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The cerebral haemodynamic response to somatosensory stimulation in preterm newborn lambs is reduced following intrauterine inflammation and dopamine infusion.
Inocencio IM, Tran NT, Wiersma M, Stoecker K, Nakamura S, Moss TJ, Walker DW, Wong FY. Inocencio IM, et al. Among authors: moss tj. Exp Neurol. 2022 Jun;352:114049. doi: 10.1016/j.expneurol.2022.114049. Epub 2022 Mar 17. Exp Neurol. 2022. PMID: 35305987
Intrauterine inflammation, identified clinically as chorioamnionitis, is a major contributor to the neuropathology arising after preterm birth. The impact of chorioamnionitis on the preterm cerebral functional haemodynamic response is unknown. ...METHODS: At 119 days of ge …
Intrauterine inflammation, identified clinically as chorioamnionitis, is a major contributor to the neuropathology arising after preterm …
Intrauterine inflammation exacerbates maladaptive remodeling of the immature myocardium after preterm birth in lambs.
Vrselja A, Pillow JJ, Bensley JG, Ellery SJ, Ahmadi-Noorbakhsh S, Moss TJ, Black MJ. Vrselja A, et al. Among authors: moss tj. Pediatr Res. 2022 Dec;92(6):1555-1565. doi: 10.1038/s41390-022-01955-7. Epub 2022 Mar 11. Pediatr Res. 2022. PMID: 35277596 Free PMC article.
These effects of prematurity on the heart are exacerbated when preterm birth is preceded by exposure to intrauterine inflammation, a common antecedent of preterm birth. Inflammatory injury to the fetal heart coupled with preterm birth consequently alters neon …
These effects of prematurity on the heart are exacerbated when preterm birth is preceded by exposure to intrauterine inflammation, a …
Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep.
Kelly SB, Stojanovska V, Zahra VA, Moxham A, Miller SL, Moss TJM, Hooper SB, Nold MF, Nold-Petry CA, Dean JM, Bennet L, Polglase GR, Gunn AJ, Galinsky R. Kelly SB, et al. Among authors: moss tjm. J Neuroinflammation. 2021 Aug 31;18(1):189. doi: 10.1186/s12974-021-02238-4. J Neuroinflammation. 2021. PMID: 34465372 Free PMC article.
BACKGROUND: Increased systemic and tissue levels of interleukin (IL)-1beta are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antagonist (Ra) administration would attenuate brain in …
BACKGROUND: Increased systemic and tissue levels of interleukin (IL)-1beta are associated with greater risk of impaired neurodevelopment aft …
The effect of human amnion epithelial cells on lung development and inflammation in preterm lambs exposed to antenatal inflammation.
Papagianis PC, Ahmadi-Noorbakhsh S, Lim R, Wallace E, Polglase G, Pillow JJ, Moss TJ. Papagianis PC, et al. Among authors: moss tj. PLoS One. 2021 Jun 25;16(6):e0253456. doi: 10.1371/journal.pone.0253456. eCollection 2021. PLoS One. 2021. PMID: 34170941 Free PMC article.
Lambs were delivered by cesarean section at 128 d gestation (term ~150 d). Lambs received intravenous hAECs (LPS/hAECs: n = 7; 30x106 cells) or equivalent volumes of saline (LPS/Sal, n = 10; or Sal/Sal, n = 9) immediately after birth. Respiratory support was gradual …
Lambs were delivered by cesarean section at 128 d gestation (term ~150 d). Lambs received intravenous hAECs (LPS/hAECs: n = 7; 30x106 …
Brain inflammation and injury at 48 h is not altered by human amnion epithelial cells in ventilated preterm lambs.
Nott F, Jane Pillow J, Dahl M, Kelly SB, Melville J, McDonald C, Nitsos I, Lim R, Wallace EM, Jenkin G, Polglase GR, Moss TJ, Galinsky R. Nott F, et al. Among authors: moss tj. Pediatr Res. 2020 Jul;88(1):27-37. doi: 10.1038/s41390-020-0815-8. Epub 2020 Mar 2. Pediatr Res. 2020. PMID: 32120374
METHODS: Preterm lambs were delivered by cesarean section at 128-130 days' gestation (term is ~147 days) and either ventilated for 48 h or humanely killed at birth. Lambs received 3 mL surfactant (Curosurf) via endotracheal tube prior to delivery (either with or wit …
METHODS: Preterm lambs were delivered by cesarean section at 128-130 days' gestation (term is ~147 days) and either ventilated for 48 …
Maternal allergic asthma during pregnancy alters fetal lung and immune development in sheep: potential mechanisms for programming asthma and allergy.
