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The magnitude and variability of neurocognitive performance in first-episode psychosis: a systematic review and meta-analysis of longitudinal studies.
Catalan A, McCutcheon RA, Aymerich C, Pedruzo B, Radua J, Rodríguez V, Salazar de Pablo G, Pacho M, Pérez JL, Solmi M, McGuire P, Giuliano AJ, Stone WS, Murray RM, Gonzalez-Torres MA, Fusar-Poli P. Catalan A, et al. Among authors: murray rm. Transl Psychiatry. 2024 Jan 8;14(1):15. doi: 10.1038/s41398-023-02718-6. Transl Psychiatry. 2024. PMID: 38191534 Free PMC article.
This suggests that subgroups of individuals suffer severe disease-related cognitive impairments, whereas others may be much less affected. While these impairments seem stable in the medium term, certain indicators may suggest potential further decline in the long term …
This suggests that subgroups of individuals suffer severe disease-related cognitive impairments, whereas others may be much less affected. W …
Impact of non-medical cannabis legalization with market restrictions on health service use and incident cases of psychotic disorder in Ontario, Canada.
Anderson KK, Rodrigues R, Le B, Mamun M, Archie S, Edwards J, Elton-Marshall T, Gilliland J, Myran DT, Palaniyappan L, Perlman CM, Seabrook JA, Murray RM, Shariff SZ. Anderson KK, et al. Among authors: murray rm. Int J Drug Policy. 2024 Jan;123:104285. doi: 10.1016/j.drugpo.2023.104285. Epub 2023 Dec 10. Int J Drug Policy. 2024. PMID: 38071933
RESULTS: We did not find evidence of increases in health service use or incident cases of psychotic disorders over the short-term (17 month) period following cannabis legalization. However, we found clear increasing trends in health service use and incident cases of substa …
RESULTS: We did not find evidence of increases in health service use or incident cases of psychotic disorders over the short-term (17 …
Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies.
Worker A, Berthert P, Lawrence AJ, Kia SM, Arango C, Dinga R, Galderisi S, Glenthøj B, Kahn RS, Leslie A, Murray RM, Pariante CM, Pantelis C, Weiser M, Winter-van Rossum I, McGuire P, Dazzan P, Marquand AF. Worker A, et al. Among authors: murray rm. Transl Psychiatry. 2023 Dec 2;13(1):373. doi: 10.1038/s41398-023-02661-6. Transl Psychiatry. 2023. PMID: 38042835 Free PMC article.
There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. ...Finally, linear mixed-effects modelling showed that negative deviations in cortical thickness in parietal and temporal regions at b …
There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psych …
Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study.
Pignon B, Peyre H, Ayrolles A, Kirkbride JB, Jamain S, Ferchiou A, Richard JR, Baudin G, Tosato S, Jongsma H, de Haan L, Tarricone I, Bernardo M, Velthorst E, Braca M, Arango C, Arrojo M, Bobes J, Del-Ben CM, Di Forti M, Gayer-Anderson C, Jones PB, La Cascia C, Lasalvia A, Menezes PR, Quattrone D, Sanjuán J, Selten JP, Tortelli A, Llorca PM, van Os J, Rutten BPF, Murray RM, Morgan C, Leboyer M, Szöke A, Schürhoff F. Pignon B, et al. Among authors: murray rm. Epidemiol Psychiatr Sci. 2022 Sep 27;31:e68. doi: 10.1017/S2045796022000464. Epidemiol Psychiatr Sci. 2022. PMID: 36165168 Free PMC article.
For each dimension, the interactions between genes and environment were assessed using linear models and comparing explained variances of 'Genetic' models (solely fitted with PRS-SZ), 'Environmental' models (solely fitted with each environmental stressor), 'Independent' models (w …
For each dimension, the interactions between genes and environment were assessed using linear models and comparing explained variances of 'G …
Schizophrenia: A developmental disorder with a risk of non-specific but avoidable decline.
Murray RM, Bora E, Modinos G, Vernon A. Murray RM, et al. Schizophr Res. 2022 May;243:181-186. doi: 10.1016/j.schres.2022.03.005. Epub 2022 Apr 4. Schizophr Res. 2022. PMID: 35390609
However, poor care can allow a cycle of deterioration to be established, stress increasing dopamine dysregulation, leading to more stress consequent on continuing psychotic experiences, and so further dopamine release. Additionally, long-term antipsychotics can induce dopa …
However, poor care can allow a cycle of deterioration to be established, stress increasing dopamine dysregulation, leading to more stress co …
Guiding Ethical Principles in Engineering Biology Research.
Mackelprang R, Aurand ER, Bovenberg RAL, Brink KR, Charo RA, Delborne JA, Diggans J, Ellington AD, Fortman JLC, Isaacs FJ, Medford JI, Murray RM, Noireaux V, Palmer MJ, Zoloth L, Friedman DC. Mackelprang R, et al. Among authors: murray rm. ACS Synth Biol. 2021 May 21;10(5):907-910. doi: 10.1021/acssynbio.1c00129. Epub 2021 May 12. ACS Synth Biol. 2021. PMID: 33977723
Together, we developed a Statement of Ethics in Engineering Biology Research to guide researchers as they incorporate the consideration of long-term ethical implications of their work into every phase of the research lifecycle. ...
Together, we developed a Statement of Ethics in Engineering Biology Research to guide researchers as they incorporate the consideration of l …
Employment and relationship outcomes in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies.
Ajnakina O, Stubbs B, Francis E, Gaughran F, David AS, Murray RM, Lally J. Ajnakina O, et al. Among authors: murray rm. Schizophr Res. 2021 May;231:122-133. doi: 10.1016/j.schres.2021.03.013. Epub 2021 Apr 8. Schizophr Res. 2021. PMID: 33839370
As employment and relationship status are important long-term outcomes in individuals with a diagnosis of first episode psychosis (FEP) disorders, there is a need to elucidate more accurately the extent of these social deficits in people with FEP. ...
As employment and relationship status are important long-term outcomes in individuals with a diagnosis of first episode psychosis (FE …
Rethinking the course of psychotic disorders: modelling long-term symptom trajectories.
Morgan C, Dazzan P, Lappin J, Heslin M, Donoghue K, Fearon P, Jones PB, Murray RM, Doody GA, Reininghaus U. Morgan C, et al. Among authors: murray rm. Psychol Med. 2022 Oct;52(13):2641-2650. doi: 10.1017/S0033291720004705. Epub 2021 Feb 4. Psychol Med. 2022. PMID: 33536092 Free PMC article.
This may confound efforts to elucidate the predictors of long-term course and related biomarkers....
This may confound efforts to elucidate the predictors of long-term course and related biomarkers....
Cannabis points to the synaptic pathology of mental disorders: how aberrant synaptic components disrupt the highest psychological functions
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Morrison PD, Murray RM. Morrison PD, et al. Among authors: murray rm. Dialogues Clin Neurosci. 2020 Sep;22(3):251-258. doi: 10.31887/DCNS.2020.22.3/pmorrison. Dialogues Clin Neurosci. 2020. PMID: 33162768 Free PMC article. Review.
Cannabis can elicit an acute psychotic reaction, and its long-term use is a risk factor for schizophrenia. The main active psychoactive ingredient (9)-tetrahydrocannabinol (delta(9)-THC) activates cannabinoid 1 (CB1) receptors, which are localized to the terminals of gluta …
Cannabis can elicit an acute psychotic reaction, and its long-term use is a risk factor for schizophrenia. The main active psychoacti …
87 results