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Possible Neuroprotective Effects of l-Carnitine on White-Matter Microstructural Damage and Cognitive Decline in Hemodialysis Patients.
Ueno Y, Saito A, Nakata J, Kamagata K, Taniguchi D, Motoi Y, Io H, Andica C, Shindo A, Shiina K, Miyamoto N, Yamashiro K, Urabe T, Suzuki Y, Aoki S, Hattori N. Ueno Y, et al. Among authors: motoi y. Nutrients. 2021 Apr 14;13(4):1292. doi: 10.3390/nu13041292. Nutrients. 2021. PMID: 33919810 Free PMC article.
Fourteen hemodialysis patients underwent dMRI and laboratory and neuropsychological tests, which were compared across seven patients each in two groups according to duration of l-carnitine treatment: (1) no or short-term l-carnitine treatment (NSTLC), and (2) long-term …
Fourteen hemodialysis patients underwent dMRI and laboratory and neuropsychological tests, which were compared across seven patients each in …
Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer's Disease Brain Extract in Mouse Brains.
Hayashi T, Shimonaka S, Elahi M, Matsumoto SE, Ishiguro K, Takanashi M, Hattori N, Motoi Y. Hayashi T, et al. Among authors: motoi y. J Alzheimers Dis. 2021;79(4):1701-1711. doi: 10.3233/JAD-201002. J Alzheimers Dis. 2021. PMID: 33459716
One reason may be short observational periods because previous studies mostly used mutated-tau transgenic mice and needed to complete the study before these mice developed neurofibrillary tangles. OBJECTIVE: To examine whether long-term incubation of Alzheimer's disease (A …
One reason may be short observational periods because previous studies mostly used mutated-tau transgenic mice and needed to complete the st …
Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study.
Someya Y, Tamura Y, Kaga H, Nojiri S, Shimada K, Daida H, Ishijima M, Kaneko K, Aoki S, Miida T, Hirayama S, Konishi S, Hattori N, Motoi Y, Naito H, Kawamori R, Watada H. Someya Y, et al. Among authors: motoi y. BMJ Open. 2019 Sep 17;9(9):e031584. doi: 10.1136/bmjopen-2019-031584. BMJ Open. 2019. PMID: 31530621 Free PMC article.
A serious social problem in a super-aged society is the rise in the number of elderly people who need long-term care (LTC), which is mainly due to cerebrovascular disease, dementia, age-related frailty, falls and fractures, and joint disease. ...
A serious social problem in a super-aged society is the rise in the number of elderly people who need long-term care (LTC), which is …
Change of Amyloid-beta 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus.
Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H. Akiba C, et al. Among authors: motoi y. J Alzheimers Dis. 2018;63(3):989-1002. doi: 10.3233/JAD-180059. J Alzheimers Dis. 2018. PMID: 29710721 Free PMC article.
CONCLUSIONS: Change in Abeta42 toxic conformer ratio predicts long-term cognitive outcome in iNPH, even in the low-pTau group....
CONCLUSIONS: Change in Abeta42 toxic conformer ratio predicts long-term cognitive outcome in iNPH, even in the low-pTau group....
Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice.
Elahi M, Motoi Y, Matsumoto SE, Hasan Z, Ishiguro K, Hattori N. Elahi M, et al. Among authors: motoi y. Neurosci Lett. 2016 Jan 1;610:207-12. doi: 10.1016/j.neulet.2015.11.010. Epub 2015 Nov 27. Neurosci Lett. 2016. PMID: 26592481
Physical exercise has been identified as a preventive measure for Alzheimer's disease (AD), one of the neuropathological hallmarks of which, neurofibrillary tangles, consist of hyperphosphorylated insoluble tau. Previous studies demonstrated that long-term treadmill exerci …
Physical exercise has been identified as a preventive measure for Alzheimer's disease (AD), one of the neuropathological hallmarks of which, …
Effects of donepezil dose escalation in Parkinson's patients with dementia receiving long-term donepezil treatment: an exploratory study.
Ishikawa K, Motoi Y, Mizuno Y, Kubo S, Hattori N. Ishikawa K, et al. Among authors: motoi y. Psychogeriatrics. 2014 Jun;14(2):93-100. doi: 10.1111/psyg.12045. Epub 2014 Mar 24. Psychogeriatrics. 2014. PMID: 24661498
BACKGROUND: The benefits of escalating the dose of donepezil in patients who are already receiving long-term treatment with it have not been well evaluated. Therefore, an exploratory study to assess the effects of donepezil dose escalation in patients with Parkinson's dise …
BACKGROUND: The benefits of escalating the dose of donepezil in patients who are already receiving long-term treatment with it have n …
Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: implications of autophagy promotion.
Shimada K, Motoi Y, Ishiguro K, Kambe T, Matsumoto SE, Itaya M, Kunichika M, Mori H, Shinohara A, Chiba M, Mizuno Y, Ueno T, Hattori N. Shimada K, et al. Among authors: motoi y. Neurobiol Dis. 2012 Apr;46(1):101-8. doi: 10.1016/j.nbd.2011.12.050. Epub 2012 Jan 10. Neurobiol Dis. 2012. PMID: 22249108
The protein level of p62 was decreased in LiCl-treated mice. These data suggested that oral long-term lithium treatment could attenuate p-tau-induced motor disturbance not only by inhibiting GSK-3 but also by enhancing autophagy in tauopathy model mice....
The protein level of p62 was decreased in LiCl-treated mice. These data suggested that oral long-term lithium treatment could attenua …