Wooldridge AL, Clifton VL, Moss TJM, Lu H, Jamali M, Agostino S, Muhlhausler BS, Morrison JL, De Matteo R, Wallace MJ, Bischof RJ, Gatford KL. Wooldridge AL, et al. Among authors: moss tjm. J Physiol. 2019 Aug;597(16):4251-4262. doi: 10.1113/JP277952. Epub 2019 Jul 3. J Physiol. 2019. PMID: 31192454 Free article.
The ewes were subsequently subjected to repeated airway challenges with HDM (allergic group) or saline (control group) throughout gestation. Tissues were collected at 140 1 days gestational age (term, 147 days). The density of type II alveolar epithelial cells (surfactant …
The ewes were subsequently subjected to repeated airway challenges with HDM (allergic group) or saline (control group) throughout gestation. …
Dose-dependent exacerbation of ventilation-induced lung injury by erythropoietin in preterm newborn lambs.
Allison BJ, LaRosa DA, Barton SK, Hooper S, Zahra V, Tolcos M, Chan KYY, Barbuto J, Inocencio IM, Moss TJ, Polglase GR. Allison BJ, et al. Among authors: moss tj. J Appl Physiol (1985). 2019 Jan 1;126(1):44-50. doi: 10.1152/japplphysiol.00800.2018. Epub 2018 Nov 1. J Appl Physiol (1985). 2019. PMID: 30382807 Free article.
Early low-doses of EPO do not exacerbate ventilation-induced lung inflammation and injury and do not provide any short-term respiratory benefit. High doses (3,000 IU/kg) likely exacerbate lung inflammation and injury in ventilated preterm lambs. ...
Early low-doses of EPO do not exacerbate ventilation-induced lung inflammation and injury and do not provide any short-term respirato …
Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs.
Melville JM, McDonald CA, Bischof RJ, Polglase GR, Lim R, Wallace EM, Jenkin G, Moss TJ. Melville JM, et al. Among authors: moss tj. PLoS One. 2017 Mar 27;12(3):e0173572. doi: 10.1371/journal.pone.0173572. eCollection 2017. PLoS One. 2017. PMID: 28346529 Free PMC article.
Ventilation of preterm neonates causes pulmonary inflammation that can contribute to lung injury, propagate systemically and result in long-term disease. Modulation of this initial response may reduce lung injury and its sequelae. ...Immunomodulatory effects of hAECs reduc …
Ventilation of preterm neonates causes pulmonary inflammation that can contribute to lung injury, propagate systemically and result in long- …
Differential short-term regional effects of early high dose erythropoietin on white matter in preterm lambs after mechanical ventilation.
Barton SK, McDougall AR, Melville JM, Moss TJ, Zahra VA, Lim T, Crossley KJ, Polglase GR, Tolcos M. Barton SK, et al. Among authors: moss tj. J Physiol. 2016 Mar 1;594(5):1437-49. doi: 10.1113/JP271376. Epub 2015 Oct 8. J Physiol. 2016. PMID: 26332509 Free PMC article.
Recombinant human EPO had variable regional effects within the WM when administered during injurious ventilation. The adverse short-term outcomes discourage the use of early high dose EPO administration in preterm ventilated babies....
Recombinant human EPO had variable regional effects within the WM when administered during injurious ventilation. The adverse short-term …
Development of an experimental model of maternal allergic asthma during pregnancy.
Clifton VL, Moss TJ, Wooldridge AL, Gatford KL, Liravi B, Kim D, Muhlhausler BS, Morrison JL, Davies A, De Matteo R, Wallace MJ, Bischof RJ. Clifton VL, et al. Among authors: moss tj. J Physiol. 2016 Mar 1;594(5):1311-25. doi: 10.1113/JP270752. Epub 2015 Sep 2. J Physiol. 2016. PMID: 26235954 Free PMC article.
Maternal lung, fetal and placental phenotypes were characterised at 140 1 days gestational age (term, 147 days). The eosinophil influx into lungs was greater after HDM challenge in allergic ewes than after saline challenge in control ewes before mating and in late gestatio …
Maternal lung, fetal and placental phenotypes were characterised at 140 1 days gestational age (term, 147 days). The eosinophil influ …
73 results