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Spp24 derivatives stimulate a Gi-protein coupled receptor-Erk1/2 signaling pathway and modulate gene expressions in W-20-17 cells.
Zhao KW, Murray EJ, Murray SS. Zhao KW, et al. Among authors: murray ss. J Cell Biochem. 2015 May;116(5):767-77. doi: 10.1002/jcb.25032. J Cell Biochem. 2015. PMID: 25501958
Spp24 had no effect on Erk1/2 phosphorylation, but Spp18 stimulated short-term Erk1/2, MEK 1/2, and p38 phosphorylation. Pertussis toxin and a MEK1/2 inhibitor ablated Spp18-stimulated Erk 1/2 phosphorylation, indicating a role for Gi proteins and MEK1/2 in the Spp18-stimu …
Spp24 had no effect on Erk1/2 phosphorylation, but Spp18 stimulated short-term Erk1/2, MEK 1/2, and p38 phosphorylation. Pertussis to …
Late adherent human bone marrow stromal cells form bone and restore the hematopoietic microenvironment in vivo.
Vianna VF, Bonfim DC, Cavalcanti Ados S, Fernandes MC, Kahn SA, Casado PL, Lima IC, Murray SS, Murray EJ, Duarte ME. Vianna VF, et al. Among authors: murray ss. Biomed Res Int. 2013;2013:790842. doi: 10.1155/2013/790842. Epub 2013 Apr 24. Biomed Res Int. 2013. PMID: 23710460 Free PMC article.
Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly diff …
Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite …
Long-term influence of normal variation in neonatal characteristics on human brain development.
Walhovd KB, Fjell AM, Brown TT, Kuperman JM, Chung Y, Hagler DJ Jr, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst TM, Frazier J, Gruen JR, Kaufmann WE, Murray SS, van Zijl P, Mostofsky S, Dale AM; Pediatric Imaging, Neurocognition, and Genetics Study. Walhovd KB, et al. Among authors: murray ss. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20089-94. doi: 10.1073/pnas.1208180109. Epub 2012 Nov 19. Proc Natl Acad Sci U S A. 2012. PMID: 23169628 Free PMC article.
Birth weight was found to exert robust positive effects on regional cortical surface area in multiple regions as well as total brain and caudate volumes. These effects were continuous across birth weight ranges and ages and were not confined to subsets of the sample …
Birth weight was found to exert robust positive effects on regional cortical surface area in multiple regions as well as total brain …
Secreted phosphoprotein-24 kDa (Spp24) attenuates BMP-2-stimulated Smad 1/5 phosphorylation and alkaline phosphatase induction and was purified in a protective complex with alpha2 -Macroglobulins From Serum.
Zhao KW, Murray SS, Murray EJ. Zhao KW, et al. Among authors: murray ss. J Cell Biochem. 2013 Feb;114(2):378-87. doi: 10.1002/jcb.24376. J Cell Biochem. 2013. PMID: 22949401
When Spp24 was administered to W-20-17 mesenchymal stem cells with rhBMP-2, short-term Smad1/5 phosphorylation was inhibited, intermediate-term alkaline phosphatase (ALP) induction was blunted, and long-term mineralization was unaffected. ...
When Spp24 was administered to W-20-17 mesenchymal stem cells with rhBMP-2, short-term Smad1/5 phosphorylation was inhibited, interme …
E64d, a membrane-permeable cysteine protease inhibitor, attenuates the effects of parathyroid hormone on osteoblasts in vitro.
Murray EJ, Grisanti MS, Bentley GV, Murray SS. Murray EJ, et al. Among authors: murray ss. Metabolism. 1997 Sep;46(9):1090-4. doi: 10.1016/s0026-0495(97)90284-5. Metabolism. 1997. PMID: 9284902
A brief preincubation with the membrane-permeable, irreversible cysteine protease inhibitor E64d (10 micrograms/mL) before short-term PTH treatment blunted PTH-induced cell proliferation in subconfluent cultures and also attenuated proliferation and inhibited differentiati …
A brief preincubation with the membrane-permeable, irreversible cysteine protease inhibitor E64d (10 micrograms/mL) before short-term …
The calpain-calpastatin system and cellular proliferation and differentiation in rodent osteoblastic cells.
Murray SS, Grisanti MS, Bentley GV, Kahn AJ, Urist MR, Murray EJ. Murray SS, et al. Exp Cell Res. 1997 Jun 15;233(2):297-309. doi: 10.1006/excr.1997.3550. Exp Cell Res. 1997. PMID: 9194492
In these studies, rat pluripotent mesodermal cells (ROB-C26) and mouse MC3T3-E1 preosteoblasts were induced to differentiate into osteoblasts by long-term culture or in response to bone morphogenetic protein (BMP). ...Calpain II activity increased during differentiation of …
In these studies, rat pluripotent mesodermal cells (ROB-C26) and mouse MC3T3-E1 preosteoblasts were induced to differentiate into osteoblast …
Parathyroid hormone-induced retraction of MC3T3-E1 osteoblastic cells is attenuated by the calpain inhibitor N-Ac-Leu-Leu-norleucinal.
Murray EJ, Tram KK, Murray SS, Lee DB. Murray EJ, et al. Among authors: murray ss. Metabolism. 1995 Feb;44(2):141-4. doi: 10.1016/0026-0495(95)90254-6. Metabolism. 1995. PMID: 7869906
ALLN inhibited PTH-induced retraction for 30 minutes in cells cultured on polystyrene cultureware or gelatin-coated glass cover slips, supporting the hypothesis that PTH-induced activation of the calpains contributes to short-term changes in MC3T3-E1 cell shape. Inhibition …
ALLN inhibited PTH-induced retraction for 30 minutes in cells cultured on polystyrene cultureware or gelatin-coated glass cover slips, suppo …
Identification of calcium-activated neutral protease activity and regulation by parathyroid hormone in mouse osteoblastic cells.
Tram KK, Spencer MJ, Murray SS, Lee DB, Tidball JG, Murray EJ. Tram KK, et al. Among authors: murray ss. Biochem Mol Biol Int. 1993 Apr;29(5):981-7. Biochem Mol Biol Int. 1993. PMID: 8508148
These results, combined with the observation that preincubation with a membrane-permeable cysteine protease inhibitor ablates 50% of the PTH-induced osteoblastic retraction, suggest that calpain-catalyzed hydrolysis of regulatory enzymes or structural proteins plays a role in med …
These results, combined with the observation that preincubation with a membrane-permeable cysteine protease inhibitor ablates 50% of the PTH …