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Candidates for Balancing Selection in Leishmania donovani Complex Parasites.
Grace CA, Forrester S, Silva VC, Carvalho KSS, Kilford H, Chew YP, James S, Costa DL, Mottram JC, Costa CCHN, Jeffares DC. Grace CA, et al. Among authors: mottram jc. Genome Biol Evol. 2021 Dec 1;13(12):evab265. doi: 10.1093/gbe/evab265. Genome Biol Evol. 2021. PMID: 34865011 Free PMC article.
We find that signals of balancing selection are generally not shared between populations, consistent with transient adaptive events, rather than long-term balancing selection. We then apply multiple diversity metrics to identify candidate genes with robust signatures of ba …
We find that signals of balancing selection are generally not shared between populations, consistent with transient adaptive events, rather …
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification.
Bussotti G, Gouzelou E, Côrtes Boité M, Kherachi I, Harrat Z, Eddaikra N, Mottram JC, Antoniou M, Christodoulou V, Bali A, Guerfali FZ, Laouini D, Mukhtar M, Dumetz F, Dujardin JC, Smirlis D, Lechat P, Pescher P, El Hamouchi A, Lemrani M, Chicharro C, Llanes-Acevedo IP, Botana L, Cruz I, Moreno J, Jeddi F, Aoun K, Bouratbine A, Cupolillo E, Späth GF. Bussotti G, et al. Among authors: mottram jc. mBio. 2018 Nov 6;9(6):e01399-18. doi: 10.1128/mBio.01399-18. mBio. 2018. PMID: 30401775 Free PMC article.
Here, by conducting longitudinal genome analyses of 10 new Leishmania clinical isolates, we uncovered important differences in gene copy number among genetically highly related strains and revealed gain and loss of gene copies as potential drivers of long-term environmenta …
Here, by conducting longitudinal genome analyses of 10 new Leishmania clinical isolates, we uncovered important differences in gene copy num …
Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells.
Goundry A, Romano A, Lima APCA, Mottram JC, Myburgh E. Goundry A, et al. Among authors: mottram jc. FASEB J. 2018 Mar;32(3):1315-1327. doi: 10.1096/fj.201700797R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29097502 Free PMC article.
Here, we assess the dynamics of the inflammatory responses at the lesion site during experimental long-term, low-dose intradermal infection of the ear, employing noninvasive imaging and genetically modified L. major. ...
Here, we assess the dynamics of the inflammatory responses at the lesion site during experimental long-term, low-dose intradermal inf …