, Muscedere J, English SW, Ball I, Slessarev M, Boyd JG. Khan JM, et al. Among authors: muscedere j. Ann Am Thorac Soc. 2021 Jan;18(1):112-121. doi: 10.1513/AnnalsATS.202002-093OC. Ann Am Thorac Soc. 2021. PMID: 32780600
The full study will aim to assess the association between noninvasively derived surrogate markers of cerebral perfusion, delirium development, and long-term cognitive outcomes in critically ill patients.Methods: Adult patients in the ICU were enrolled if they had shock and …
The full study will aim to assess the association between noninvasively derived surrogate markers of cerebral perfusion, delirium developmen …
Frailty and associated outcomes and resource utilization following in-hospital cardiac arrest.
Fernando SM, McIsaac DI, Rochwerg B, Cook DJ, Bagshaw SM, Muscedere J, Munshi L, Nolan JP, Perry JJ, Downar J, Dave C, Reardon PM, Tanuseputro P, Kyeremanteng K. Fernando SM, et al. Among authors: muscedere j. Resuscitation. 2020 Jan 1;146:138-144. doi: 10.1016/j.resuscitation.2019.11.011. Epub 2019 Nov 27. Resuscitation. 2020. PMID: 31785373
Secondary outcomes include return of spontaneous circulation (ROSC), discharge to long-term care, and hospital costs. We used multivariable logistic regression to adjust for known confounders. ...CONCLUSIONS: Frail individuals who experience an IHCA are more likely to die …
Secondary outcomes include return of spontaneous circulation (ROSC), discharge to long-term care, and hospital costs. We used multiva …
Association between supportive interventions and healthcare utilization and outcomes in patients on long-term prescribed opioid therapy presenting to acute healthcare settings: a systematic review and meta-analysis.
Deschamps J, Gilbertson J, Straube S, Dong K, MacMaster FP, Korownyk C, Montgomery L, Mahaffey R, Downar J, Clarke H, Muscedere J, Rittenbach K, Featherstone R, Sebastianski M, Vandermeer B, Lynam D, Magnussen R, Bagshaw SM, Rewa OG. Deschamps J, et al. Among authors: muscedere j. BMC Emerg Med. 2021 Jan 29;21(1):17. doi: 10.1186/s12873-020-00398-9. BMC Emerg Med. 2021. PMID: 33514325 Free PMC article.
BACKGROUND: Long-term prescription of opioids by healthcare professionals has been linked to poor individual patient outcomes and high resource utilization. ...CONCLUSION: For patients presenting to acute healthcare settings with complications related to long-term o …
BACKGROUND: Long-term prescription of opioids by healthcare professionals has been linked to poor individual patient outcomes and hig …
Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy.
Fernando SM, McIsaac DI, Rochwerg B, Bagshaw SM, Muscedere J, Munshi L, Ferguson ND, Seely AJE, Cook DJ, Dave C, Tanuseputro P, Kyeremanteng K. Fernando SM, et al. Among authors: muscedere j. Intensive Care Med. 2019 Dec;45(12):1742-1752. doi: 10.1007/s00134-019-05795-8. Epub 2019 Oct 8. Intensive Care Med. 2019. PMID: 31595352
The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of first liberation attempt, and tracheostomy. ...CONCLUSIONS: The presence of frailty among patients receiving mechanical ventilation is associa …
The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of fi …
Association between harm reduction strategies and healthcare utilization in patients on long-term prescribed opioid therapy presenting to acute healthcare settings: a protocol for a systematic review and meta-analysis.
Deschamps J, Gilbertson J, Straube S, Dong K, MacMaster FP, Korownyk C, Montgomery L, Mahaffey R, Downar J, Clarke H, Muscedere J, Rittenbach K, Featherstone R, Sebastianski M, Vandermeer B, Lynam D, Magnussen R, Bagshaw SM, Rewa OG. Deschamps J, et al. Among authors: muscedere j. Syst Rev. 2019 Apr 5;8(1):88. doi: 10.1186/s13643-019-0997-5. Syst Rev. 2019. PMID: 30953550 Free PMC article.
DISCUSSION: This study will better characterize harm reduction strategies for patients on long-term prescribed opioids presenting to acute healthcare settings. It will also add new knowledge and generate greater understanding of key knowledge gaps of the long-term p …
DISCUSSION: This study will better characterize harm reduction strategies for patients on long-term prescribed opioids presenting to …
15 results